Q64249 · NR6A1_MOUSE

  • Protein
    Nuclear receptor subfamily 6 group A member 1
  • Gene
    Nr6a1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Orphan nuclear receptor. Binds to a response element containing the sequence 5'-TCAAGGTCA-3'. May be involved in the regulation of gene expression in germ cell development during gametogenesis.

Features

Showing features for dna binding.

149550100150200250300350400450
TypeIDPosition(s)Description
DNA binding72-147Nuclear receptor

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentchromatin
Cellular Componentnucleus
Cellular Componenttranscription regulator complex
Molecular FunctionDNA-binding transcription activator activity, RNA polymerase II-specific
Molecular Functionestrogen response element binding
Molecular Functionnuclear receptor activity
Molecular Functionprotein homodimerization activity
Molecular FunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Functionsequence-specific DNA binding
Molecular Functionzinc ion binding
Biological Processcell differentiation
Biological Processgamete generation
Biological Processnegative regulation of transcription by RNA polymerase II
Biological Processpositive regulation of transcription by RNA polymerase II
Biological Processregulation of transcription by RNA polymerase II
Biological Processspermatogenesis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Nuclear receptor subfamily 6 group A member 1
  • Alternative names
    • Germ cell nuclear factor (GCNF; mGCNF)
    • Retinoid receptor-related testis-specific receptor (RTR)

Gene names

    • Name
      Nr6a1
    • Synonyms
      Gcnf

Organism names

  • Taxonomic identifier
  • Strains
    • BALB/cJ
    • CD-1
    • 129/SvJ
    • 129/Ola
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q64249
  • Secondary accessions
    • A2AQL8
    • A2AQM1
    • Q687Z3

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Phenotypes & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis246-247Abolishes interaction with RXRIP110.
Mutagenesis254-255Does not abolish interaction with RXRIP110.
Mutagenesis265-266Does not abolish interaction with RXRIP110.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 17 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000537421-495Nuclear receptor subfamily 6 group A member 1

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in the germ cells of both the adult testis and ovary, being most abundant in spermatids.

Gene expression databases

Interaction

Subunit

Homodimer. Interacts with UIMC1.

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for region, zinc finger, compositional bias, domain.

TypeIDPosition(s)Description
Region1-34Disordered
Zinc finger75-95NR C4-type
Zinc finger111-135NR C4-type
Region145-165Disordered
Region177-214Disordered
Region187-268Sufficient for interaction with UIMC1
Compositional bias188-214Polar residues
Domain264-495NR LBD

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (3)
  • Sequence status
    Complete

This entry describes 3 isoforms produced by Alternative splicing.

Q64249-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    495
  • Mass (Da)
    55,976
  • Last updated
    1996-11-01 v1
  • Checksum
    ECB0AB3E99E42661
MERDERPPSGGGGGGGSAGFLEPPAALPPPPRNGFCQDELAELDPGTNGETDSLTLGQGHIPVSVPDDRAEQRTCLICGDRATGLHYGIISCEGCKGFFKRSICNKRVYRCSRDKNCVMSRKQRNRCQYCRLLKCLQMGMNRKAIREDGMPGGRNKSIGPVQISEEEIERIMSGQEFEEEANHWSNHGDSDHSSPGNRASESNQPSPGSTLSSSRSVELNGFMAFRDQYMGMSVPPHYQYIPHLFSYSGHSPLLPPQARSLDPQSYSLIHQLMSAEDLEPLGTPMLIEDGYAVTQAELFALLCRLADELLFRQIAWIKKLPFFCELSIKDYTCLLSSTWQELILLSSLTVYSKQIFGELADVTAKYSPSDEELHRFSDEGMEVIERLIYLYHKFHQLKVSNEEYACMKAINFLNQDIRGLTSASQLEQLNKRYWYICQDFTEYKYTHQPNRFPDLMMCLPEIRYIAGKMVNVPLEQLPLLFKVVLHSCKTSTVKE

Q64249-2

Q64249-3

  • Name
    3
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
Z4YMW4Z4YMW4_MOUSENr6a1235
A0A0A0MQG4A0A0A0MQG4_MOUSENr6a1220

Features

Showing features for alternative sequence, compositional bias.

TypeIDPosition(s)Description
Alternative sequenceVSP_0259281-57in isoform 3
Alternative sequenceVSP_02592948-62in isoform 2
Alternative sequenceVSP_02593058-62in isoform 3
Alternative sequenceVSP_02593163in isoform 2
Compositional bias188-214Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U14666
EMBL· GenBank· DDBJ
AAA92682.1
EMBL· GenBank· DDBJ
mRNA
U09563
EMBL· GenBank· DDBJ
AAA64746.1
EMBL· GenBank· DDBJ
mRNA
AF254821
EMBL· GenBank· DDBJ
AAG24485.1
EMBL· GenBank· DDBJ
Genomic DNA
AF254575
EMBL· GenBank· DDBJ
AAG24485.1
EMBL· GenBank· DDBJ
Genomic DNA
AF254815
EMBL· GenBank· DDBJ
AAG24485.1
EMBL· GenBank· DDBJ
Genomic DNA
AF254816
EMBL· GenBank· DDBJ
AAG24485.1
EMBL· GenBank· DDBJ
Genomic DNA
AF254817
EMBL· GenBank· DDBJ
AAG24485.1
EMBL· GenBank· DDBJ
Genomic DNA
AF254818
EMBL· GenBank· DDBJ
AAG24485.1
EMBL· GenBank· DDBJ
Genomic DNA
AF254819
EMBL· GenBank· DDBJ
AAG24485.1
EMBL· GenBank· DDBJ
Genomic DNA
AF254820
EMBL· GenBank· DDBJ
AAG24485.1
EMBL· GenBank· DDBJ
Genomic DNA
AF390896
EMBL· GenBank· DDBJ
AAM55193.1
EMBL· GenBank· DDBJ
mRNA
AF390900
EMBL· GenBank· DDBJ
AAM95878.1
EMBL· GenBank· DDBJ
Genomic DNA
AF390897
EMBL· GenBank· DDBJ
AAM95878.1
EMBL· GenBank· DDBJ
Genomic DNA
AF390898
EMBL· GenBank· DDBJ
AAM95878.1
EMBL· GenBank· DDBJ
Genomic DNA
AF390899
EMBL· GenBank· DDBJ
AAM95878.1
EMBL· GenBank· DDBJ
Genomic DNA
AL844842
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AL935155
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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