Q63148 · CHRD_RAT

Function

function

Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes (By similarity).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcell surface
Cellular Componentextracellular region
Cellular Componentextracellular space
Cellular Componentpresynapse
Molecular FunctionBMP binding
Molecular Functionheparan sulfate proteoglycan binding
Molecular Functionheparin binding
Molecular Functionsyndecan binding
Biological Processartery morphogenesis
Biological ProcessBMP signaling pathway
Biological Processcell population proliferation
Biological Processcentral nervous system development
Biological Processchordate pharynx development
Biological Processcranial skeletal system development
Biological Processdescending aorta development
Biological Processdorsal/ventral pattern formation
Biological Processembryonic axis specification
Biological Processembryonic heart tube development
Biological Processepithelial cell fate commitment
Biological Processexploration behavior
Biological Processfibroblast growth factor receptor signaling pathway
Biological Processforebrain development
Biological Processgastrulation with mouth forming second
Biological Processgene expression
Biological Processin utero embryonic development
Biological Processlong-term synaptic potentiation
Biological Processmaintenance of protein location
Biological Processmesenchymal cell fate commitment
Biological Processmesoderm formation
Biological Processnegative regulation of BMP signaling pathway
Biological Processnegative regulation of cell migration
Biological Processnegative regulation of osteoblast differentiation
Biological Processneural crest formation
Biological Processneuron fate commitment
Biological Processosteoblast differentiation
Biological Processpattern specification process
Biological Processpositive regulation of cell adhesion
Biological Processpositive regulation of mesenchymal cell proliferation
Biological Processpresynaptic modulation of chemical synaptic transmission
Biological Processprotein import
Biological Processregulation of neuronal synaptic plasticity
Biological Processshort-term synaptic potentiation
Biological Processskeletal system development
Biological Processsmoothened signaling pathway
Biological Processspinal cord dorsal/ventral patterning
Biological Processsynapse organization
Biological Processvenous blood vessel morphogenesis
Biological Processvisual learning

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Chordin

Gene names

    • Name
      Chrd

Organism names

  • Taxonomic identifier
  • Strains
    • Brown Norway
    • Sprague-Dawley
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    Q63148

Proteomes

Organism-specific databases

Subcellular Location

PTM/Processing

Features

Showing features for signal, chain, glycosylation.

Type
IDPosition(s)Description
Signal1-26
ChainPRO_000021908827-951Chordin
Glycosylation350N-linked (GlcNAc...) asparagine
Glycosylation433N-linked (GlcNAc...) asparagine
Glycosylation880N-linked (GlcNAc...) asparagine

Post-translational modification

Cleaved by tolloid proteases; cleavage participates in dorsoventral patterning during early development.

Keywords

Proteomic databases

PTM databases

Interaction

Subunit

Interacts with TWSG1 and/or BMP4.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain49-126VWFC 1
Region144-170Disordered
Compositional bias145-170Basic and acidic residues
Domain171-280CHRD 1
Domain282-401CHRD 2
Domain402-523CHRD 3
Domain529-649CHRD 4
Region669-701Disordered
Domain702-762VWFC 2
Domain782-848VWFC 3
Domain870-930VWFC 4
Region932-951Disordered

Sequence similarities

Belongs to the chordin family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    951
  • Mass (Da)
    102,007
  • Last updated
    2007-03-20 v2
  • Checksum
    F7E2F509718C0EBE
MPSLPAPPAPRLLLGLLLLGSRPAGGTGPEAPALPIRSEKEPLPVRGAAGCSFGGKVYALDETWHPDLGEPFGVMRCVLCACEAPQWARRGRGPGRVSCKNIKPQCPTLACRQPRQLPGHCCQTCPQDAERSNLDPQPAGLVFEYPRDPEHRSYSDRGEPGTGERTRGDGHTEDFVALLTGPRTQAVARARVSLLRSSLRFSISYQRLDRPSRVRFTDPTGNILFEHPAAPTQDGLVCGVWRAVPRLSVRLLRAEQLRVALVTPTHPSEEVWGPLIWQGALTAETFSAILTLEDPLQRGVGGIALLTLSDTEDALHFLLLFRGLLGGLAHVPLKLQILHQGQLLRELQANASAQEPGFAEVLPSLTDQEMDWLVLGELQMVLEKMGGPELRISGYITTRQSCDVLQSVLCGADALIPVQTGAAGSASFILLGNGSLIYQVQVIGTGSEVVAMTLETKPQRKNQRTVLCHMAGLQLGGHMAVGVCSGLGARGAHMLLQNELFLNIGTKDFPDGELRGHVTALCYSGHSAHYDRLPVPLAGALVLPPVRSQAAGHAWLSLDTHCHLHYEVLLAGLGGSEQGTVTAHLLGPPGMPGPQRLLKGFYGSEAQGVVKDLEPVLLRHLTQGTASLLITTKSNPRGELRGQVHIASQCEVGGLRLASEGVRMSLAPNGEAATSPMLPAGPGPEAPVPAKHGSSGRPRDPNTCFFEGQQRPHGARWAPNYDPLCSLCTCQRRTVICDPVVCPPPSCPHPVQALDQCCPVCPEKQRSRDLPSLPNLEPGEGCYFDGDRSWRAAGTRWHPVVPPFGLIKCAVCTCKGATGEVHCEKVQCPRLACAQPVRANPTDCCKQCPVGSGTHAKLGDPMQADGPRGCRFAGQWFPENQSWHPSVPPFGEMSCITCRCGAGVPHCERDDCSPPLSCGSGKESRCCSHCTAQRSSETRTLPELEKEAQRS

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A140TA94A0A140TA94_RATChrd970

Features

Showing features for compositional bias, sequence conflict.

Type
IDPosition(s)Description
Compositional bias145-170Basic and acidic residues
Sequence conflict746-749in Ref. 2; BAA13128
Sequence conflict757in Ref. 2; BAA13128
Sequence conflict762in Ref. 2; BAA13128
Sequence conflict771in Ref. 2; BAA13128
Sequence conflict810in Ref. 2; BAA13128
Sequence conflict817-818in Ref. 2; BAA13128
Sequence conflict823in Ref. 2; BAA13128

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AABR03079283
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
D86581
EMBL· GenBank· DDBJ
BAA13128.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

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