Q62599 · MTA1_RAT
- ProteinMetastasis-associated protein MTA1
- GeneMta1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids703 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Transcriptional coregulator which can act as both a transcriptional corepressor and coactivator (By similarity).
Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (By similarity).
In the NuRD complex, regulates transcription of its targets by modifying the acetylation status of the target chromatin and cofactor accessibility to the target DNA (By similarity).
In conjunction with other components of NuRD, acts as a transcriptional corepressor of BRCA1, ESR1, TFF1 and CDKN1A (By similarity).
Acts as a transcriptional coactivator of BCAS3, and SUMO2, independent of the NuRD complex (By similarity).
Stimulates the expression of WNT1 by inhibiting the expression of its transcriptional corepressor SIX3 (By similarity).
Regulates p53-dependent and -independent DNA repair processes following genotoxic stress (By similarity).
Regulates the stability and function of p53/TP53 by inhibiting its ubiquitination by COP1 and MDM2 thereby regulating the p53-dependent DNA repair (By similarity).
Plays a role in the regulation of the circadian clock and is essential for the generation and maintenance of circadian rhythms under constant light and for normal entrainment of behavior to light-dark (LD) cycles (By similarity).
Positively regulates the CLOCK-BMAL1 heterodimer mediated transcriptional activation of its own transcription and the transcription of CRY1 (By similarity).
Regulates deacetylation of BMAL1 by regulating SIRT1 expression, resulting in derepressing CRY1-mediated transcription repression (By similarity).
With TFCP2L1, promotes establishment and maintenance of pluripotency in embryonic stem cells (ESCs) and inhibits endoderm differentiation (By similarity).
Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (By similarity).
In the NuRD complex, regulates transcription of its targets by modifying the acetylation status of the target chromatin and cofactor accessibility to the target DNA (By similarity).
In conjunction with other components of NuRD, acts as a transcriptional corepressor of BRCA1, ESR1, TFF1 and CDKN1A (By similarity).
Acts as a transcriptional coactivator of BCAS3, and SUMO2, independent of the NuRD complex (By similarity).
Stimulates the expression of WNT1 by inhibiting the expression of its transcriptional corepressor SIX3 (By similarity).
Regulates p53-dependent and -independent DNA repair processes following genotoxic stress (By similarity).
Regulates the stability and function of p53/TP53 by inhibiting its ubiquitination by COP1 and MDM2 thereby regulating the p53-dependent DNA repair (By similarity).
Plays a role in the regulation of the circadian clock and is essential for the generation and maintenance of circadian rhythms under constant light and for normal entrainment of behavior to light-dark (LD) cycles (By similarity).
Positively regulates the CLOCK-BMAL1 heterodimer mediated transcriptional activation of its own transcription and the transcription of CRY1 (By similarity).
Regulates deacetylation of BMAL1 by regulating SIRT1 expression, resulting in derepressing CRY1-mediated transcription repression (By similarity).
With TFCP2L1, promotes establishment and maintenance of pluripotency in embryonic stem cells (ESCs) and inhibits endoderm differentiation (By similarity).
GO annotations
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMetastasis-associated protein MTA1
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionQ62599
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Isoform 1
Note: Associated with microtubules. Localization at the nuclear envelope is TPR-dependent (By similarity).
Isoform 2
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, cross-link, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000083495 | 1-703 | Metastasis-associated protein MTA1 | |||
Sequence: MAANMYRVGDYVYFENSSSNPYLIRRIEELNKTANGNVEAKVVCFYRRRDISSSLIALADKHATLSVCYRAGPGADTGEEGEVEEEVENPEMVDLPEKLKHQLRHRELFLSRQLESLPATHIRGKCSVTLLNETESLKSYLEREDFFFYSLVYDPQQKTLLADKGEIRVGNRYQADITDLLKDGEEDGRDQSKLETKVWEAHNPLVDKQIDQFLVVARSVGTFARALDCSSSVRQPSLHMSAAAASRDITLFHAMDTLHKNIYDISKAISALVPQGGPVLCRDEMEEWSASEANLFEEALEKYGKDFTDIQQDFLPWKSLTSIIEYYYMWKTTDRYVQQKRLKAAEAESKLKQVYIPNYNKPNPNQISVNSVKASVVNGTGTPGQSPGAGRACESCYTTQSYQWYSWGPPNMQCRLCASCWTYWKKYGGLKMPTRLDGERPGPNRNNMSPHGIPARSSGSPKFAMKTRQAFYLHTTKLTRIARRLCREILRPWHAARHPYMPINSAAIKAECTARLPEASQSPLVLKQVVRKPLEAVLRYLETHPRPPKPDPVKSSSSVLSSLTPAKSAPVINNGSPTILGKRSYEQHNGVDGLANHGQTRHMGPSRNLLLNGKSYPTKVRLIRGGSLPPVKRRRMNWIDAPDDVFYMATEETRKIRKLLSSSETKRAARRPYKPIALRQSQALPLRPPPPAPVNDEPIVIED | ||||||
Cross-link | 182 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) | ||||
Sequence: K | ||||||
Modified residue | 386 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 449 | Phosphoserine | ||||
Sequence: S | ||||||
Cross-link | 509 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2 and SUMO3) | ||||
Sequence: K | ||||||
Modified residue | 522 | Phosphoserine | ||||
Sequence: S | ||||||
Cross-link | 549 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) | ||||
Sequence: K | ||||||
Modified residue | 564 | Phosphothreonine | ||||
Sequence: T | ||||||
Modified residue | 576 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 578 | Phosphothreonine | ||||
Sequence: T | ||||||
Modified residue | 614 | N6-acetyllysine; alternate | ||||
Sequence: K | ||||||
Cross-link | 614 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate | ||||
Sequence: K | ||||||
Modified residue | 627 | Phosphoserine | ||||
Sequence: S |
Post-translational modification
Phosphorylation by CSNK1G2/CK1 triggered by estrogen enhances corepression of estrogen receptor (ER).
Acetylation is essential for its transcriptional coactivator activity.
Sumoylation positively regulates its transcriptional corepressor activity but does not affect the protein stability. Sumoylated preferentially by SUMO2 or SUMO3 than SUMO1. Sumoylation is enhanced by PIAS1/3/4 and preferentially sumoylated by SUMO2 in the presence of PIAS1/3/4. Desumoylated by SENP1 (By similarity).
Ubiquitinated by COP1, which leads to proteasomal degradation.
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Isoform 1 abundant in testis and expressed at low levels in brain, heart, lung, liver, and kidney. Isoform 2 abundant in adrenal gland, brain, colon, heart, liver, lung, muscle, prostate, stomach, testis, and thymus and expressed at low levels in duodenum, kidney, pancreas, parotid, and spleen.
Induction
Isoform 1
Induced by dexamethasone and, in pancreas, by treatment with the proteinase inhibitor FOY-305 which binds to activated trypsin and induces release of cholecystokinin.
Developmental stage
Isoform 1
Highly expressed in metastatic cells.
Interaction
Subunit
Component of the nucleosome remodeling and deacetylase (NuRD) repressor complex, composed of core proteins MTA1, MTA2, MTA3, RBBP4, RBBP7, HDAC1, HDAC2, MBD2, MBD3, and peripherally associated proteins CDK2AP1, CDK2AP2, GATAD2A, GATAD2B, CHD3, CHD4 and CHD5 (By similarity).
The exact stoichiometry of the NuRD complex is unknown, and some subunits such as MBD2 and MBD3, GATAD2A and GATAD2B, and CHD3, CHD4 and CHD5 define mutually exclusive NuRD complexes (By similarity).
Interacts with RBBP4; the interaction is direct (By similarity).
Interacts with BMAL1. Interacts with CLOCK. Interacts with COP1. Interacts with CSNK1G2 in the cytoplasm. Interacts with EP300. Interacts with HDAC2 (By similarity).
Interacts with ITGB3BP/CENPR (By similarity).
Interacts with MBD3L2 (By similarity).
Interacts with MDM2 (By similarity).
Interacts with NACC2 (By similarity).
Interacts with p53/TP53. Interacts with PIAS1. Interacts with PIAS3. Interacts with PIAS4. Interacts with PWWP2A. Interacts with PWWP2B. Interacts with SENP1. Interacts with SENP2. Interacts with SIX3; facilitates the binding of SIX3 to the core DNA motif of SIX3 promoter. Interacts with SUMO1. Interacts with SUMO2. Interacts with TFCP2L1; which is indispensable for TFCP2L1-mediated self-renewal-promoting effect and endoderm-inhibiting action (By similarity).
Interacts with TFAP2C (By similarity).
Interacts with TPR. Interacts with UBE2I/UBC9 (By similarity).
The exact stoichiometry of the NuRD complex is unknown, and some subunits such as MBD2 and MBD3, GATAD2A and GATAD2B, and CHD3, CHD4 and CHD5 define mutually exclusive NuRD complexes (By similarity).
Interacts with RBBP4; the interaction is direct (By similarity).
Interacts with BMAL1. Interacts with CLOCK. Interacts with COP1. Interacts with CSNK1G2 in the cytoplasm. Interacts with EP300. Interacts with HDAC2 (By similarity).
Interacts with ITGB3BP/CENPR (By similarity).
Interacts with MBD3L2 (By similarity).
Interacts with MDM2 (By similarity).
Interacts with NACC2 (By similarity).
Interacts with p53/TP53. Interacts with PIAS1. Interacts with PIAS3. Interacts with PIAS4. Interacts with PWWP2A. Interacts with PWWP2B. Interacts with SENP1. Interacts with SENP2. Interacts with SIX3; facilitates the binding of SIX3 to the core DNA motif of SIX3 promoter. Interacts with SUMO1. Interacts with SUMO2. Interacts with TFCP2L1; which is indispensable for TFCP2L1-mediated self-renewal-promoting effect and endoderm-inhibiting action (By similarity).
Interacts with TFAP2C (By similarity).
Interacts with TPR. Interacts with UBE2I/UBC9 (By similarity).
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q62599 | Six3 Q9ET75 | 2 | EBI-349237, EBI-15649593 |
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, zinc finger, region, motif, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-164 | BAH | ||||
Sequence: MAANMYRVGDYVYFENSSSNPYLIRRIEELNKTANGNVEAKVVCFYRRRDISSSLIALADKHATLSVCYRAGPGADTGEEGEVEEEVENPEMVDLPEKLKHQLRHRELFLSRQLESLPATHIRGKCSVTLLNETESLKSYLEREDFFFYSLVYDPQQKTLLADK | ||||||
Domain | 165-276 | ELM2 | ||||
Sequence: GEIRVGNRYQADITDLLKDGEEDGRDQSKLETKVWEAHNPLVDKQIDQFLVVARSVGTFARALDCSSSVRQPSLHMSAAAASRDITLFHAMDTLHKNIYDISKAISALVPQG | ||||||
Domain | 283-335 | SANT | ||||
Sequence: DEMEEWSASEANLFEEALEKYGKDFTDIQQDFLPWKSLTSIIEYYYMWKTTDR | ||||||
Zinc finger | 393-420 | GATA-type; atypical | ||||
Sequence: CESCYTTQSYQWYSWGPPNMQCRLCASC | ||||||
Region | 437-460 | Disordered | ||||
Sequence: DGERPGPNRNNMSPHGIPARSSGS | ||||||
Region | 542-583 | Disordered | ||||
Sequence: ETHPRPPKPDPVKSSSSVLSSLTPAKSAPVINNGSPTILGKR | ||||||
Motif | 545-552 | SH3-binding | ||||
Sequence: PRPPKPDP | ||||||
Compositional bias | 554-583 | Polar residues | ||||
Sequence: KSSSSVLSSLTPAKSAPVINNGSPTILGKR | ||||||
Region | 644-674 | Interaction with RBBP4 | ||||
Sequence: DVFYMATEETRKIRKLLSSSETKRAARRPYK | ||||||
Region | 661-703 | Disordered | ||||
Sequence: SSSETKRAARRPYKPIALRQSQALPLRPPPPAPVNDEPIVIED | ||||||
Motif | 684-693 | SH3-binding | ||||
Sequence: LPLRPPPPAP | ||||||
Motif | 699-703 | SUMO interaction motif 1 (SIM); crucial for efficient sumoylation | ||||
Sequence: IVIED |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing & Alternative initiation.
Q62599-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- SynonymsMTA1, MTA1p
- Length703
- Mass (Da)79,412
- Last updated1996-11-01 v1
- ChecksumF05D8D287C45F13A
Q62599-2
- Name2
- SynonymsZG29, ZG29p
- NoteProduced by alternative splicing and alternative initiation at Met-465 of isoform 1.
Computationally mapped potential isoform sequences
There are 7 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8I6AHP2 | A0A8I6AHP2_RAT | Mta1 | 733 | ||
A0A8I6AM20 | A0A8I6AM20_RAT | Mta1 | 732 | ||
A0A140TA98 | A0A140TA98_RAT | Mta1 | 719 | ||
A0A8I5XZU2 | A0A8I5XZU2_RAT | Mta1 | 742 | ||
A0A8I6A1S8 | A0A8I6A1S8_RAT | Mta1 | 708 | ||
A0A8I5ZPI0 | A0A8I5ZPI0_RAT | Mta1 | 716 | ||
F1LQS1 | F1LQS1_RAT | Mta1 | 701 |
Features
Showing features for alternative sequence, compositional bias.
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
U02522 EMBL· GenBank· DDBJ | AAA82722.1 EMBL· GenBank· DDBJ | mRNA | ||
AJ132046 EMBL· GenBank· DDBJ | CAB38718.1 EMBL· GenBank· DDBJ | mRNA |