Q64205 · DLX3_MOUSE

  • Protein
    Homeobox protein DLX-3
  • Gene
    Dlx3
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Transcriptional activator (PubMed:23371388).
Activates transcription of GNRHR, via binding to the downstream activin regulatory element (DARE) in the gene promoter (PubMed:23371388).

Features

Showing features for dna binding.

128720406080100120140160180200220240260280
TypeIDPosition(s)Description
DNA binding129-188Homeobox

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleus
Molecular Functionchromatin binding
Molecular FunctionDNA binding
Molecular FunctionDNA-binding transcription activator activity, RNA polymerase II-specific
Molecular FunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Functiontranscription cis-regulatory region binding
Biological Processblood vessel development
Biological ProcessBMP signaling pathway
Biological Processgene expression
Biological Processhair cell differentiation
Biological Processhair cycle
Biological Processhair follicle cell proliferation
Biological Processhair follicle development
Biological Processhair follicle morphogenesis
Biological Processodontoblast differentiation
Biological Processodontogenesis of dentin-containing tooth
Biological Processplacenta development
Biological Processpositive regulation of transcription by RNA polymerase II
Biological ProcessWnt signaling pathway

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Homeobox protein DLX-3

Gene names

    • Name
      Dlx3

Organism names

  • Taxonomic identifier
  • Strains
    • FVB/N
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q64205

Proteomes

Organism-specific databases

Subcellular Location

Nucleus
Cytoplasm

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000490271-287Homeobox protein DLX-3

Proteomic databases

PTM databases

Expression

Developmental stage

Not expressed in the central nervous system at 16.5 dpc (PubMed:7893603).
Initially expressed in the branchial arches at 9.5 dpc, expression is confined to the caudal portion of the mandibular process at 10.5 dpc (PubMed:7893603).
Distally expressed in the posterior regions of the first and second branchial arches at 10.5 dpc (PubMed:7893603).
Expressed in the auditory hillocks, ventral olfactory bulbs, the oral epithelium and the external naris at 12.5 dpc (PubMed:7893603).
Expressed in the area under the first branchial cleft from which the external ear develops, in cell adjacent to Meckel's cartilage, in the external naris and mesenchymal cells that enclose the nasal epithelium at 13.5 dpc (PubMed:7893603).
Expressed in the developing otic vesicle at 11.5 dpc, expression is then restricted to the vestibular region at 12.5 dpc and further restricted to the epithelium of the utricle and the semicircular canals at 13.5 dpc (PubMed:7893603).
Expression declines thereafter with no expression detected in the developing inner ear at 14.5 dpc (PubMed:7893603).
Expressed in the mesenchyme of the dental papilla at 13.5 dpc, expression remains in ameloblasts and odontoblasts at 16.5 dpc (PubMed:7893603).
Expressed in a patchy pattern in the epithelium of the upper lip at 12.5 dpc, expression is increased in follicles during whisker development from 14.5 dpc until birth (PubMed:7893603).

Gene expression databases

Interaction

Subunit

Heterodimer with MEIS1 (By similarity).
Interacts with IPO7; the interaction facilitates nuclear translocation of DLX3 in dental papilla cells (PubMed:35922041).

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for region, compositional bias.

Type
IDPosition(s)Description
Region131-181Interaction with DNA
Compositional bias195-225Polar residues
Region195-287Disordered
Compositional bias226-240Pro residues
Compositional bias242-271Polar residues
Compositional bias272-287Pro residues

Sequence similarities

Belongs to the distal-less homeobox family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    287
  • Mass (Da)
    31,791
  • Last updated
    1996-11-01 v1
  • Checksum
    1F7DB917FC4C2158
MSGSFDRKLSSILTDISSSLSCHAGSKDSPTLPESTVTDLGYYSAPQHDYYSGQPYGQTVNPYTYHHQFNLNGLAGTGAYSPKSEYTYGGSYRQYGAYREQPLPAQDPVSVKEEPEAEVRMVNGKPKKVRKPRTIYSSYQLAALQRRFQKAQYLALPERAELAAQLGLTQTQVKIWFQNRRSKFKKLYKNGEVPLEHSPNNSDSMACNSPPSPALWDTSSHSTPAPARNPLPPPLPYSASPNYLDDPTNSWYHTQNLSGPHLQQQPPQPATLHHASPGPPPNPGAVY

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias195-225Polar residues
Compositional bias226-240Pro residues
Compositional bias242-271Polar residues
Compositional bias272-287Pro residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
S81932
EMBL· GenBank· DDBJ
AAB33879.1
EMBL· GenBank· DDBJ
mRNA
BC058852
EMBL· GenBank· DDBJ
AAH58852.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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