Q64380 · SARDH_RAT

  • Protein
    Sarcosine dehydrogenase, mitochondrial
  • Gene
    Sardh
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Catalyzes the last step of the oxidative degradation of choline to glycine. Converts sarcosine into glycine.

Catalytic activity

Cofactor

FAD (UniProtKB | Rhea| CHEBI:57692 )

Note: Binds 1 FAD covalently per monomer.

Pathway

Amine and polyamine degradation; sarcosine degradation; formaldehyde and glycine from sarcosine: step 1/1.

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentmitochondrial matrix
Cellular Componentmitochondrion
Molecular Functionflavin adenine dinucleotide binding
Molecular Functionfolic acid binding
Molecular Functionoxidoreductase activity
Molecular Functionsarcosine dehydrogenase activity
Biological Processcholine catabolic process
Biological Processglycine biosynthetic process
Biological Processsarcosine catabolic process
Biological Processtetrahydrofolate interconversion

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Sarcosine dehydrogenase, mitochondrial
  • EC number
  • Short names
    SarDH

Gene names

    • Name
      Sardh

Organism names

  • Taxonomic identifier
  • Strains
    • Sprague-Dawley
    • Wistar
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    Q64380
  • Secondary accessions
    • O88499

Proteomes

Organism-specific databases

Subcellular Location

PTM/Processing

Features

Showing features for transit peptide, chain, modified residue.

TypeIDPosition(s)Description
Transit peptide1-22Mitochondrion
ChainPRO_000001077223-919Sarcosine dehydrogenase, mitochondrial
Modified residue38N6-succinyllysine
Modified residue109Tele-8alpha-FAD histidine
Modified residue174N6-acetyllysine; alternate
Modified residue174N6-succinyllysine; alternate
Modified residue378N6-succinyllysine
Modified residue392N6-succinyllysine
Modified residue535N6-succinyllysine
Modified residue560N6-acetyllysine
Modified residue776N6-acetyllysine
Modified residue778Phosphotyrosine
Modified residue803N6-acetyllysine; alternate
Modified residue803N6-succinyllysine; alternate
Modified residue885N6-acetyllysine; alternate
Modified residue885N6-succinyllysine; alternate
Modified residue905N6-acetyllysine; alternate
Modified residue905N6-succinyllysine; alternate

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

High levels in liver, lung, kidney, thymus and oviduct, and intermediate levels in the prostate, seminal vesicle, cardiac muscle and neuro-intermediate pituitary lobe. Also expressed in pancreas and adrenal gland.

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the GcvT family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    919
  • Mass (Da)
    101,440
  • Last updated
    2004-08-16 v2
  • Checksum
    E49E54207BD1DBFB
MASLSRVLRVAATCPRGRSARNLGLQPLAREARPTTEKSVPYQCTLKEEAQGASVVPQGPSQPLPSTANVVVIGGGSLGCQTLYHLAKLGVGGVVLLERERLTSGTTWHTAGLLWQLRPSDVEVELLAHTRQVVSHDLEEETGLHTGWIQNGGLFIASNQQRLDEYKRLMSLGKAYGIESHVLSPAETKDLYPLMNVDDLYGTLYVPRDGTMDPAGTCTTLTRAAVARGAQVIENCAVTGIRVRTDDFGVRRVTAVETQHGSIQTPCVVNCAGVWASSVGRMAGVKVPLVAMHHAYVVTERIEGIQNMPNVRDHDASVYLRLQGDALSVGGYEANPIFWDEVSDKFAFGLFDLDWDVFTQHIEGAINRVPVLEKTGIKSTVCGPESFTPDHKPLMGEAPELRGFFLGCGFNSAGMMLGGGCGQELAHWIVHGRPEKDMYSYDIRRFHHSLTDHPRWIRERSHESYAKNYSVVFPHDEPLAGRNMRRDPLHEELLGQGCVFQERQGWERPGWFNPQETAQVLDYDYYGAYGHQAHKDYAYSRLLGDEYTFDFPPHHCVIQKECLACRTAAAVFNMSYFGKFYLLGADARKAPDWLFSADVNRPPGSTVYTCMLNQRGGTESDLTVSCLAPGAQASPLAPAFEGDGYYLAVGGAVAQHNWSHINTVLQDQEFRCQLMDCSEDLGMLSIQGPASRDILQDVLDADLSNEAFPFSTHQLVRAAGHLVRAIRLSFVGELGWELHVPQASCLPVYRAVMAAGAKHGLVNAGYRAIDSLSIEKGYRHWHADLRSDDSPLEAGLAFTCKLKTSVPFLGREALEKQRATGLRRRLVCLTVEEEVPMFGLEAIWRNGQVVGHVRRADFGFTVNKTIAYGYIRDPSGGPVSLDFVKNGDYALERMGVTYAAQVHLKSPFDPDNKRVKGIY

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
F1LRY5F1LRY5_RATSardh919

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict92-102in Ref. 1; AAB03674/AAB04667
Sequence conflict114-115in Ref. 2; AA sequence
Sequence conflict154in Ref. 1; AAB03674/AAB04667

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF067650
EMBL· GenBank· DDBJ
AAD03414.1
EMBL· GenBank· DDBJ
mRNA
U62481
EMBL· GenBank· DDBJ
AAB03674.1
EMBL· GenBank· DDBJ
mRNA
L79910
EMBL· GenBank· DDBJ
AAB04667.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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