PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1387; SER-1509; SER-1511; SER-1513; SER-1537 AND SER-1539, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2 AND LYS-3, CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS], IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
Top2beta controls spinal motor neurons (MN) migration and connectivity; is not required for MN generation or survival; has a selective role in columnar specification. In absence of Top2beta phrenic MN identity is eroded while other motor columns are partially preserved but fail to cluster to their proper position. In Top2beta-/- mice peripheral connectivity is impaired as MNs exhibit a profound deficit in terminal b...
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