Q62662 · FRK_RAT
- ProteinTyrosine-protein kinase FRK
- GeneFrk
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids506 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor (By similarity).
Catalytic activity
- ATP + L-tyrosyl-[protein] = ADP + H+ + O-phospho-L-tyrosyl-[protein]
Features
Showing features for binding site, active site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | nucleus | |
Cellular Component | plasma membrane | |
Molecular Function | ATP binding | |
Molecular Function | non-membrane spanning protein tyrosine kinase activity | |
Molecular Function | protein tyrosine kinase activity | |
Molecular Function | signaling receptor binding | |
Biological Process | cell differentiation | |
Biological Process | cell surface receptor protein tyrosine kinase signaling pathway | |
Biological Process | innate immune response | |
Biological Process | negative regulation of transcription by RNA polymerase II |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameTyrosine-protein kinase FRK
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionQ62662
Proteomes
Organism-specific databases
Phenotypes & Variants
Keywords
- Disease
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000260827 | 1-506 | Tyrosine-protein kinase FRK | |||
Sequence: MGSVCMRLWAYLQPFLPCWSQEADKSVVIENPGAYCPPEANRSQGQYFVALFDYEARTAEDLSFHAGDKLQVLDTSHEGWWLARHLEKKGPGLGQQLQGYIPSNYVAEDRSLQAEPWFFGAIKRADAEKQLLYSENQTGAFLIRESESQKGDFSLSVLDEGVVKHYRIRRLDEGGFFLTRRKTFSTLNEFVNYYTTTSDGLCVKLEKPCLKIQVPTPFDLSYKTVDQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIMKSLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDGGSKIRLTQQVDMAAQVASGMAYLESQNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESKHEIKLPVKWTAPEAIRTNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIHMLGQNYRLPQPSNCPEQFYSIMMECWNVEPKQRPTFETLHWKLEDYFEPDSSYSDTNNFIN | ||||||
Modified residue | 179 | Phosphothreonine | ||||
Sequence: T | ||||||
Modified residue | 388 | Phosphotyrosine; by autocatalysis | ||||
Sequence: Y |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Highly expressed in stomach, small intestine and colon. Concentrated in the brush border membranes of epithelial cells, throughout the maturation axis of the adult small intestine.
Gene expression databases
Interaction
Subunit
Interacts (via the SH3-domain) with PTEN. Interacts with RB1 (By similarity).
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 43-111 | SH3 | ||||
Sequence: SQGQYFVALFDYEARTAEDLSFHAGDKLQVLDTSHEGWWLARHLEKKGPGLGQQLQGYIPSNYVAEDRS | ||||||
Domain | 117-209 | SH2 | ||||
Sequence: WFFGAIKRADAEKQLLYSENQTGAFLIRESESQKGDFSLSVLDEGVVKHYRIRRLDEGGFFLTRRKTFSTLNEFVNYYTTTSDGLCVKLEKPC | ||||||
Domain | 235-492 | Protein kinase | ||||
Sequence: IQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIMKSLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDGGSKIRLTQQVDMAAQVASGMAYLESQNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESKHEIKLPVKWTAPEAIRTNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIHMLGQNYRLPQPSNCPEQFYSIMMECWNVEPKQRPTFETLHWKLEDYF |
Sequence similarities
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length506
- Mass (Da)58,166
- Last updated2007-01-23 v3
- Checksum69F471DE4F974D82
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8L2PZJ9 | A0A8L2PZJ9_RAT | Frk | 503 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
U09583 EMBL· GenBank· DDBJ | AAC52725.1 EMBL· GenBank· DDBJ | mRNA |