Q64378 · FKBP5_MOUSE

  • Protein
    Peptidyl-prolyl cis-trans isomerase FKBP5
  • Gene
    Fkbp5
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Immunophilin protein with PPIase and co-chaperone activities. Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded. Acts as a regulator of Akt/AKT1 activity by promoting the interaction between Akt/AKT1 and PHLPP1, thereby enhancing dephosphorylation and subsequent activation of Akt/AKT1. Interacts with IKBKE and IKBKB which facilitates IKK complex assembly leading to increased IKBKE and IKBKB kinase activity, NF-kappaB activation, and IFN production.

Catalytic activity

Activity regulation

Inhibited by both FK506 and rapamycin.

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentcytosol
Cellular Componentnucleoplasm
Molecular Functionheat shock protein binding
Molecular Functionpeptidyl-prolyl cis-trans isomerase activity
Biological Processchaperone-mediated protein folding
Biological Processresponse to bacterium

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Peptidyl-prolyl cis-trans isomerase FKBP5
  • EC number
  • Short names
    PPIase FKBP5
  • Alternative names
    • 51 kDa FK506-binding protein (51 kDa FKBP; FKBP-51)
    • FK506-binding protein 5 (FKBP-5)
    • Rotamase

Gene names

    • Name
      Fkbp5
    • Synonyms
      Fkbp51

Organism names

  • Taxonomic identifier
  • Strains
    • BALB/cJ
    • FVB/N
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q64378

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Phenotypes & Variants

Variants

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The viewer provides 25 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Chemistry

PTM/Processing

Features

Showing features for modified residue, chain.

TypeIDPosition(s)Description
Modified residue1N-acetylmethionine
ChainPRO_00000753251-456Peptidyl-prolyl cis-trans isomerase FKBP5
Modified residue28N6-acetyllysine
Modified residue155N6-acetyllysine
Modified residue444Phosphoserine

Post-translational modification

Acetylation impairs ability to promote interaction between Akt/AKT1 and PHLPP1. Deacetylation by SIRT7 promotes interaction between Akt/AKT1 and PHLPP1, leading to suppress Akt/AKT1 activation.
Ubiquitinated, leading to degradation in a proteasome-dependent manner. Deubiquitinated by USP49, leading to stabilization.

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Widely expressed, highest levels found in the liver, skeletal muscle, kidney and thymus. Expression is regulated during adipocyte differentiation.

Gene expression databases

Interaction

Subunit

Part of a heteromultimeric cytoplasmic complex with HSP90AA1, HSPA1A/HSPA1B and steroid receptors (PubMed:11751894).
Upon ligand binding dissociates from the complex and FKBP4 takes its place (PubMed:11751894).
Interacts with functionally mature heterooligomeric progesterone receptor complexes along with HSP90 and TEBP (By similarity).
Interacts with NR3C1 (PubMed:21994940).
Interacts with Akt/AKT1 and PHLPP1; enhancing dephosphorylation and subsequent activation of Akt/AKT1 (By similarity).
Interacts with IFI44L; this interaction modulates the kinase activity of IKBKB and IKBKE (By similarity).
Interacts with IKBKB and IKBKE (By similarity).

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q64378Nr3c1 P065372EBI-492796, EBI-492753

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for compositional bias, region, domain, repeat.

TypeIDPosition(s)Description
Compositional bias1-22Polar residues
Region1-24Disordered
Domain50-138PPIase FKBP-type 1
Domain165-251PPIase FKBP-type 2
Repeat268-301TPR 1
Repeat317-350TPR 2
Repeat351-384TPR 3
Region421-456Disordered

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    456
  • Mass (Da)
    50,966
  • Last updated
    1996-11-01 v1
  • Checksum
    8FD0C9B61478EB46
MTTDEGTSNNGENPAATMTEQGEDITTKKDRGVLKIVKRVGTSDEAPMFGDKVYVHYKGMLSDGKKFDSSHDRKKPFAFSLGQGQVIKAWDIGVSTMKKGEICHLLCKPEYAYGSAGHLQKIPSNATLFFEIELLDFKGEDLFEDSGVIRRIKRKGEGYSNPNEGATVKVHLEGCCGGRTFDCRDVVFVVGEGEDHDIPIGIDKALVKMQREEQCILYLGPRYGFGEAGKPKFGIDPNAELMYEVTLKSFEKAKESWEMDTKEKLTQAAIVKEKGTVYFKGGKYTQAVIQYRKIVSWLEMEYGLSEKESKASESFLLAAFLNLAMCYLKLREYNKAVECCDKALGLDSANEKGLYRRGEAQLLMNDFESAKGDFEKVLAVNPQNRAARLQISMCQRKAKEHNERDRRVYANMFKKFAERDAKEEASKAGSKKAVEGAAGKQHESQAMEEGKAKGHV

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A3B2WBD2A0A3B2WBD2_MOUSEFkbp5248
A0A3B2WCL4A0A3B2WCL4_MOUSEFkbp593
B8JJC2B8JJC2_MOUSEFkbp5191

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1-22Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U36220
EMBL· GenBank· DDBJ
AAA89162.1
EMBL· GenBank· DDBJ
mRNA
U16959
EMBL· GenBank· DDBJ
AAA86983.1
EMBL· GenBank· DDBJ
mRNA
BC015260
EMBL· GenBank· DDBJ
AAH15260.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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