Q642N4 · Q642N4_XENTR

Function

Catalytic activity

  • (5S,12S)-dihydroxy-(6E,10E,12E,14Z)-eicosatetraenoate + NADP+ = 12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + H+ + NADPH
    This reaction proceeds in the forward direction.
  • 13,14-dihydro-15-oxo-PGF2alpha + NADP+ = 15-oxoprostaglandin F2alpha + H+ + NADPH
    This reaction proceeds in the backward direction.
  • 13,14-dihydro-15-oxo-prostaglandin E1 + NADP+ = 15-oxoprostaglandin E1 + H+ + NADPH
    This reaction proceeds in the backward direction.
  • 13,14-dihydro-15-oxo-prostaglandin F1alpha + NADP+ = 15-oxoprostaglandin F1alpha + H+ + NADPH
    This reaction proceeds in the backward direction.
  • 20-hydroxy-leukotriene B4 + NADP+ = 12-oxo-20-hydroxy-leukotriene B4 + H+ + NADPH
    This reaction proceeds in the forward direction.
  • 4-hydroxynonanal + NADP+ = (E)-4-hydroxynon-2-enal + H+ + NADPH
    This reaction proceeds in the backward direction.
  • 6-trans-leukotriene B4 + NADP+ = 12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + H+ + NADPH
    This reaction proceeds in the forward direction.
  • NADP+ + nonan-2-one = (3E)-nonen-2-one + H+ + NADPH
    This reaction proceeds in the backward direction.
  • NADP+ + octanal = (2E)-octenal + H+ + NADPH
    This reaction proceeds in the backward direction.
  • NADP+ + pentan-2-one = (E)-pent-3-en-2-one + H+ + NADPH
    This reaction proceeds in the backward direction.
  • an n-alkanal + NADP+ = an alk-2-enal + H+ + NADPH
    This reaction proceeds in the backward direction.
    EC:1.3.1.74 (UniProtKB | ENZYME | Rhea)
  • decanal + NADP+ = (2E)-decenal + H+ + NADPH
    This reaction proceeds in the backward direction.
  • dodecanal + NADP+ = (2E)-dodecenal + H+ + NADPH
    This reaction proceeds in the backward direction.
  • hexanal + NADP+ = (E)-hex-2-enal + H+ + NADPH
    This reaction proceeds in the backward direction.
  • leukotriene B4 + NADP+ = 12-oxo-leukotriene B4 + H+ + NADPH
    This reaction proceeds in the forward direction.

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Function13-prostaglandin reductase activity
Molecular Function15-oxoprostaglandin 13-oxidase activity
Molecular Function2-alkenal reductase [NAD(P)+] activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Prostaglandin reductase 1
  • EC number
  • Alternative names
    • 15-oxoprostaglandin 13-reductase
    • Dithiolethione-inducible gene 1 protein
    • Leukotriene B4 12-hydroxydehydrogenase
    • NAD(P)H-dependent alkenal/one oxidoreductase

Gene names

    • Name
      ptgr1
    • Synonyms
      ltb4dh

Organism names

Accessions

  • Primary accession
    Q642N4

Proteomes

Organism-specific databases

Subcellular Location

PTM/Processing

Keywords

Interaction

Subunit

Monomer or homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain15-327Enoyl reductase (ER)

Sequence similarities

Belongs to the NADP-dependent oxidoreductase L4BD family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    329
  • Mass (Da)
    35,907
  • Last updated
    2004-10-25 v1
  • Checksum
    4799AEB0D3DDEE8A
MVIAKSWTMVRHFEGAPQPEDFKLIENELPPLKDGEVLLESEFLSVDPYMRPYSKMKLKEGDVIMGSQVARVIESKNPAVPVGGYYVAFAGWTTHFISDGQGLAPLPSSWPENLPKSLALGAAGMPGLTAYFGLLELCNPKEGDVVLVNAAAGAVGSLVGQIAKIKGCKAVGCAGSDDKVGFLKEIGFDEAFNYKTVSSLAEALKKASPEGYDCYFENVGGKFADTALQQMKDFGRIAVCGAISLYNDSVPSTGPYIQPYILFKQLRMEGFLVTRWQDRYPEGQKQLLQWIIEGKLKYHEHITNGFENMPAGFMGMLKGENIGKAIIKV

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BC081301
EMBL· GenBank· DDBJ
AAH81301.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp