Q63376 · NRX2B_RAT
- ProteinNeurexin-2-beta
- GeneNrxn2
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids662 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Features
Showing features for binding site.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Keywords
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameNeurexin-2-beta
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionQ63376
Proteomes
Organism-specific databases
Subcellular Location
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 47-586 | Extracellular | ||||
Sequence: ARVSSSLSTTHHVHHFHSKHGTVPIAINRMPFLTRSGHAGTTYIFGKGGALITYTWPPNDRPSTRMDRLAVGFSTHQRSAVLVRVDSASGLGDYLQLHIDQGTVGVIFNVGTDDITIDEPNAIVSDGKYHVVRFTRSGGNATLQVDSWPVNERYPAGNFDNERLAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQAAIKIGGRDQGRPFQGQVSGLYYNGLKVLALAAESDPNVRTEGHLRLVGEGPSVLLSAETTATTLLADMATTIMETTTTMATTTTRRGRSPTMRDSTTQNTDDLLVASAECPSDDEDLEECEPSTGGELILPIITEDSLDPPPVATRSPFVPPPPTFYPFLTGVGATQDTLPPPAARRPSSGGPCQAERDDSDCEEPVEASGFASGEVFDSSLPPTDDEDFYTTFPLVTDRTTLLSPRKPAPRPNLRTDGATGAPGVLLAPSAPAPNLPAGKMNHRDPLQPLLENPPLGPGVPTAFEPRRPPPLRPGVTSVPGFPRLPTANPTGPGERGPPGAVEVIRESSSTT | ||||||
Transmembrane | 587-607 | Helical | ||||
Sequence: GMVVGIVAAAALCILILLYAM | ||||||
Topological domain | 608-662 | Cytoplasmic | ||||
Sequence: YKYRNRDEGSYQVDQSRNYISNSAQSNGAVVKEKAPAAPKTPSKAKKNKDKEYYV |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-46 | |||||
Sequence: MPPGGSGQGGCPRRPPALAGPLPPPPPPPPLPLLLGLLLLLGAAEG | ||||||
Chain | PRO_0000019498 | 47-662 | Neurexin-2-beta | |||
Sequence: ARVSSSLSTTHHVHHFHSKHGTVPIAINRMPFLTRSGHAGTTYIFGKGGALITYTWPPNDRPSTRMDRLAVGFSTHQRSAVLVRVDSASGLGDYLQLHIDQGTVGVIFNVGTDDITIDEPNAIVSDGKYHVVRFTRSGGNATLQVDSWPVNERYPAGNFDNERLAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQAAIKIGGRDQGRPFQGQVSGLYYNGLKVLALAAESDPNVRTEGHLRLVGEGPSVLLSAETTATTLLADMATTIMETTTTMATTTTRRGRSPTMRDSTTQNTDDLLVASAECPSDDEDLEECEPSTGGELILPIITEDSLDPPPVATRSPFVPPPPTFYPFLTGVGATQDTLPPPAARRPSSGGPCQAERDDSDCEEPVEASGFASGEVFDSSLPPTDDEDFYTTFPLVTDRTTLLSPRKPAPRPNLRTDGATGAPGVLLAPSAPAPNLPAGKMNHRDPLQPLLENPPLGPGVPTAFEPRRPPPLRPGVTSVPGFPRLPTANPTGPGERGPPGAVEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQVDQSRNYISNSAQSNGAVVKEKAPAAPKTPSKAKKNKDKEYYV | ||||||
Glycosylation | 186 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 350 | O-linked (Xyl...) (heparan sulfate) serine | ||||
Sequence: S |
Post-translational modification
Keywords
- PTM
PTM databases
Expression
Interaction
Subunit
Isoform Beta 4b binds alpha-dystroglycan and neuroligins NLGN1, NLGN2 and NLGN3 (PubMed:8576240).
Interacts with CBLN1, CBLN2 and, less avidly, with CBLN4 (By similarity).
Interacts with CLSTN3 (By similarity).
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, domain, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-27 | Disordered | ||||
Sequence: MPPGGSGQGGCPRRPPALAGPLPPPPP | ||||||
Domain | 87-295 | Laminin G-like | ||||
Sequence: TTYIFGKGGALITYTWPPNDRPSTRMDRLAVGFSTHQRSAVLVRVDSASGLGDYLQLHIDQGTVGVIFNVGTDDITIDEPNAIVSDGKYHVVRFTRSGGNATLQVDSWPVNERYPAGNFDNERLAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQAAIKIGGRDQGRPFQGQVSGLYYNGLKVLALAAESDPNVRTEGHLRLVGEGPS | ||||||
Region | 408-458 | Disordered | ||||
Sequence: ATQDTLPPPAARRPSSGGPCQAERDDSDCEEPVEASGFASGEVFDSSLPPT | ||||||
Region | 476-496 | Disordered | ||||
Sequence: LLSPRKPAPRPNLRTDGATGA | ||||||
Compositional bias | 530-551 | Pro residues | ||||
Sequence: LGPGVPTAFEPRRPPPLRPGVT | ||||||
Region | 530-557 | Disordered | ||||
Sequence: LGPGVPTAFEPRRPPPLRPGVTSVPGFP | ||||||
Region | 629-662 | Disordered | ||||
Sequence: NSAQSNGAVVKEKAPAAPKTPSKAKKNKDKEYYV | ||||||
Compositional bias | 646-662 | Basic and acidic residues | ||||
Sequence: PKTPSKAKKNKDKEYYV |
Sequence similarities
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
This entry describes 18 isoforms produced by Alternative promoter usage & Alternative splicing. Two isoform types, alpha-type and beta-type are produced by alternative promoter usage. In addition there are at least five major alternatively spliced sites, each of which may be spliced in up to three different ways. Additional isoforms may derive from a minor cytoplasmic splice site 6. Combinatorial splicing at each of these six sites may lead to the generation of at least 216 isoforms but for simplicity only individual splice events are explicitly described below. Beta-type isoforms share the possibility of alternative splicing at sites 4, 5 and 6. Experimental confirmation may be lacking for some isoforms.
Q63376-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1b
- SynonymsBeta-4A5A
- Length662
- Mass (Da)70,547
- Last updated1996-11-01 v1
- ChecksumA362EFF185F2B56E
Q63376-2
- Name2b
- SynonymsBeta-4A5B
- Differences from canonical
- 368-385: Missing
Q63376-3
- Name3b
- SynonymsBeta-4B5A
- Differences from canonical
- 203-232: Missing
Q63376-4
- Name4b
- SynonymsBeta-4B5B
Q63376-5
- Name5b
- SynonymsBeta-4A5A6
- Differences from canonical
- 614-662: DEGSYQVDQSRNYISNSAQSNGAVVKEKAPAAPKTPSKAKKNKDKEYYV → CRKSPREEKLLPGSAQGLGLDLAKACCVCRCRATCIAGKPLEERGGGRGEGERQMQIYIKNK
Q63376-6
- Name6b
- SynonymsBeta-4A5B6
Q63376-7
- Name7b
- SynonymsBeta-4B5A6
Q63376-8
- Name8b
- SynonymsBeta-4B5B6
Q63374-1
The sequence of this isoform can be found in the external entry linked below. Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
View isoform- Name1a
- SynonymsAlpha-1A2A3A4A5A
Q63374-2
The sequence of this isoform can be found in the external entry linked below. Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
View isoform- Name2a
- SynonymsAlpha-1B
Q63374-3
The sequence of this isoform can be found in the external entry linked below. Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
View isoform- Name3a
- SynonymsAlpha-1C
Q63374-4
The sequence of this isoform can be found in the external entry linked below. Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
View isoform- Name4a
- SynonymsAlpha-2B
Q63374-5
The sequence of this isoform can be found in the external entry linked below. Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
View isoform- Name5a
- SynonymsAlpha-2C
Q63374-6
The sequence of this isoform can be found in the external entry linked below. Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
View isoform- Name6a
- SynonymsAlpha-3B
Q63374-7
The sequence of this isoform can be found in the external entry linked below. Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
View isoform- Name7a
- SynonymsAlpha-3C
Q63374-8
The sequence of this isoform can be found in the external entry linked below. Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
View isoform- Name8a
- SynonymsAlpha-4B
Q63374-9
The sequence of this isoform can be found in the external entry linked below. Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
View isoform- Name9a
- SynonymsAlpha-5B
Q63374-10
The sequence of this isoform can be found in the external entry linked below. Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
View isoform- Name10a
- SynonymsAlpha-6
Computationally mapped potential isoform sequences
There are 7 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q63374 | NRX2A_RAT | Nrxn2 | 1715 | ||
D3ZTM0 | D3ZTM0_RAT | Nrxn2 | 1642 | ||
A0A8I6GML4 | A0A8I6GML4_RAT | Nrxn2 | 1665 | ||
D3ZAD6 | D3ZAD6_RAT | Nrxn2 | 1695 | ||
A0A8I5ZY56 | A0A8I5ZY56_RAT | Nrxn2 | 1503 | ||
A0A8I6GD15 | A0A8I6GD15_RAT | Nrxn2 | 1708 | ||
A0A8I5ZSS5 | A0A8I5ZSS5_RAT | Nrxn2 | 50 |
Features
Showing features for alternative sequence, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_003518 | 203-232 | in isoform 3b, isoform 4b, isoform 7b and isoform 8b | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_003519 | 368-385 | in isoform 2b, isoform 4b, isoform 6b and isoform 8b | |||
Sequence: Missing | ||||||
Compositional bias | 530-551 | Pro residues | ||||
Sequence: LGPGVPTAFEPRRPPPLRPGVT | ||||||
Alternative sequence | VSP_003520 | 614-662 | in isoform 5b, isoform 6b, isoform 7b and isoform 8b | |||
Sequence: DEGSYQVDQSRNYISNSAQSNGAVVKEKAPAAPKTPSKAKKNKDKEYYV → CRKSPREEKLLPGSAQGLGLDLAKACCVCRCRATCIAGKPLEERGGGRGEGERQMQIYIKNK | ||||||
Compositional bias | 646-662 | Basic and acidic residues | ||||
Sequence: PKTPSKAKKNKDKEYYV |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
M96377 EMBL· GenBank· DDBJ | AAA41708.1 EMBL· GenBank· DDBJ | mRNA |