Q62662 · FRK_RAT

  • Protein
    Tyrosine-protein kinase FRK
  • Gene
    Frk
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

function

Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor (By similarity).

Catalytic activity

Features

Showing features for binding site, active site.

150650100150200250300350400450500
TypeIDPosition(s)Description
Binding site241-249ATP (UniProtKB | ChEBI)
Binding site263ATP (UniProtKB | ChEBI)
Active site355Proton acceptor

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleus
Cellular Componentplasma membrane
Molecular FunctionATP binding
Molecular Functionnon-membrane spanning protein tyrosine kinase activity
Molecular Functionprotein tyrosine kinase activity
Molecular Functionsignaling receptor binding
Biological Processcell differentiation
Biological Processcell surface receptor protein tyrosine kinase signaling pathway
Biological Processinnate immune response
Biological Processnegative regulation of transcription by RNA polymerase II

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Tyrosine-protein kinase FRK
  • EC number
  • Alternative names
    • FYN-related kinase
    • Gastrointestinal-associated kinase (GASK)
    • Gastrointestinal-associated tyrosine kinase (GTK)

Gene names

    • Name
      Frk
    • Synonyms
      Gask

Organism names

  • Taxonomic identifier
  • Strain
    • Sprague-Dawley
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    Q62662

Proteomes

Organism-specific databases

Subcellular Location

Cytoplasm
Nucleus
Note: Predominantly found in the nucleus, with a small fraction found in the cell periphery.

Keywords

Phenotypes & Variants

Keywords

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00002608271-506Tyrosine-protein kinase FRK
Modified residue179Phosphothreonine
Modified residue388Phosphotyrosine; by autocatalysis

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Highly expressed in stomach, small intestine and colon. Concentrated in the brush border membranes of epithelial cells, throughout the maturation axis of the adult small intestine.

Gene expression databases

Interaction

Subunit

Interacts (via the SH3-domain) with PTEN. Interacts with RB1 (By similarity).

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain43-111SH3
Domain117-209SH2
Domain235-492Protein kinase

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    506
  • Mass (Da)
    58,166
  • Last updated
    2007-01-23 v3
  • Checksum
    69F471DE4F974D82
MGSVCMRLWAYLQPFLPCWSQEADKSVVIENPGAYCPPEANRSQGQYFVALFDYEARTAEDLSFHAGDKLQVLDTSHEGWWLARHLEKKGPGLGQQLQGYIPSNYVAEDRSLQAEPWFFGAIKRADAEKQLLYSENQTGAFLIRESESQKGDFSLSVLDEGVVKHYRIRRLDEGGFFLTRRKTFSTLNEFVNYYTTTSDGLCVKLEKPCLKIQVPTPFDLSYKTVDQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIMKSLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDGGSKIRLTQQVDMAAQVASGMAYLESQNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESKHEIKLPVKWTAPEAIRTNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIHMLGQNYRLPQPSNCPEQFYSIMMECWNVEPKQRPTFETLHWKLEDYFEPDSSYSDTNNFIN

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8L2PZJ9A0A8L2PZJ9_RATFrk503

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U09583
EMBL· GenBank· DDBJ
AAC52725.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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