Q64201 · OTX2_RAT

  • Protein
    Homeobox protein OTX2
  • Gene
    Otx2
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    5/5

Function

function

Transcription factor probably involved in the development of the brain and the sense organs. Can bind to the bicoid/BCD target sequence (BTS): 5'-TCTAATCCC-3'.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentgrowth cone
Cellular Componentnucleus
Cellular Componentprotein-containing complex
Cellular Componenttranscription regulator complex
Molecular FunctionDNA-binding transcription activator activity, RNA polymerase II-specific
Molecular FunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Functionsequence-specific double-stranded DNA binding
Biological Processanimal organ morphogenesis
Biological Processanterior/posterior pattern specification
Biological Processaxon guidance
Biological Processcell fate commitment
Biological Processcellular response to leukemia inhibitory factor
Biological Processcentral nervous system development
Biological Processdiencephalon morphogenesis
Biological Processdopaminergic neuron differentiation
Biological Processdorsal/ventral pattern formation
Biological Processendoderm development
Biological Processeye photoreceptor cell fate commitment
Biological Processforebrain development
Biological Processinner ear morphogenesis
Biological Processmesendoderm development
Biological Processmetencephalon development
Biological Processmidbrain development
Biological Processneuroepithelial cell differentiation
Biological Processneuron fate commitment
Biological Processneuron fate determination
Biological Processneuron fate specification
Biological Processoligodendrocyte differentiation
Biological Processpositive regulation of DNA-templated transcription
Biological Processpositive regulation of embryonic development
Biological Processpositive regulation of gastrulation
Biological Processpositive regulation of transcription by RNA polymerase II
Biological Processprimitive streak formation
Biological Processprotein-containing complex assembly
Biological Processregulation of transcription by RNA polymerase II
Biological Processsomite rostral/caudal axis specification
Biological Processtelencephalon regionalization

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Homeobox protein OTX2
  • Alternative names
    • Orthodenticle homolog 2

Gene names

    • Name
      Otx2

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    Q64201

Proteomes

Organism-specific databases

Subcellular Location

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000492121-70Homeobox protein OTX2

Proteomic databases

Expression

Induction

Up-regulated by FGF2 treatment in embryonic telencephalon primary cultures.

Developmental stage

Expressed in the dorsal and basal telencephalon, in a subpopulation of proliferating neuroblasts, early in development (at least from 11.5 dpc).

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region34-70Disordered
Compositional bias45-70Polar residues

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    70
  • Mass (Da)
    7,139
  • Last updated
    1996-11-01 v1
  • Checksum
    4CE56B48E00E4120
MTYTQASGYSQGYAGSTSYFGGMDCGSYLTPMHHQLPGPGATLSPMGTNAVTSHLNQSPASLSTQGYGAS

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
M0R4H6M0R4H6_RATOtx2297
F2Z3S7F2Z3S7_RATOtx2289

Features

Showing features for non-terminal residue, compositional bias.

TypeIDPosition(s)Description
Non-terminal residue1
Compositional bias45-70Polar residues
Non-terminal residue70

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
S81922
EMBL· GenBank· DDBJ
AAP32271.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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