Q62599 · MTA1_RAT

  • Protein
    Metastasis-associated protein MTA1
  • Gene
    Mta1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Transcriptional coregulator which can act as both a transcriptional corepressor and coactivator (By similarity).
Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (By similarity).
In the NuRD complex, regulates transcription of its targets by modifying the acetylation status of the target chromatin and cofactor accessibility to the target DNA (By similarity).
In conjunction with other components of NuRD, acts as a transcriptional corepressor of BRCA1, ESR1, TFF1 and CDKN1A (By similarity).
Acts as a transcriptional coactivator of BCAS3, and SUMO2, independent of the NuRD complex (By similarity).
Stimulates the expression of WNT1 by inhibiting the expression of its transcriptional corepressor SIX3 (By similarity).
Regulates p53-dependent and -independent DNA repair processes following genotoxic stress (By similarity).
Regulates the stability and function of p53/TP53 by inhibiting its ubiquitination by COP1 and MDM2 thereby regulating the p53-dependent DNA repair (By similarity).
Plays a role in the regulation of the circadian clock and is essential for the generation and maintenance of circadian rhythms under constant light and for normal entrainment of behavior to light-dark (LD) cycles (By similarity).
Positively regulates the CLOCK-BMAL1 heterodimer mediated transcriptional activation of its own transcription and the transcription of CRY1 (By similarity).
Regulates deacetylation of BMAL1 by regulating SIRT1 expression, resulting in derepressing CRY1-mediated transcription repression (By similarity).
With TFCP2L1, promotes establishment and maintenance of pluripotency in embryonic stem cells (ESCs) and inhibits endoderm differentiation (By similarity).

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentendoplasmic reticulum
Cellular ComponentGolgi apparatus
Cellular Componentmicrotubule
Cellular Componentnuclear envelope
Cellular Componentnucleoplasm
Cellular Componentnucleus
Cellular ComponentNuRD complex
Cellular Componentrough endoplasmic reticulum
Cellular Componentzymogen granule
Molecular Functionchromatin binding
Molecular Functionenzyme binding
Molecular Functionhistone deacetylase binding
Molecular Functionmetal ion binding
Molecular FunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular FunctionRNA polymerase II-specific DNA-binding transcription factor binding
Molecular Functiontranscription coactivator activity
Molecular Functiontranscription corepressor activity
Biological Processchromatin remodeling
Biological Processcircadian regulation of gene expression
Biological Processdouble-strand break repair
Biological Processentrainment of circadian clock by photoperiod
Biological Processfemale pregnancy
Biological Processlocomotor rhythm
Biological Processnegative regulation of gene expression, epigenetic
Biological Processnegative regulation of transcription by RNA polymerase II
Biological Processpositive regulation of protein autoubiquitination
Biological Processproteasome-mediated ubiquitin-dependent protein catabolic process
Biological Processresponse to ionizing radiation
Biological Processsecretory granule organization

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Metastasis-associated protein MTA1

Gene names

    • Name
      Mta1
    • Synonyms
      Zg29

Organism names

  • Taxonomic identifier
  • Strains
    • Fischer 344
    • Wistar
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    Q62599
  • Secondary accessions
    • Q9Z0N8

Proteomes

Organism-specific databases

Subcellular Location

Isoform 1

Nucleus
Nucleus envelope
Cytoplasm
Note: Associated with microtubules. Localization at the nuclear envelope is TPR-dependent (By similarity).

Isoform 2

Golgi apparatus
Zymogen granule

Keywords

PTM/Processing

Features

Showing features for chain, cross-link, modified residue.

TypeIDPosition(s)Description
ChainPRO_00000834951-703Metastasis-associated protein MTA1
Cross-link182Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
Modified residue386Phosphoserine
Modified residue449Phosphoserine
Cross-link509Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2 and SUMO3)
Modified residue522Phosphoserine
Cross-link549Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)
Modified residue564Phosphothreonine
Modified residue576Phosphoserine
Modified residue578Phosphothreonine
Modified residue614N6-acetyllysine; alternate
Cross-link614Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate
Modified residue627Phosphoserine

Post-translational modification

Phosphorylation by CSNK1G2/CK1 triggered by estrogen enhances corepression of estrogen receptor (ER).
Acetylation is essential for its transcriptional coactivator activity.
Sumoylation positively regulates its transcriptional corepressor activity but does not affect the protein stability. Sumoylated preferentially by SUMO2 or SUMO3 than SUMO1. Sumoylation is enhanced by PIAS1/3/4 and preferentially sumoylated by SUMO2 in the presence of PIAS1/3/4. Desumoylated by SENP1 (By similarity).
Ubiquitinated by COP1, which leads to proteasomal degradation.

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Isoform 1 abundant in testis and expressed at low levels in brain, heart, lung, liver, and kidney. Isoform 2 abundant in adrenal gland, brain, colon, heart, liver, lung, muscle, prostate, stomach, testis, and thymus and expressed at low levels in duodenum, kidney, pancreas, parotid, and spleen.

Induction

Isoform 1

Induced by dexamethasone and, in pancreas, by treatment with the proteinase inhibitor FOY-305 which binds to activated trypsin and induces release of cholecystokinin.

Developmental stage

Isoform 1

Highly expressed in metastatic cells.

Interaction

Subunit

Component of the nucleosome remodeling and deacetylase (NuRD) repressor complex, composed of core proteins MTA1, MTA2, MTA3, RBBP4, RBBP7, HDAC1, HDAC2, MBD2, MBD3, and peripherally associated proteins CDK2AP1, CDK2AP2, GATAD2A, GATAD2B, CHD3, CHD4 and CHD5 (By similarity).
The exact stoichiometry of the NuRD complex is unknown, and some subunits such as MBD2 and MBD3, GATAD2A and GATAD2B, and CHD3, CHD4 and CHD5 define mutually exclusive NuRD complexes (By similarity).
Interacts with RBBP4; the interaction is direct (By similarity).
Interacts with BMAL1. Interacts with CLOCK. Interacts with COP1. Interacts with CSNK1G2 in the cytoplasm. Interacts with EP300. Interacts with HDAC2 (By similarity).
Interacts with ITGB3BP/CENPR (By similarity).
Interacts with MBD3L2 (By similarity).
Interacts with MDM2 (By similarity).
Interacts with NACC2 (By similarity).
Interacts with p53/TP53. Interacts with PIAS1. Interacts with PIAS3. Interacts with PIAS4. Interacts with PWWP2A. Interacts with PWWP2B. Interacts with SENP1. Interacts with SENP2. Interacts with SIX3; facilitates the binding of SIX3 to the core DNA motif of SIX3 promoter. Interacts with SUMO1. Interacts with SUMO2. Interacts with TFCP2L1; which is indispensable for TFCP2L1-mediated self-renewal-promoting effect and endoderm-inhibiting action (By similarity).
Interacts with TFAP2C (By similarity).
Interacts with TPR. Interacts with UBE2I/UBC9 (By similarity).

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q62599Six3 Q9ET752EBI-349237, EBI-15649593

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, zinc finger, region, motif, compositional bias.

TypeIDPosition(s)Description
Domain1-164BAH
Domain165-276ELM2
Domain283-335SANT
Zinc finger393-420GATA-type; atypical
Region437-460Disordered
Region542-583Disordered
Motif545-552SH3-binding
Compositional bias554-583Polar residues
Region644-674Interaction with RBBP4
Region661-703Disordered
Motif684-693SH3-binding
Motif699-703SUMO interaction motif 1 (SIM); crucial for efficient sumoylation

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing & Alternative initiation.

Q62599-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Name
    1
  • Synonyms
    MTA1, MTA1p
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Length
    703
  • Mass (Da)
    79,412
  • Last updated
    1996-11-01 v1
  • Checksum
    F05D8D287C45F13A
MAANMYRVGDYVYFENSSSNPYLIRRIEELNKTANGNVEAKVVCFYRRRDISSSLIALADKHATLSVCYRAGPGADTGEEGEVEEEVENPEMVDLPEKLKHQLRHRELFLSRQLESLPATHIRGKCSVTLLNETESLKSYLEREDFFFYSLVYDPQQKTLLADKGEIRVGNRYQADITDLLKDGEEDGRDQSKLETKVWEAHNPLVDKQIDQFLVVARSVGTFARALDCSSSVRQPSLHMSAAAASRDITLFHAMDTLHKNIYDISKAISALVPQGGPVLCRDEMEEWSASEANLFEEALEKYGKDFTDIQQDFLPWKSLTSIIEYYYMWKTTDRYVQQKRLKAAEAESKLKQVYIPNYNKPNPNQISVNSVKASVVNGTGTPGQSPGAGRACESCYTTQSYQWYSWGPPNMQCRLCASCWTYWKKYGGLKMPTRLDGERPGPNRNNMSPHGIPARSSGSPKFAMKTRQAFYLHTTKLTRIARRLCREILRPWHAARHPYMPINSAAIKAECTARLPEASQSPLVLKQVVRKPLEAVLRYLETHPRPPKPDPVKSSSSVLSSLTPAKSAPVINNGSPTILGKRSYEQHNGVDGLANHGQTRHMGPSRNLLLNGKSYPTKVRLIRGGSLPPVKRRRMNWIDAPDDVFYMATEETRKIRKLLSSSETKRAARRPYKPIALRQSQALPLRPPPPAPVNDEPIVIED

Q62599-2

  • Name
    2
  • Synonyms
    ZG29, ZG29p
  • Note
    Produced by alternative splicing and alternative initiation at Met-465 of isoform 1.
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There are 7 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8I6AHP2A0A8I6AHP2_RATMta1733
A0A8I6AM20A0A8I6AM20_RATMta1732
A0A140TA98A0A140TA98_RATMta1719
A0A8I5XZU2A0A8I5XZU2_RATMta1742
A0A8I6A1S8A0A8I6A1S8_RATMta1708
A0A8I5ZPI0A0A8I5ZPI0_RATMta1716
F1LQS1F1LQS1_RATMta1701

Features

Showing features for alternative sequence, compositional bias.

TypeIDPosition(s)Description
Alternative sequenceVSP_0197121-464in isoform 2
Compositional bias554-583Polar residues
Alternative sequenceVSP_019713593in isoform 2

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U02522
EMBL· GenBank· DDBJ
AAA82722.1
EMBL· GenBank· DDBJ
mRNA
AJ132046
EMBL· GenBank· DDBJ
CAB38718.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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