Q63ZW2 · MC25A_DANRE

Function

function

Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular ComponentMICOS complex
Cellular Componentmitochondrial inner membrane
Cellular Componentmitochondrion
Biological Processcristae formation
Biological ProcessDNA damage response
Biological Processinner mitochondrial membrane organization

Names & Taxonomy

Protein names

  • Recommended name
    MICOS complex subunit mic25a
  • Alternative names
    • Coiled-coil-helix-coiled-coil-helix domain-containing protein 6

Gene names

    • Name
      chchd6a
    • Synonyms
      mic25a
    • ORF names
      zgc:91802

Organism names

  • Taxonomic identifier
  • Strain
    • Tuebingen
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio

Accessions

  • Primary accession
    Q63ZW2

Proteomes

Organism-specific databases

Subcellular Location

PTM/Processing

Features

Showing features for initiator methionine, lipidation, chain, disulfide bond.

TypeIDPosition(s)Description
Initiator methionine1Removed
Lipidation2N-myristoyl glycine
ChainPRO_00004169102-239MICOS complex subunit mic25a
Disulfide bond195↔226
Disulfide bond205↔216

Keywords

Proteomic databases

Expression

Gene expression databases

Interaction

Subunit

Component of the mitochondrial contact site and cristae organizing system (MICOS) complex (also known as MINOS or MitOS complex).

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, compositional bias, coiled coil, domain, motif.

TypeIDPosition(s)Description
Region27-88Disordered
Compositional bias34-75Polar residues
Coiled coil79-166
Region113-133Disordered
Domain192-234CHCH
Motif195-205Cx9C motif 1
Motif216-226Cx9C motif 2

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    239
  • Mass (Da)
    27,540
  • Last updated
    2004-10-25 v1
  • Checksum
    A215A00FAD26DBEA
MGSGESTTRRVSFGLDEDDRVRILRGVKLSEDVLQRMRNTNADPRPPANNKENQGHQTRTPSTSDAQAPKTQAKTTFPDSKEELKKRYEQQQAIIQEELARIARKEREAARQDISRAVQRERAQTRQESERAKQLGKQLDKKEAELKALEAFYQEQITQLEKKNEERFRMSAEQFHAAATRSEANIKARNVEPVCLNLQAQILNCYRENREQTLQCSDLAKEYMQCINAAKKNLLVNHG

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8M6Z3Q6A0A8M6Z3Q6_DANREchchd6a247

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias34-75Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AL954678
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC082793
EMBL· GenBank· DDBJ
AAH82793.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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