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Q64685 · SIAT1_MOUSE

  • Protein
    Beta-galactoside alpha-2,6-sialyltransferase 1
  • Gene
    St6gal1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Transfers sialic acid from CMP-sialic acid to galactose-containing acceptor substrates.

Catalytic activity

Pathway

Protein modification; protein glycosylation.

Features

Showing features for binding site.

140350100150200250300350400
TypeIDPosition(s)Description
Binding site186substrate
Binding site209substrate
Binding site230substrate
Binding site319-321substrate
Binding site350substrate
Binding site351substrate
Binding site362substrate
Binding site366substrate
Binding site367substrate
Binding site373substrate

GO annotations

AspectTerm
Cellular Componentextracellular region
Cellular ComponentGolgi cisterna membrane
Cellular ComponentGolgi medial cisterna
Cellular ComponentGolgi membrane
Cellular ComponentGolgi trans cisterna
Molecular Functionbeta-galactoside alpha-2,6-sialyltransferase activity
Molecular Functionprotein homodimerization activity
Molecular Functionsialyltransferase activity
Biological ProcessN-acetylneuraminate metabolic process
Biological Processnegative regulation of chemotaxis
Biological Processnegative regulation of macrophage apoptotic process
Biological Processpositive regulation of mononuclear cell proliferation
Biological Processprotein glycosylation
Biological Processprotein N-linked glycosylation via asparagine
Biological Processregulation of substrate adhesion-dependent cell spreading
Biological Processresponse to ethanol
Biological Processsialylation

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Beta-galactoside alpha-2,6-sialyltransferase 1
  • EC number
  • Short names
    Alpha 2,6-ST 1
  • Alternative names
    • CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 1
    • ST6Gal I (ST6GalI)
    • Sialyltransferase 1

Gene names

    • Name
      St6gal1
    • Synonyms
      Siat1

Organism names

  • Taxonomic identifier
  • Strains
    • C57BL/6J
    • FVB/N
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q64685
  • Secondary accessions
    • Q8K1L1

Proteomes

Organism-specific databases

Subcellular Location

Golgi apparatus, Golgi stack membrane
; Single-pass type II membrane protein
Note: Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid.

Features

Showing features for topological domain, transmembrane.

Type
IDPosition(s)Description
Topological domain1-9Cytoplasmic
Transmembrane10-26Helical; Signal-anchor for type II membrane protein
Topological domain27-403Lumenal

Keywords

Phenotypes & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis139No effect on enzyme activity.
Mutagenesis181Loss of enzyme activity.
Mutagenesis350Loss of enzyme activity.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 31 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain, disulfide bond, glycosylation, modified residue.

Type
IDPosition(s)Description
ChainPRO_00001492501-403Beta-galactoside alpha-2,6-sialyltransferase 1
Disulfide bond139↔403
Glycosylation146N-linked (GlcNAc...) asparagine
Glycosylation158N-linked (GlcNAc...) asparagine
Disulfide bond181↔332
Disulfide bond350↔361
Modified residue366Phosphotyrosine

Post-translational modification

The soluble form derives from the membrane form by proteolytic processing.
N-glycosylated.

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Monomer and homodimer.

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Sequence similarities

Belongs to the glycosyltransferase 29 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    403
  • Mass (Da)
    46,586
  • Last updated
    2011-07-27 v2
  • MD5 Checksum
    E458CE9AB04EE1AB9615F48BA0895736
MIHTNLKRKFSCFVLVFLLFAIICVWKKGSDYEALTLQAKVFQMPKSQEKVAVGPAPQAVFSNSKQDPKEGVQILSYPRVTAKVKPQPSLQVWDKDSTYSKLNPRLLKIWRNYLNMNKYKVSYKGPGPGVKFSVEALRCHLRDHVNVSMIEATDFPFNTTEWEGYLPKENFRTKAGPWHKCAVVSSAGSLKNSQLGREIDNHDAVLRFNGAPTDNFQQDVGTKTTIRLVNSQLVTTEKRFLKDSLYTEGILILWDPSVYHADIPQWYQKPDYNFFETYKSYRRLHPSQPFYILKPQMPWELWDIIQEISPDLIQPNPPSSGMLGIIIMMTLCDQVDIYEFLPSKRKTDVCYYHQKFFDSACTMGAYHPLLFEKNMVKHLNEGTDEDIYLFGKATLSGFRNNRC

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
D3Z1Z5D3Z1Z5_MOUSESt6gal133

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict131in Ref. 1; BAA03680
Sequence conflict136in Ref. 1; BAA03680
Sequence conflict155in Ref. 1; BAA03680
Sequence conflict170in Ref. 1; BAA03680
Sequence conflict178-179in Ref. 1; BAA03680

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
D16106
EMBL· GenBank· DDBJ
BAA03680.1
EMBL· GenBank· DDBJ
mRNA
AK084124
EMBL· GenBank· DDBJ
BAC39120.1
EMBL· GenBank· DDBJ
mRNA
CH466521
EMBL· GenBank· DDBJ
EDK97666.1
EMBL· GenBank· DDBJ
Genomic DNA
CH466521
EMBL· GenBank· DDBJ
EDK97667.1
EMBL· GenBank· DDBJ
Genomic DNA
BC027833
EMBL· GenBank· DDBJ
AAH27833.1
EMBL· GenBank· DDBJ
mRNA
BC092222
EMBL· GenBank· DDBJ
AAH92222.1
EMBL· GenBank· DDBJ
mRNA
BC096026
EMBL· GenBank· DDBJ
AAH96026.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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