Q62683 · Q62683_RAT
- ProteinGlutamate receptor
- GeneGrin1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids938 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.
Features
Showing features for binding site, site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 516 | L-glutamate (UniProtKB | ChEBI) | |||
Binding site | 518 | L-glutamate (UniProtKB | ChEBI) | |||
Binding site | 523 | L-glutamate (UniProtKB | ChEBI) | |||
Site | 664 | Crucial to convey clamshell closure to channel opening | |||
Binding site | 688 | L-glutamate (UniProtKB | ChEBI) | |||
Site | 694 | Interaction with the cone snail toxin Con-ikot-ikot | |||
Binding site | 732 | L-glutamate (UniProtKB | ChEBI) | |||
Site | 778 | Interaction with the cone snail toxin Con-ikot-ikot | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | NMDA selective glutamate receptor complex | |
Cellular Component | postsynaptic membrane | |
Cellular Component | synapse | |
Molecular Function | glycine binding | |
Molecular Function | ligand-gated monoatomic ion channel activity | |
Molecular Function | signaling receptor activity | |
Biological Process | excitatory postsynaptic potential | |
Biological Process | ionotropic glutamate receptor signaling pathway | |
Biological Process | learning or memory | |
Biological Process | monoatomic cation transmembrane transport |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameGlutamate receptor
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionQ62683
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 562-580 | Helical | |||
Transmembrane | 635-657 | Helical | |||
Transmembrane | 813-837 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, disulfide bond.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-20 | ||||
Chain | PRO_5027166046 | 21-938 | Glutamate receptor | ||
Disulfide bond | 744↔798 | ||||
Keywords
- PTM
Interaction
Chemistry
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 433-795 | Ionotropic glutamate receptor C-terminal | |||
Domain | 444-507 | Ionotropic glutamate receptor L-glutamate and glycine-binding | |||
Region | 889-938 | Disordered | |||
Compositional bias | 917-938 | Basic and acidic residues | |||
Sequence similarities
Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR1/GRIN1 subfamily.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length938
- Mass (Da)105,569
- Last updated1996-11-01 v1
- Checksum3B279C4925AF16DE
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 917-938 | Basic and acidic residues | |||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
U11418 EMBL· GenBank· DDBJ | AAA19659.1 EMBL· GenBank· DDBJ | mRNA |