Q62563 · SRY_MUSSP
- ProteinSex-determining region Y protein
- GeneSry
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids355 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. Involved in different aspects of gene regulation including promoter activation or repression. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'. SRY HMG box recognizes DNA by partial intercalation in the minor groove and promotes DNA bending. Also involved in pre-mRNA splicing (By similarity).
In male adult brain involved in the maintenance of motor functions of dopaminergic neurons (By similarity).
In male adult brain involved in the maintenance of motor functions of dopaminergic neurons (By similarity).
Features
Showing features for dna binding.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
DNA binding | 5-73 | HMG box | ||||
Sequence: VKRPMNAFMVWSRGERHKLAQQNPSMQNTEISKQLGCRWKSLTEAEKRPFFQEAQRLKTLHREKYPNYK |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | nuclear speck | |
Cellular Component | nucleus | |
Molecular Function | calmodulin binding | |
Molecular Function | DNA-binding transcription activator activity, RNA polymerase II-specific | |
Molecular Function | RNA polymerase II cis-regulatory region sequence-specific DNA binding | |
Biological Process | anatomical structure morphogenesis | |
Biological Process | brain development | |
Biological Process | negative regulation of transcription by RNA polymerase II | |
Biological Process | neuron differentiation | |
Biological Process | positive regulation of gene expression | |
Biological Process | positive regulation of transcription by RNA polymerase II | |
Biological Process | sex differentiation |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameSex-determining region Y protein
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ62563
Organism-specific databases
Subcellular Location
Phenotypes & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | 274 | |||||
Sequence: K → R |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 1 variant from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000048689 | 1-355 | Sex-determining region Y protein | |||
Sequence: MEGHVKRPMNAFMVWSRGERHKLAQQNPSMQNTEISKQLGCRWKSLTEAEKRPFFQEAQRLKTLHREKYPNYKYQPHRRAKVSQRSGILQPRVASTKLYNLLQWDRNPHAITYRQDWSRAAHLYSKNQQSFYLQPVDIPTGHPQQQQQQFHNHHQQKQQFHDHHQQKQQFHDHHQQQQQFHDHQQQQQQFHDHQQQKQQFHDHQQQQQQFHDHHHQQQQQQFHDHHHHQQQQQQFHDHHQQKQQFHDHHQQQQQQQFHDHPQQQQQFHDHPQQKQQFHDHHHHQQQKQQFHDHHQQKQQFHDHHQQQQQFHDHQQQQQQQQFHDQQLTYLLTADITGEHTPYQEHLSKALWLAVS |
Post-translational modification
Acetylation of Lys-81 contributes to its nuclear localization and enhances its interaction with KPNB1. Deacetylated by HDAC3.
Keywords
- PTM
Interaction
Subunit
Interacts with CALM, EP300, HDAC3, KPNB1, ZNF208 isoform KRAB-O, PARP1, SLC9A3R2 and WT1. The interaction with EP300 modulates its DNA-binding activity. The interaction with KPNB1 is sensitive to dissociation by Ran in the GTP-bound form. Interaction with PARP1 impaired its DNA-binding activity.
Structure
Family & Domains
Features
Showing features for compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 135-154 | Polar residues | ||||
Sequence: PVDIPTGHPQQQQQQFHNHH | ||||||
Region | 135-322 | Disordered | ||||
Sequence: PVDIPTGHPQQQQQQFHNHHQQKQQFHDHHQQKQQFHDHHQQQQQFHDHQQQQQQFHDHQQQKQQFHDHQQQQQQFHDHHHQQQQQQFHDHHHHQQQQQQFHDHHQQKQQFHDHHQQQQQQQFHDHPQQQQQFHDHPQQKQQFHDHHHHQQQKQQFHDHHQQKQQFHDHHQQQQQFHDHQQQQQQQQF | ||||||
Compositional bias | 155-179 | Basic and acidic residues | ||||
Sequence: QQKQQFHDHHQQKQQFHDHHQQQQQ | ||||||
Compositional bias | 180-205 | Polar residues | ||||
Sequence: FHDHQQQQQQFHDHQQQKQQFHDHQQ | ||||||
Compositional bias | 206-246 | Basic and acidic residues | ||||
Sequence: QQQQFHDHHHQQQQQQFHDHHHHQQQQQQFHDHHQQKQQFH | ||||||
Compositional bias | 247-271 | Polar residues | ||||
Sequence: DHHQQQQQQQFHDHPQQQQQFHDHP | ||||||
Compositional bias | 272-309 | Basic and acidic residues | ||||
Sequence: QQKQQFHDHHHHQQQKQQFHDHHQQKQQFHDHHQQQQQ |
Domain
The Gln- and His-rich domain may mediate protein-protein interactions.
Sequence similarities
Belongs to the SRY family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length355
- Mass (Da)44,260
- Last updated1998-07-15 v2
- Checksum0903265F7A173EFC
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 135-154 | Polar residues | ||||
Sequence: PVDIPTGHPQQQQQQFHNHH | ||||||
Compositional bias | 155-179 | Basic and acidic residues | ||||
Sequence: QQKQQFHDHHQQKQQFHDHHQQQQQ | ||||||
Compositional bias | 180-205 | Polar residues | ||||
Sequence: FHDHQQQQQQFHDHQQQKQQFHDHQQ | ||||||
Compositional bias | 206-246 | Basic and acidic residues | ||||
Sequence: QQQQFHDHHHQQQQQQFHDHHHHQQQQQQFHDHHQQKQQFH | ||||||
Compositional bias | 247-271 | Polar residues | ||||
Sequence: DHHQQQQQQQFHDHPQQQQQFHDHP | ||||||
Compositional bias | 272-309 | Basic and acidic residues | ||||
Sequence: QQKQQFHDHHHHQQQKQQFHDHHQQKQQFHDHHQQQQQ |