Q645N1 · Q645N1_SOLLC
- ProteinMalate dehydrogenase
- GenemMDH
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids346 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score2/5
Function
Catalytic activity
- (S)-malate + NAD+ = H+ + NADH + oxaloacetate
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 40-46 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: GAAGGIG | ||||||
Binding site | 66 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 113 | substrate | ||||
Sequence: R | ||||||
Binding site | 119 | substrate | ||||
Sequence: R | ||||||
Binding site | 126 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 149-151 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: ISN | ||||||
Binding site | 151 | substrate | ||||
Sequence: N | ||||||
Binding site | 185 | substrate | ||||
Sequence: R | ||||||
Active site | 209 | Proton acceptor | ||||
Sequence: H |
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | mitochondrion | |
Molecular Function | L-malate dehydrogenase activity | |
Biological Process | malate metabolic process | |
Biological Process | tricarboxylic acid cycle |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMalate dehydrogenase
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > asterids > lamiids > Solanales > Solanaceae > Solanoideae > Solaneae > Solanum > Solanum subgen. Lycopersicon
Accessions
- Primary accessionQ645N1
Subcellular Location
UniProt Annotation
GO Annotation
Expression
Gene expression databases
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 35-177 | Lactate/malate dehydrogenase N-terminal | ||||
Sequence: KVAVLGAAGGIGQPLSLLMKLNPLVSSLSLYDIAGTPGVAADVSHINTRSEVAGFAGEEQLGQALEGADVVIIPAGVPRKPGMTRDDLFNINAGIVKSLCTAIAKYCPNALVNMISNPVNSTVPIAAEVFKKAGTYDEKKLFG | ||||||
Domain | 179-342 | Lactate/malate dehydrogenase C-terminal | ||||
Sequence: TMLDVVRAKTFYAGKAKVNVAEVNLPVVGGHAGITILPLFSQATPKANLSYEEIVALTKRTQDGGTEVVEAKAGKGSXTLSIAYAGAIFADACLKGLNGVPDVVECAFVQSNVTELPFFASKVRLGKNGVEEVLGLGPLNDYEKQGLEALKPELLSSIEKGIKF |
Sequence similarities
Belongs to the LDH/MDH superfamily. MDH type 1 family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length346
- Mass (Da)36,152
- Last updated2004-10-25 v1
- Checksum7561FC1C51100EC8