Q62CH7 · BETB_BURMA

Function

function

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the irreversible oxidation of betaine aldehyde to the corresponding acid.

Catalytic activity

Cofactor

K+ (UniProtKB | Rhea| CHEBI:29103 )

Note: Binds 2 potassium ions per subunit.

Pathway

Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1.

Features

Showing features for binding site, active site, site.

TypeIDPosition(s)Description
Binding site26K+ 1 (UniProtKB | ChEBI)
Binding site93K+ 1 (UniProtKB | ChEBI)
Binding site150-152NAD+ (UniProtKB | ChEBI)
Active site162Charge relay system
Binding site176-179NAD+ (UniProtKB | ChEBI)
Binding site180K+ 1 (UniProtKB | ChEBI)
Binding site229-232NAD+ (UniProtKB | ChEBI)
Binding site245K+ 2 (UniProtKB | ChEBI)
Site247Seems to be a necessary countercharge to the potassium cations
Active site251Proton acceptor
Binding site253NAD+ (UniProtKB | ChEBI)
Active site285Nucleophile
Binding site285NAD+ (UniProtKB | ChEBI); covalent
Binding site386NAD+ (UniProtKB | ChEBI)
Binding site456K+ 2 (UniProtKB | ChEBI)
Binding site459K+ 2 (UniProtKB | ChEBI)
Active site463Charge relay system

GO annotations

AspectTerm
Molecular Functionbetaine-aldehyde dehydrogenase (NAD+) activity
Molecular Functionmetal ion binding
Biological Processglycine betaine biosynthetic process from choline

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Betaine aldehyde dehydrogenase
  • EC number
  • Short names
    BADH

Gene names

    • Name
      betB
    • Ordered locus names
      BMAA0915

Organism names

Accessions

  • Primary accession
    Q62CH7

Proteomes

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00000565391-489Betaine aldehyde dehydrogenase
Modified residue285Cysteine sulfenic acid (-SOH)

Keywords

Interaction

Subunit

Dimer of dimers.

Structure

Family & Domains

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    489
  • Mass (Da)
    52,173
  • Last updated
    2004-10-25 v1
  • Checksum
    53E483722690674A
MSVYGLQRLYIAGAHADATSGKTFDTFDPATGELLARVQQASADDVDRAVASAREGQREWAAMTAMQRSRILRRAVELLRERNDALAELEMRDTGKPIAETRAVDIVTGADVIEYYAGLATAIEGLQVPLRPESFVYTRREPLGVCAGIGAWNYPIQIACWKSAPALAAGNAMIFKPSEVTPLSALKLAEIYTEAGVPAGVFNVVQGDGSVGALLSAHPGIAKVSFTGGVETGKKVMSLAGASSLKEVTMELGGKSPLIVFDDADLDRAADIAVTANFFSAGQVCTNGTRVFVQQAVKDAFVERVLARVARIRAGKPSDPDTNFGPLASAAQLDKVLGYIDSGKAEGAKLLAGGARLVNDHFASGQYVAPTVFGDCRDDMRIVREEIFGPVMSILSFETEDEAIARANATDYGLAAGVVTENLSRAHRAIHRLEAGICWINTWGESPAEMPVGGYKQSGVGRENGITTLEHYTRIKSVQVELGRYQPVF

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000011
EMBL· GenBank· DDBJ
AAU46695.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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