Q63ZW2 · MC25A_DANRE
- ProteinMICOS complex subunit mic25a
- Genechchd6a
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids239 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | MICOS complex | |
Cellular Component | mitochondrial inner membrane | |
Cellular Component | mitochondrion | |
Biological Process | cristae formation | |
Biological Process | DNA damage response | |
Biological Process | inner mitochondrial membrane organization |
Names & Taxonomy
Protein names
- Recommended nameMICOS complex subunit mic25a
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionQ63ZW2
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion inner membrane ; Lipid-anchor
Keywords
- Cellular component
PTM/Processing
Features
Showing features for initiator methionine, lipidation, chain, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Initiator methionine | 1 | Removed | ||||
Sequence: M | ||||||
Lipidation | 2 | N-myristoyl glycine | ||||
Sequence: G | ||||||
Chain | PRO_0000416910 | 2-239 | MICOS complex subunit mic25a | |||
Sequence: GSGESTTRRVSFGLDEDDRVRILRGVKLSEDVLQRMRNTNADPRPPANNKENQGHQTRTPSTSDAQAPKTQAKTTFPDSKEELKKRYEQQQAIIQEELARIARKEREAARQDISRAVQRERAQTRQESERAKQLGKQLDKKEAELKALEAFYQEQITQLEKKNEERFRMSAEQFHAAATRSEANIKARNVEPVCLNLQAQILNCYRENREQTLQCSDLAKEYMQCINAAKKNLLVNHG | ||||||
Disulfide bond | 195↔226 | |||||
Sequence: CLNLQAQILNCYRENREQTLQCSDLAKEYMQC | ||||||
Disulfide bond | 205↔216 | |||||
Sequence: CYRENREQTLQC |
Keywords
- PTM
Proteomic databases
Expression
Gene expression databases
Interaction
Subunit
Component of the mitochondrial contact site and cristae organizing system (MICOS) complex (also known as MINOS or MitOS complex).
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, coiled coil, domain, motif.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 27-88 | Disordered | ||||
Sequence: VKLSEDVLQRMRNTNADPRPPANNKENQGHQTRTPSTSDAQAPKTQAKTTFPDSKEELKKRY | ||||||
Compositional bias | 34-75 | Polar residues | ||||
Sequence: LQRMRNTNADPRPPANNKENQGHQTRTPSTSDAQAPKTQAKT | ||||||
Coiled coil | 79-166 | |||||
Sequence: DSKEELKKRYEQQQAIIQEELARIARKEREAARQDISRAVQRERAQTRQESERAKQLGKQLDKKEAELKALEAFYQEQITQLEKKNEE | ||||||
Region | 113-133 | Disordered | ||||
Sequence: DISRAVQRERAQTRQESERAK | ||||||
Domain | 192-234 | CHCH | ||||
Sequence: EPVCLNLQAQILNCYRENREQTLQCSDLAKEYMQCINAAKKNL | ||||||
Motif | 195-205 | Cx9C motif 1 | ||||
Sequence: CLNLQAQILNC | ||||||
Motif | 216-226 | Cx9C motif 2 | ||||
Sequence: CSDLAKEYMQC |
Sequence similarities
Belongs to the MICOS complex subunit Mic19 family. Metazoan Mic25 subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length239
- Mass (Da)27,540
- Last updated2004-10-25 v1
- ChecksumA215A00FAD26DBEA
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8M6Z3Q6 | A0A8M6Z3Q6_DANRE | chchd6a | 247 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 34-75 | Polar residues | ||||
Sequence: LQRMRNTNADPRPPANNKENQGHQTRTPSTSDAQAPKTQAKT |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AL954678 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC082793 EMBL· GenBank· DDBJ | AAH82793.1 EMBL· GenBank· DDBJ | mRNA |