Q64028 · PHC1_MOUSE

  • Protein
    Polyhomeotic-like protein 1
  • Gene
    Phc1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Required for proper control of cellular levels of GMNN expression (By similarity).

Features

Showing features for binding site.

110101002003004005006007008009001,000
TypeIDPosition(s)Description
Binding site806Zn2+ (UniProtKB | ChEBI)
Binding site809Zn2+ (UniProtKB | ChEBI)
Binding site825Zn2+ (UniProtKB | ChEBI)
Binding site829Zn2+ (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnuclear body
Cellular Componentnucleus
Cellular ComponentPRC1 complex
Cellular Componentsex chromatin
Molecular Functionchromatin binding
Molecular FunctionDNA binding
Molecular Functionhistone binding
Molecular Functionzinc ion binding
Biological Processcellular response to leukemia inhibitory factor
Biological Processcellular response to retinoic acid
Biological Processchromatin remodeling
Biological Processnegative regulation of DNA-templated transcription

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Polyhomeotic-like protein 1
  • Short names
    mPH1
  • Alternative names
    • Early development regulatory protein 1
    • RAE-28

Gene names

    • Name
      Phc1
    • Synonyms
      Edr, Edr1, Rae28

Organism names

  • Taxonomic identifier
  • Strains
    • BALB/cJ
    • C57BL/6J
    • NMRI
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q64028
  • Secondary accessions
    • P70359
    • Q64307
    • Q7TT35
    • Q8BZ80

Proteomes

Organism-specific databases

Subcellular Location

PTM/Processing

Features

Showing features for chain, modified residue, cross-link.

TypeIDPosition(s)Description
ChainPRO_00000583761-1010Polyhomeotic-like protein 1
Modified residue651Phosphoserine
Cross-link769Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)
Modified residue904Phosphoserine
Modified residue928Phosphothreonine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Highly expressed in testis with lower levels in most other tissues. Expressed in embryonic stem cells (PubMed:22226355).

Induction

By retinoic acid.

Developmental stage

Expressed ubiquitously in 8.5 dpc embryos. At 10.5 dpc, strongly expressed in pharyngeal arches and weakly expressed in heart. By 14.5 dpc, expression is detected throughout the central nervous system.

Gene expression databases

Interaction

Subunit

Homodimer. Component of a PRC1-like complex (By similarity).
Interacts with the SAM domain of SCMH1 via its SAM domain in vitro (PubMed:10653359).
Interacts with RNF2 and CBX7 (PubMed:22226355).
Interacts with PHC2 (PubMed:16024804).
Interacts with BMI1 (PubMed:9009205).

Binary interactions

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for region, compositional bias, zinc finger, domain.

TypeIDPosition(s)Description
Region1-25Disordered
Region212-243Disordered
Compositional bias259-273Polar residues
Region259-312Disordered
Region444-506Disordered
Compositional bias464-485Polar residues
Compositional bias486-506Pro residues
Region565-588Disordered
Compositional bias570-584Polar residues
Region646-678Disordered
Region772-794Disordered
Zinc finger797-831FCS-type
Compositional bias854-892Basic and acidic residues
Region854-928Disordered
Domain946-1010SAM

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (3)
  • Sequence status
    Complete

This entry describes 3 isoforms produced by Alternative splicing.

Q64028-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    1,010
  • Mass (Da)
    106,060
  • Last updated
    2022-12-14 v3
  • Checksum
    086BB97C290243C8
METESEQNSSSTNGSSSSGASSRPQIAQMSLYERQAVQALQALQRQPNAAQYFHQFMLQQQLSNAQLHSLAAVQQATIAASRQASSPNSSTAQQQTATTQASMNLATTSAAQLISRSQSVSSPSATTLTQSVLLGNTTSPPLNQSQAQMYLRPQLGNLLQVNRTLGRNVPLASQLILMPNGAVAAVQQEVPPAQSPGVHADADQVQNLAVRNQQASAQGPQMPGSTQKAIPPGASPVSGLSQTSSQALAVAQASSGASGQSLNLSQAGGGSGNSLPGSMGPGGGGQAPGGLGQLPSSGLTGGSCPRKGTGVVQPLPAAQTVTVSQGSQTEAESAAAKKAEADGSGQQSVGMNLTRTATPAPSQTLISSATYTQIQPHSLIQQQQQIHLQQKQVVIQQQIAIHHQQQFQHRQSQLLHTATHLQLAQQQQQQQQQQQQQQQQQQQQQQGTTLTAPQPPQVPPTQQVPPSQSQQQAQTLVVQPMLQSSPLTLPPEPTSKPPIPIQSKPPVAPIKPPQLGAAKMSATQQPPPHIPVQVVGTRQPGSAQAQALGLAQLAAAVPTPRGITGAVQPGQAHLASSPPSSQAAPGALQECPPALAAGMTLAPVQGTAHVVKGGPTASSPVVAQVPAAFYMQSVHLPGKAQTLAVKRKAESEEERDDLSALASVLPTKASPAAESPKVIEEKNSLGEKAEPVASLNANPPNSDLVALAPTPSAPPPTLALVSRQMGDSKPPQAIVKPQILTHIIEGFVIQEGAEPFPVGCSQFLKETKKPLQAGLPTGLNESQPSGPLGGDSPSVELEKKANLLKCEYCGKYAPAEQFRGSKRFCSMTCAKRYNVSCSHQFRLKRKKMKEFQEASYARVRRRGPRRSSSDIARAKIQGKRHRGQEDSSRGSDNSSYDEALSPTSPGPLSVRAGHGERDLGNTITTPSTPELQGINPVFLSSNPSQWSVEEVYEFIASLQGCQEIAEEFRSQEIDGQALLLLKEEHLMSAMNIKLGPALKICAKINVLKET

Q64028-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Q64028-3

  • Name
    3
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There are 8 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
F7D980F7D980_MOUSEPhc169
Q3V116Q3V116_MOUSEPhc1958
E0CYV8E0CYV8_MOUSEPhc186
E0CYR2E0CYR2_MOUSEPhc180
E0CXC9E0CXC9_MOUSEPhc1117
E0CXA6E0CXA6_MOUSEPhc179
E0CXT0E0CXT0_MOUSEPhc1205
E0CXV8E0CXV8_MOUSEPhc1965

Features

Showing features for sequence conflict, alternative sequence, compositional bias.

TypeIDPosition(s)Description
Sequence conflict127in Ref. 2; AAC28974
Sequence conflict131in Ref. 2; AAC28974
Alternative sequenceVSP_004040153-159in isoform 2
Alternative sequenceVSP_004041153-204in isoform 3
Compositional bias259-273Polar residues
Sequence conflict401in Ref. 1; AAB31766
Sequence conflict446in Ref. 1; AAB31766, 4; AAH46535 and 2; AAC28974
Compositional bias464-485Polar residues
Compositional bias486-506Pro residues
Compositional bias570-584Polar residues
Sequence conflict768in Ref. 1; AAB31766, 4; AAH46535 and 2; AAC28974
Compositional bias854-892Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
S73882
EMBL· GenBank· DDBJ
AAB31766.1
EMBL· GenBank· DDBJ
mRNA
U63386
EMBL· GenBank· DDBJ
AAC28974.1
EMBL· GenBank· DDBJ
mRNA
AC153579
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC046535
EMBL· GenBank· DDBJ
AAH46535.1
EMBL· GenBank· DDBJ
mRNA
BC052394
EMBL· GenBank· DDBJ
AAH52394.1
EMBL· GenBank· DDBJ
mRNA
AK036370
EMBL· GenBank· DDBJ
BAC29400.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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