Q64633 · UD17_RAT
- ProteinUDP-glucuronosyltransferase 1A7
- GeneUgt1a7
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids531 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score5/5
Function
function
UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile. Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds. Catalyzes the glucuronidation of endogenous estrogen hormone epiestradiol. Also catalyzes the glucuronidation of the isoflavones genistein, daidzein, glycitein, formononetin, biochanin A and prunetin, which are phytoestrogens with anticancer and cardiovascular properties. Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist caderastan, a drug which can inhibit the effect of angiotensin II. Involved in the biotransformation of 7-ethyl-10-hydroxycamptothecin (SN-38), the pharmacologically active metabolite of the anticancer drug irinotecan.
Catalytic activity
- glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H+ + UDPThis reaction proceeds in the forward direction.
- 17alpha-estradiol + UDP-alpha-D-glucuronate = 17alpha-estradiol 3-O-(beta-D-glucuronate) + H+ + UDPThis reaction proceeds in the forward direction.
- mycophenolate + UDP-alpha-D-glucuronate = H+ + mycophenolate 7-O-beta-D-glucuronide + UDPThis reaction proceeds in the forward direction.
- SN-38 + UDP-alpha-D-glucuronate = H+ + SN-38 O-beta-D-glucuronide + UDPThis reaction proceeds in the forward direction.
- prunetin + UDP-alpha-D-glucuronate = prunetin-5-O-beta-D-glucuronide + UDPThis reaction proceeds in the forward direction.
- candesartan + UDP-alpha-D-glucuronate = candesartan O-beta-D-glucuronoside + UDPThis reaction proceeds in the forward direction.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum | |
Cellular Component | endoplasmic reticulum membrane | |
Molecular Function | enzyme binding | |
Molecular Function | glucuronosyltransferase activity | |
Biological Process | cellular glucuronidation | |
Biological Process | coumarin catabolic process | |
Biological Process | estrogen catabolic process | |
Biological Process | liver development | |
Biological Process | response to organic cyclic compound |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameUDP-glucuronosyltransferase 1A7
- EC number
- Short namesUGT1A7
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionQ64633
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Single-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 487-503 | Helical | ||||
Sequence: LDVIGFLLAIVLTVVFI |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-25 | |||||
Sequence: MAPADVPASLPLGLCLLLASGFGHA | ||||||
Chain | PRO_0000036021 | 26-531 | UDP-glucuronosyltransferase 1A7 | |||
Sequence: GKLLVVPMDGSHWFTMQMVVEKLLPKGHEVVVVVPEVSWQLGKPLNFTVKTYSVSHTQEDLNREFKFFIDSQWKTQQESGVLPLLTSPAQGFFELLFSHCRSLFKDKKLVEYLKQSSFDAVFLDPFDVCGLTVAKYFSLPSVVFSRGIFCHYLEEGSQCPSPPSYVPRPILKLTDTMTFKERVWNLLSYMGEHAFCPSFFKTATDIASEVLQTPVTMTDLFSPVSVWLLRTDFTLELPRPVMPNVIHIGGINCHQRKPVSKEFEAYVNASGEHGIVVFSLGSMVSEIPEKKAMEIAEALGRIPQTLLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKARAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAIVLTVVFIVYKSCAYGCRKCFGGKGRVKKSHKSKTH | ||||||
Glycosylation | 71 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 293 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 431 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Keywords
- PTM
PTM databases
Interaction
Subunit
Homodimer. Homooligomer. Interacts with UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A8, UGT1A9 and UGT1A10 to form heterodimers.
Structure
Family & Domains
Sequence similarities
Belongs to the UDP-glycosyltransferase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
This entry describes 1 isoforms produced by Alternative splicing. UGT1A7 is one of the isoforms produced at the UGT1A complex locus. The UGT1A complex locus produces different isoforms based on alternative use of promoters, first exons and terminal exons.
Q64633-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length531
- Mass (Da)59,627
- Last updated1997-11-01 v1
- ChecksumBC791DCE724CA621
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
D38062 EMBL· GenBank· DDBJ | BAA07258.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
M34007 EMBL· GenBank· DDBJ | AAA42312.1 EMBL· GenBank· DDBJ | mRNA | Different termination. |