Q64249 · NR6A1_MOUSE
- ProteinNuclear receptor subfamily 6 group A member 1
- GeneNr6a1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids495 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Orphan nuclear receptor. Binds to a response element containing the sequence 5'-TCAAGGTCA-3'. May be involved in the regulation of gene expression in germ cell development during gametogenesis.
Features
Showing features for dna binding.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
DNA binding | 72-147 | Nuclear receptor | ||||
Sequence: QRTCLICGDRATGLHYGIISCEGCKGFFKRSICNKRVYRCSRDKNCVMSRKQRNRCQYCRLLKCLQMGMNRKAIRE |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | chromatin | |
Cellular Component | nucleus | |
Cellular Component | transcription regulator complex | |
Molecular Function | DNA-binding transcription activator activity, RNA polymerase II-specific | |
Molecular Function | estrogen response element binding | |
Molecular Function | nuclear receptor activity | |
Molecular Function | protein homodimerization activity | |
Molecular Function | RNA polymerase II cis-regulatory region sequence-specific DNA binding | |
Molecular Function | sequence-specific DNA binding | |
Molecular Function | zinc ion binding | |
Biological Process | cell differentiation | |
Biological Process | gamete generation | |
Biological Process | negative regulation of transcription by RNA polymerase II | |
Biological Process | positive regulation of transcription by RNA polymerase II | |
Biological Process | regulation of transcription by RNA polymerase II | |
Biological Process | spermatogenesis |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNuclear receptor subfamily 6 group A member 1
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ64249
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Phenotypes & Variants
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Mutagenesis | 246-247 | Abolishes interaction with RXRIP110. | ||||
Sequence: SY → GG | ||||||
Mutagenesis | 254-255 | Does not abolish interaction with RXRIP110. | ||||
Sequence: LP → AA | ||||||
Mutagenesis | 265-266 | Does not abolish interaction with RXRIP110. | ||||
Sequence: SY → AA |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 17 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000053742 | 1-495 | Nuclear receptor subfamily 6 group A member 1 | |||
Sequence: MERDERPPSGGGGGGGSAGFLEPPAALPPPPRNGFCQDELAELDPGTNGETDSLTLGQGHIPVSVPDDRAEQRTCLICGDRATGLHYGIISCEGCKGFFKRSICNKRVYRCSRDKNCVMSRKQRNRCQYCRLLKCLQMGMNRKAIREDGMPGGRNKSIGPVQISEEEIERIMSGQEFEEEANHWSNHGDSDHSSPGNRASESNQPSPGSTLSSSRSVELNGFMAFRDQYMGMSVPPHYQYIPHLFSYSGHSPLLPPQARSLDPQSYSLIHQLMSAEDLEPLGTPMLIEDGYAVTQAELFALLCRLADELLFRQIAWIKKLPFFCELSIKDYTCLLSSTWQELILLSSLTVYSKQIFGELADVTAKYSPSDEELHRFSDEGMEVIERLIYLYHKFHQLKVSNEEYACMKAINFLNQDIRGLTSASQLEQLNKRYWYICQDFTEYKYTHQPNRFPDLMMCLPEIRYIAGKMVNVPLEQLPLLFKVVLHSCKTSTVKE |
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed in the germ cells of both the adult testis and ovary, being most abundant in spermatids.
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, zinc finger, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-34 | Disordered | ||||
Sequence: MERDERPPSGGGGGGGSAGFLEPPAALPPPPRNG | ||||||
Zinc finger | 75-95 | NR C4-type | ||||
Sequence: CLICGDRATGLHYGIISCEGC | ||||||
Zinc finger | 111-135 | NR C4-type | ||||
Sequence: CSRDKNCVMSRKQRNRCQYCRLLKC | ||||||
Region | 145-165 | Disordered | ||||
Sequence: IREDGMPGGRNKSIGPVQISE | ||||||
Region | 177-214 | Disordered | ||||
Sequence: FEEEANHWSNHGDSDHSSPGNRASESNQPSPGSTLSSS | ||||||
Region | 187-268 | Sufficient for interaction with UIMC1 | ||||
Sequence: HGDSDHSSPGNRASESNQPSPGSTLSSSRSVELNGFMAFRDQYMGMSVPPHYQYIPHLFSYSGHSPLLPPQARSLDPQSYSL | ||||||
Compositional bias | 188-214 | Polar residues | ||||
Sequence: GDSDHSSPGNRASESNQPSPGSTLSSS | ||||||
Domain | 264-495 | NR LBD | ||||
Sequence: QSYSLIHQLMSAEDLEPLGTPMLIEDGYAVTQAELFALLCRLADELLFRQIAWIKKLPFFCELSIKDYTCLLSSTWQELILLSSLTVYSKQIFGELADVTAKYSPSDEELHRFSDEGMEVIERLIYLYHKFHQLKVSNEEYACMKAINFLNQDIRGLTSASQLEQLNKRYWYICQDFTEYKYTHQPNRFPDLMMCLPEIRYIAGKMVNVPLEQLPLLFKVVLHSCKTSTVKE |
Sequence similarities
Belongs to the nuclear hormone receptor family. NR6 subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 3 isoforms produced by Alternative splicing.
Q64249-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length495
- Mass (Da)55,976
- Last updated1996-11-01 v1
- ChecksumECB0AB3E99E42661
Q64249-2
- Name2
Q64249-3
- Name3
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Z4YMW4 | Z4YMW4_MOUSE | Nr6a1 | 235 | ||
A0A0A0MQG4 | A0A0A0MQG4_MOUSE | Nr6a1 | 220 |
Features
Showing features for alternative sequence, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_025928 | 1-57 | in isoform 3 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_025929 | 48-62 | in isoform 2 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_025930 | 58-62 | in isoform 3 | |||
Sequence: QGHIP → METWE | ||||||
Alternative sequence | VSP_025931 | 63 | in isoform 2 | |||
Sequence: V → I | ||||||
Compositional bias | 188-214 | Polar residues | ||||
Sequence: GDSDHSSPGNRASESNQPSPGSTLSSS |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
U14666 EMBL· GenBank· DDBJ | AAA92682.1 EMBL· GenBank· DDBJ | mRNA | ||
U09563 EMBL· GenBank· DDBJ | AAA64746.1 EMBL· GenBank· DDBJ | mRNA | ||
AF254821 EMBL· GenBank· DDBJ | AAG24485.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF254575 EMBL· GenBank· DDBJ | AAG24485.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF254815 EMBL· GenBank· DDBJ | AAG24485.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF254816 EMBL· GenBank· DDBJ | AAG24485.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF254817 EMBL· GenBank· DDBJ | AAG24485.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF254818 EMBL· GenBank· DDBJ | AAG24485.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF254819 EMBL· GenBank· DDBJ | AAG24485.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF254820 EMBL· GenBank· DDBJ | AAG24485.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF390896 EMBL· GenBank· DDBJ | AAM55193.1 EMBL· GenBank· DDBJ | mRNA | ||
AF390900 EMBL· GenBank· DDBJ | AAM95878.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF390897 EMBL· GenBank· DDBJ | AAM95878.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF390898 EMBL· GenBank· DDBJ | AAM95878.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF390899 EMBL· GenBank· DDBJ | AAM95878.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AL844842 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL935155 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |