Q62889 · NLGN3_RAT

Function

function

Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. May also play a role in glia-glia or glia-neuron interactions in the developing peripheral nervous system.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcell surface
Cellular Componentdendrite
Cellular Componentendocytic vesicle
Cellular Componentexcitatory synapse
Cellular ComponentGABA-ergic synapse
Cellular Componentglutamatergic synapse
Cellular Componentinhibitory synapse
Cellular Componentneuronal cell body
Cellular Componentplasma membrane
Cellular Componentpostsynaptic membrane
Cellular Componentpostsynaptic specialization membrane
Cellular Componentpresynapse
Cellular Componentsynapse
Molecular Functioncell adhesion molecule binding
Molecular Functionneurexin family protein binding
Molecular Functionscaffold protein binding
Molecular Functionsignaling receptor activity
Biological Processadult behavior
Biological Processaxon extension
Biological Processchemical synaptic transmission
Biological Processcircadian sleep/wake cycle
Biological Processexcitatory postsynaptic potential
Biological Processinhibitory postsynaptic potential
Biological Processlearning
Biological Processlong-term synaptic potentiation
Biological Processmodulation of chemical synaptic transmission
Biological Processnegative regulation of dendritic spine morphogenesis
Biological Processnegative regulation of excitatory postsynaptic potential
Biological Processneuron cell-cell adhesion
Biological Processoligodendrocyte differentiation
Biological Processpositive regulation of dendritic spine development
Biological Processpositive regulation of excitatory postsynaptic potential
Biological Processpositive regulation of glutamate receptor signaling pathway
Biological Processpositive regulation of inhibitory postsynaptic potential
Biological Processpositive regulation of protein localization to synapse
Biological Processpositive regulation of synapse assembly
Biological Processpositive regulation of synaptic transmission, glutamatergic
Biological Processpositive regulation of synaptic vesicle clustering
Biological Processpostsynaptic membrane assembly
Biological Processpostsynaptic specialization assembly
Biological Processprepulse inhibition
Biological Processpresynaptic membrane assembly
Biological Processreceptor-mediated endocytosis
Biological Processregulation of AMPA receptor activity
Biological Processregulation of dendritic spine morphogenesis
Biological Processregulation of long-term synaptic potentiation
Biological Processregulation of NMDA receptor activity
Biological Processregulation of respiratory gaseous exchange by nervous system process
Biological Processregulation of synaptic transmission, glutamatergic
Biological Processregulation of terminal button organization
Biological Processrhythmic synaptic transmission
Biological Processsocial behavior
Biological Processsynapse assembly
Biological Processsynapse organization
Biological Processsynaptic vesicle endocytosis
Biological Processvisual learning
Biological Processvocalization behavior

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Neuroligin-3
  • Alternative names
    • Gliotactin homolog

Gene names

    • Name
      Nlgn3

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    Q62889

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain38-709Extracellular
Transmembrane710-730Helical
Topological domain731-848Cytoplasmic

Keywords

Phenotypes & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis451Impaired cell surface expression, and reduced interaction with NRXN1.

PTM/Processing

Features

Showing features for signal, chain, glycosylation, disulfide bond, modified residue.

TypeIDPosition(s)Description
Signal1-37
ChainPRO_000000864738-848Neuroligin-3
Glycosylation98N-linked (GlcNAc...) asparagine
Disulfide bond106↔141
Disulfide bond340↔351
Disulfide bond510↔544
Glycosylation545N-linked (GlcNAc...) asparagine
Modified residue745Phosphoserine
Modified residue792Phosphotyrosine

Post-translational modification

The N-terminus is blocked.

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Detected in brain and on hippocampus neurons, especially at excitatory synapses. Detected in retina (at protein level). Expressed in brain, spinal cord and dorsal root ganglion.

Interaction

Subunit

Homodimer, and heterodimer with NLGN1 and NLGN2 (By similarity).
Interacts with neurexins NRXN1, NRXN2 and NRXN3 (PubMed:15152050, PubMed:20624592, PubMed:8576240).
Interaction with neurexins is mediated by heparan sulfate glycan modification on neurexin (By similarity).
Interacts (via its C-terminus) with DLG4/PSD-95 (via PDZ domain 3) (By similarity).

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region169-195Disordered
Compositional bias645-687Polar residues
Region645-691Disordered

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (4)
  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.

This entry describes 4 isoforms produced by Alternative splicing.

Q62889-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    848
  • Mass (Da)
    93,888
  • Last updated
    1996-11-01 v1
  • Checksum
    7520653B3253E750
MWLQLGLPSLSLSPTPTVGRSLCLILWFLSLVLRASTQAPAPTVNTHFGKLRGARVPLPSEILGPVDQYLGVPYAAPPIGEKRFLPPEPPPSWSGIRNATHFPPVCPQNIHTAVPEVMLPVWFTANLDIVATYIQEPNEDCLYLNVYVPTEDVKRISKECARKPNKKICRKGGSGAKKQGEDLADNDGDEDEDIRDSGAKPVMVYIHGGSYMEGTGNMIDGSVLASYGNVIVITLNYRVGVLGFLSTGDQAAKGNYGLLDQIQALRWVSENIAFFGGDPRRITVFGSGIGASCVSLLTLSHHSEGLFQRAIIQSGSALSSWAVNYQPVKYTSLLADKVGCNVLDTVDMVDCLRQKSAKELVEQDIQPARYHVAFGPVIDGDVIPDDPEILMEQGEFLNYDIMLGVNQGEGLKFVEGVVDPEDGVSGTDFDYSVSNFVDNLYGYPEGKDTLRETIKFMYTDWADRDNPETRRKTLVALFTDHQWVEPSVVTADLHARYGSPTYFYAFYHHCQSLMKPAWSDAAHGDEVPYVFGVPMVGPTDLFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNKPVPQDTKFIHTKANRFEEVAWSKYNPRDQLYLHIGLKPRVRDHYRATKVAFWKHLVPHLYNLHDMFHYTSTTTKVPPPDTTHSSHITRRPNGKTWSTKRPAISPAYSNENAPGSWNGDQDAGPLLVENPRDYSTELSVTIAVGASLLFLNVLAFAALYYRKDKRRQEPLRQPSPQRGTGAPELGTAPEEELAALQLGPTHHECEAGPPHDTLRLTALPDYTLTLRRSPDDIPLMTPNTITMIPNSLVGLQTLHPYNTFAAGFNSTGLPNSHSTTRV

Q62889-2

Q62889-3

  • Name
    3
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Q62889-4

  • Name
    4
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There are 4 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
F1LPZ8F1LPZ8_RATNlgn3848
D3ZDC0D3ZDC0_RATNlgn3828
A0A096MK63A0A096MK63_RATNlgn3808
A0A8I5ZNW2A0A8I5ZNW2_RATNlgn3828

Features

Showing features for alternative sequence, compositional bias.

TypeIDPosition(s)Description
Alternative sequenceVSP_007535153-172in isoform 2 and isoform 4
Alternative sequenceVSP_007536173-192in isoform 2 and isoform 3
Compositional bias645-687Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U41663
EMBL· GenBank· DDBJ
AAA97871.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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