Q653S9 · NCPR3_ORYSJ

Function

function

This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes (By similarity) (PubMed:23053415).
It can also provide electron transfer to heme oxygenase and cytochrome B5 (By similarity).

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
FAD (UniProtKB | Rhea| CHEBI:57692 )

Note: Binds 1 FAD per monomer.
FMN (UniProtKB | Rhea| CHEBI:58210 )

Note: Binds 1 FMN per monomer.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site111-116FMN (UniProtKB | ChEBI)
Binding site166-169FMN (UniProtKB | ChEBI)
Binding site204-213FMN (UniProtKB | ChEBI)
Binding site239FMN (UniProtKB | ChEBI)
Binding site331NADP+ (UniProtKB | ChEBI)
Binding site492-495FAD (UniProtKB | ChEBI)
Binding site510-512FAD (UniProtKB | ChEBI)
Binding site526-529FAD (UniProtKB | ChEBI)
Binding site573NADP+ (UniProtKB | ChEBI)
Binding site634-635NADP+ (UniProtKB | ChEBI)
Binding site640-644NADP+ (UniProtKB | ChEBI)
Binding site676NADP+ (UniProtKB | ChEBI)
Binding site714FAD (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentendoplasmic reticulum membrane
Molecular Functionflavin adenine dinucleotide binding
Molecular FunctionFMN binding
Molecular FunctionNADP binding
Molecular FunctionNADPH-hemoprotein reductase activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NADPH--cytochrome P450 reductase 3
  • EC number
  • Short names
    CPR
    ; P450R

Gene names

    • Name
      CPR3
    • ORF names
      OJ1065_E04.12
    • Ordered locus names
      Os09g0558900
      , LOC_Os09g38620

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Nipponbare
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > Liliopsida > Poales > Poaceae > BOP clade > Oryzoideae > Oryzeae > Oryzinae > Oryza > Oryza sativa

Accessions

  • Primary accession
    Q653S9
  • Secondary accessions
    • A0A0P0XRI2

Proteomes

Genome annotation databases

Subcellular Location

Endoplasmic reticulum membrane
; Single-pass membrane protein

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-44Lumenal
Transmembrane45-65Helical
Topological domain66-714Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for chain, modified residue (large scale data).

TypeIDPosition(s)SourceDescription
ChainPRO_00004514301-714UniProtNADPH--cytochrome P450 reductase 3
Modified residue (large scale data)300PTMeXchangePhosphoserine

Proteomic databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region74-103Disordered
Compositional bias86-102Basic and acidic residues
Domain105-255Flavodoxin-like
Domain311-559FAD-binding FR-type

Sequence similarities

Belongs to the NADPH--cytochrome P450 reductase family.
In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
In the N-terminal section; belongs to the flavodoxin family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    714
  • Mass (Da)
    78,802
  • Last updated
    2004-10-25 v1
  • Checksum
    04F5C40ABEA9F8EB
MDSGGGGGGGALRPSALDLVAALLTGRGRPEEEGWPPSLAENRHLIVLLTTSLAVLVGCGVALLVRRSSISAPAVRAQEPQPRAPAPAKRKQEAEPDPDDGRQRVAVFFGTQTGTAEGFAKALAEEAKSRYDKAVFKVLDLDEYAADDEEYEQKLKKEIIALFFVATYGDGEPTDNAARFYKWFGEGNERGEWLSNLRFGVFGLGNRQYEHFNKVGKVVDQLLAEQGGKRIVPLGLGDDDQCIEDDFNAWKELLWPELDKLLRVEDDKSAAPTPYTAAIPEYRVVLVKPEEAMHINKSFSLSNGHAVYDIQHPCRANVAVRRELHTPASYRSCIHLEFDISGTGLTYETGDHVGVYAENCTETVEEVENLLGYSPDTLFSIHADQEDGTPLFGGSLPPPFPSPCTVGTALARYADLLSFPKKSALIALASHASDPKDAERLRHLASPAGKKEYSQWIVSSQRSLLEVMTEFPSAKPPLGVFFAAIAPRLQPRYYSISSSPRMTPTRIHVTCALVYGQTPTGRIHKGVCSTWMKNSIPLEESQECSWAPIFVRQSNFKLPTDPTVPIIMIGPGTGLAPFRGFLQERLALKETGVELGHAVLFFGCRNRKMDFIYEDELNNFVETGALSELIVAFSREGPSKEYVQHKMAEKAPEIWSIISQGGYIYVCGDAKGMARDVHRTLHTIVQEQGSLDNSNTESYVKSLQMEGRYLRDVW

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias86-102Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AP005090
EMBL· GenBank· DDBJ
BAD45947.1
EMBL· GenBank· DDBJ
Genomic DNA
AP008215
EMBL· GenBank· DDBJ
BAF25828.1
EMBL· GenBank· DDBJ
Genomic DNA
AP014965
EMBL· GenBank· DDBJ
BAT09381.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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