Q636K1 · Q636K1_BACCZ
- ProteinUridylate kinase
- GenesmbA
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids240 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the reversible phosphorylation of UMP to UDP.
Catalytic activity
- UMP + ATP = UDP + ADP
Activity regulation
Allosterically activated by GTP. Inhibited by UTP.
Pathway
Pyrimidine metabolism; CTP biosynthesis via de novo pathway; UDP from UMP (UMPK route): step 1/1.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 12-15 | ATP (UniProtKB | ChEBI) | ||||
Sequence: KLSG | ||||||
Binding site | 54 | UMP (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 55 | ATP (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 59 | ATP (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 74 | UMP (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 135-142 | UMP (UniProtKB | ChEBI) | ||||
Sequence: TGNPYFST | ||||||
Binding site | 163 | ATP (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 169 | ATP (UniProtKB | ChEBI) | ||||
Sequence: Y | ||||||
Binding site | 172 | ATP (UniProtKB | ChEBI) | ||||
Sequence: D |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | ATP binding | |
Molecular Function | UMP kinase activity | |
Biological Process | 'de novo' CTP biosynthetic process | |
Biological Process | phosphorylation | |
Biological Process | UDP biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameUridylate kinase
- EC number
- Short namesUK
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Bacillota > Bacilli > Bacillales > Bacillaceae > Bacillus > Bacillus cereus group
Accessions
- Primary accessionQ636K1
Proteomes
Subcellular Location
Interaction
Subunit
Homohexamer.
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 7-217 | Aspartate/glutamate/uridylate kinase | ||||
Sequence: NRVVLKLSGEALAGEQGFGINPAVIKSVAEQVKEIAELDVEVAVVVGGGNIWRGKIGSEMGMDRAGADYMGMLATVMNSLALQDSLENIGIQTRVQTSIEMRQVAEPYIRRKAVRHLEKKRVVIFAAGTGNPYFSTDTTAALRAAEIEADVILMAKNNVDGVYNADPSIDPTATKYETLTYLDVLKEGLGVMDSTASSLCMDNDIPLIVFS | ||||||
Region | 20-25 | Involved in allosteric activation by GTP | ||||
Sequence: GEQGFG |
Sequence similarities
Belongs to the UMP kinase family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length240
- Mass (Da)25,870
- Last updated2004-10-25 v1
- Checksum38F617B1244D4B9D
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000001 EMBL· GenBank· DDBJ | AAU16682.1 EMBL· GenBank· DDBJ | Genomic DNA |