Q62683 · Q62683_RAT

  • Protein
    Glutamate receptor
  • Gene
    Grin1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    4/5

Function

function

Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

Features

Showing features for binding site, site.

1938100200300400500600700800900
Type
IDPosition(s)Description
Binding site516L-glutamate (UniProtKB | ChEBI)
Binding site518L-glutamate (UniProtKB | ChEBI)
Binding site523L-glutamate (UniProtKB | ChEBI)
Site664Crucial to convey clamshell closure to channel opening
Binding site688L-glutamate (UniProtKB | ChEBI)
Site694Interaction with the cone snail toxin Con-ikot-ikot
Binding site732L-glutamate (UniProtKB | ChEBI)
Site778Interaction with the cone snail toxin Con-ikot-ikot

GO annotations

AspectTerm
Cellular ComponentNMDA selective glutamate receptor complex
Cellular Componentpostsynaptic membrane
Cellular Componentsynapse
Molecular Functionglycine binding
Molecular Functionligand-gated monoatomic ion channel activity
Molecular Functionsignaling receptor activity
Biological Processexcitatory postsynaptic potential
Biological Processionotropic glutamate receptor signaling pathway
Biological Processlearning or memory
Biological Processmonoatomic cation transmembrane transport

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Glutamate receptor

Gene names

    • Name
      Grin1

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    Q62683

Organism-specific databases

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane562-580Helical
Transmembrane635-657Helical
Transmembrane813-837Helical

Keywords

PTM/Processing

Features

Showing features for signal, chain, disulfide bond.

Type
IDPosition(s)Description
Signal1-20
ChainPRO_502716604621-938Glutamate receptor
Disulfide bond744↔798

Keywords

Interaction

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain433-795Ionotropic glutamate receptor C-terminal
Domain444-507Ionotropic glutamate receptor L-glutamate and glycine-binding
Region889-938Disordered
Compositional bias917-938Basic and acidic residues

Sequence similarities

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    938
  • Mass (Da)
    105,569
  • Last updated
    1996-11-01 v1
  • Checksum
    3B279C4925AF16DE
MSTMHLLTFALLFSCSFARAACDPKIVNIGAVLSTRKHEQMFREAVNQANKRHGSWKIQLNATSVTHKPNAIQMALSVCEDLISSQVYAILVSHPPTPNDHFTPTPVSYTAGFYRIPVLGLTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYNWNHIILLVSDDHEGRAAQKRLETLLEERESKAEKVLQFDPGTKNVTALLMEARELEARVIILSASEDDAATVYRAAAMLNMTGSGYVWLVGEREISGNALRYAPDGIIGLQLINGKNESAHISDAVGVVAQAVHELLEKENITDPPRGCVGNTNIWKTGPLFKRVLMSSKYADGVTGRVEFNEDGDRKFANYSIMNLQNRKLVQVGIYNGTHVIPNDRKIIWPGGETEKPRGYQMSTRLKIVTIHQEPFVYVKPTMSDGTCKEEFTVNGDPVKKVICTGPNDTFPGSPRHTVPQCCYGFCIDLLIKLARTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTILVKKEIPRSTLDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPFGRFKVNSEEEEEDALTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRPEERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQVELSTMYRHMEKHNYESAAEAIQAVRDNKLHAFIWDSAVLEFEASQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSHENGFMEDLDKTWVRYQECDSRSNAPATLTFENMAGVFMLVAGGIVAGIFLIFIEIAYKRHKDARRKQMQLAFAAVNVWRKNLQDRKSGRAEPDPKKKATFRAITSTLASSFKRRRSSKDTSTGGGRGALQNQKDTVLPRRAIEREEGQLQLCSRHRES

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias917-938Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U11418
EMBL· GenBank· DDBJ
AAA19659.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

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