Q63737 · PHLP_RAT
- ProteinPhosducin-like protein
- GenePdcl
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids301 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Functions as a co-chaperone for CCT in the assembly of heterotrimeric G protein complexes, facilitates the assembly of both Gbeta-Ggamma and RGS-Gbeta5 heterodimers. Acts also as a positive regulator of hedgehog signaling and regulates ciliary function.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cilium | |
Cellular Component | cytoplasm | |
Molecular Function | protein-containing complex binding | |
Biological Process | cell projection organization | |
Biological Process | heterotrimeric G-protein complex assembly | |
Biological Process | negative regulation of protein refolding | |
Biological Process | positive regulation of smoothened signaling pathway | |
Biological Process | protein folding | |
Biological Process | regulation of G protein-coupled receptor signaling pathway | |
Biological Process | visual perception |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhosducin-like protein
- Short namesPHLP
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionQ63737
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for initiator methionine, modified residue, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Initiator methionine | 1 | Removed | ||||
Sequence: M | ||||||
Modified residue | 2 | N-acetylthreonine | ||||
Sequence: T | ||||||
Chain | PRO_0000163757 | 2-301 | Phosducin-like protein | |||
Sequence: TTLDDKLLGEKLQYYYSTSEDEDSDHEDKDRGRGAPASSSTPAEAELAGEGISVNTGPKGVINDWRRFKQLETEQREEQCREMERLIKKLSMSCRSHLDEEEEQQKQKDLQEKISGKMTLKECGMMDKNLDDEEFLQQYRKQRMDEMRQQLHKGPQFKQVLEIPSGEGFLDMIDKEQKSTLIMVHIYEDGVPGTEAMNGCMICLAAEYPTVKFCRVRSSVIGASSRFTRNALPALLIYKAGELIGNFVRVTDQLGEDFFAVDLEAFLQEFGLLPEKEVLVLTSVRNSATCHSEDSDLEID | ||||||
Modified residue | 20 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 25 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 226 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 293 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 296 | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 15-60 | Disordered | ||||
Sequence: YYYSTSEDEDSDHEDKDRGRGAPASSSTPAEAELAGEGISVNTGPK | ||||||
Compositional bias | 17-35 | Basic and acidic residues | ||||
Sequence: YSTSEDEDSDHEDKDRGRG | ||||||
Region | 158-301 | Thioredoxin fold | ||||
Sequence: FKQVLEIPSGEGFLDMIDKEQKSTLIMVHIYEDGVPGTEAMNGCMICLAAEYPTVKFCRVRSSVIGASSRFTRNALPALLIYKAGELIGNFVRVTDQLGEDFFAVDLEAFLQEFGLLPEKEVLVLTSVRNSATCHSEDSDLEID |
Sequence similarities
Belongs to the phosducin family.
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing. Additional isoforms seem to exist.
Q63737-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- NameLong
- Length301
- Mass (Da)34,274
- Last updated1996-11-01 v1
- ChecksumF32C776373354AD8
Q63737-2
- NameShort
- Differences from canonical
- 1-83: Missing
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8I6A6H0 | A0A8I6A6H0_RAT | Pdcl | 286 |
Features
Showing features for alternative sequence, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_004704 | 1-83 | in isoform Short | |||
Sequence: Missing | ||||||
Compositional bias | 17-35 | Basic and acidic residues | ||||
Sequence: YSTSEDEDSDHEDKDRGRG |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
L15354 EMBL· GenBank· DDBJ | AAB00333.1 EMBL· GenBank· DDBJ | mRNA | ||
L15355 EMBL· GenBank· DDBJ | AAB00334.1 EMBL· GenBank· DDBJ | mRNA | ||
AF080435 EMBL· GenBank· DDBJ | AAC77925.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF080433 EMBL· GenBank· DDBJ | AAC77925.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF080434 EMBL· GenBank· DDBJ | AAC77925.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC097322 EMBL· GenBank· DDBJ | AAH97322.1 EMBL· GenBank· DDBJ | mRNA |