Q64205 · DLX3_MOUSE
- ProteinHomeobox protein DLX-3
- GeneDlx3
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids287 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Transcriptional activator (PubMed:23371388).
Activates transcription of GNRHR, via binding to the downstream activin regulatory element (DARE) in the gene promoter (PubMed:23371388).
Activates transcription of GNRHR, via binding to the downstream activin regulatory element (DARE) in the gene promoter (PubMed:23371388).
Features
Showing features for dna binding.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
DNA binding | 129-188 | Homeobox | |||
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | nucleus | |
Molecular Function | chromatin binding | |
Molecular Function | DNA binding | |
Molecular Function | DNA-binding transcription activator activity, RNA polymerase II-specific | |
Molecular Function | RNA polymerase II cis-regulatory region sequence-specific DNA binding | |
Molecular Function | transcription cis-regulatory region binding | |
Biological Process | blood vessel development | |
Biological Process | BMP signaling pathway | |
Biological Process | gene expression | |
Biological Process | hair cell differentiation | |
Biological Process | hair cycle | |
Biological Process | hair follicle cell proliferation | |
Biological Process | hair follicle development | |
Biological Process | hair follicle morphogenesis | |
Biological Process | odontoblast differentiation | |
Biological Process | odontogenesis of dentin-containing tooth | |
Biological Process | placenta development | |
Biological Process | positive regulation of transcription by RNA polymerase II | |
Biological Process | Wnt signaling pathway |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameHomeobox protein DLX-3
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ64205
Proteomes
Organism-specific databases
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000049027 | 1-287 | Homeobox protein DLX-3 | ||
Proteomic databases
PTM databases
Expression
Developmental stage
Not expressed in the central nervous system at 16.5 dpc (PubMed:7893603).
Initially expressed in the branchial arches at 9.5 dpc, expression is confined to the caudal portion of the mandibular process at 10.5 dpc (PubMed:7893603).
Distally expressed in the posterior regions of the first and second branchial arches at 10.5 dpc (PubMed:7893603).
Expressed in the auditory hillocks, ventral olfactory bulbs, the oral epithelium and the external naris at 12.5 dpc (PubMed:7893603).
Expressed in the area under the first branchial cleft from which the external ear develops, in cell adjacent to Meckel's cartilage, in the external naris and mesenchymal cells that enclose the nasal epithelium at 13.5 dpc (PubMed:7893603).
Expressed in the developing otic vesicle at 11.5 dpc, expression is then restricted to the vestibular region at 12.5 dpc and further restricted to the epithelium of the utricle and the semicircular canals at 13.5 dpc (PubMed:7893603).
Expression declines thereafter with no expression detected in the developing inner ear at 14.5 dpc (PubMed:7893603).
Expressed in the mesenchyme of the dental papilla at 13.5 dpc, expression remains in ameloblasts and odontoblasts at 16.5 dpc (PubMed:7893603).
Expressed in a patchy pattern in the epithelium of the upper lip at 12.5 dpc, expression is increased in follicles during whisker development from 14.5 dpc until birth (PubMed:7893603).
Initially expressed in the branchial arches at 9.5 dpc, expression is confined to the caudal portion of the mandibular process at 10.5 dpc (PubMed:7893603).
Distally expressed in the posterior regions of the first and second branchial arches at 10.5 dpc (PubMed:7893603).
Expressed in the auditory hillocks, ventral olfactory bulbs, the oral epithelium and the external naris at 12.5 dpc (PubMed:7893603).
Expressed in the area under the first branchial cleft from which the external ear develops, in cell adjacent to Meckel's cartilage, in the external naris and mesenchymal cells that enclose the nasal epithelium at 13.5 dpc (PubMed:7893603).
Expressed in the developing otic vesicle at 11.5 dpc, expression is then restricted to the vestibular region at 12.5 dpc and further restricted to the epithelium of the utricle and the semicircular canals at 13.5 dpc (PubMed:7893603).
Expression declines thereafter with no expression detected in the developing inner ear at 14.5 dpc (PubMed:7893603).
Expressed in the mesenchyme of the dental papilla at 13.5 dpc, expression remains in ameloblasts and odontoblasts at 16.5 dpc (PubMed:7893603).
Expressed in a patchy pattern in the epithelium of the upper lip at 12.5 dpc, expression is increased in follicles during whisker development from 14.5 dpc until birth (PubMed:7893603).
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 131-181 | Interaction with DNA | |||
Compositional bias | 195-225 | Polar residues | |||
Region | 195-287 | Disordered | |||
Compositional bias | 226-240 | Pro residues | |||
Compositional bias | 242-271 | Polar residues | |||
Compositional bias | 272-287 | Pro residues | |||
Sequence similarities
Belongs to the distal-less homeobox family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length287
- Mass (Da)31,791
- Last updated1996-11-01 v1
- Checksum1F7DB917FC4C2158
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 195-225 | Polar residues | |||
Compositional bias | 226-240 | Pro residues | |||
Compositional bias | 242-271 | Polar residues | |||
Compositional bias | 272-287 | Pro residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
S81932 EMBL· GenBank· DDBJ | AAB33879.1 EMBL· GenBank· DDBJ | mRNA | ||
BC058852 EMBL· GenBank· DDBJ | AAH58852.1 EMBL· GenBank· DDBJ | mRNA |