Q62563 · SRY_MUSSP

Function

function

Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. Involved in different aspects of gene regulation including promoter activation or repression. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'. SRY HMG box recognizes DNA by partial intercalation in the minor groove and promotes DNA bending. Also involved in pre-mRNA splicing (By similarity).
In male adult brain involved in the maintenance of motor functions of dopaminergic neurons (By similarity).

Features

Showing features for dna binding.

135550100150200250300350
TypeIDPosition(s)Description
DNA binding5-73HMG box

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentnuclear speck
Cellular Componentnucleus
Molecular Functioncalmodulin binding
Molecular FunctionDNA-binding transcription activator activity, RNA polymerase II-specific
Molecular FunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding
Biological Processanatomical structure morphogenesis
Biological Processbrain development
Biological Processnegative regulation of transcription by RNA polymerase II
Biological Processneuron differentiation
Biological Processpositive regulation of gene expression
Biological Processpositive regulation of transcription by RNA polymerase II
Biological Processsex differentiation

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Sex-determining region Y protein
  • Alternative names
    • Testis-determining factor

Gene names

    • Name
      Sry
    • Synonyms
      Tdf

Organism names

Accessions

  • Primary accession
    Q62563

Organism-specific databases

Subcellular Location

Keywords

Phenotypes & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variant274

Variants

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The viewer provides 1 variant from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000486891-355Sex-determining region Y protein

Post-translational modification

Acetylation of Lys-81 contributes to its nuclear localization and enhances its interaction with KPNB1. Deacetylated by HDAC3.

Keywords

Interaction

Subunit

Interacts with CALM, EP300, HDAC3, KPNB1, ZNF208 isoform KRAB-O, PARP1, SLC9A3R2 and WT1. The interaction with EP300 modulates its DNA-binding activity. The interaction with KPNB1 is sensitive to dissociation by Ran in the GTP-bound form. Interaction with PARP1 impaired its DNA-binding activity.

Structure

Family & Domains

Features

Showing features for compositional bias, region.

TypeIDPosition(s)Description
Compositional bias135-154Polar residues
Region135-322Disordered
Compositional bias155-179Basic and acidic residues
Compositional bias180-205Polar residues
Compositional bias206-246Basic and acidic residues
Compositional bias247-271Polar residues
Compositional bias272-309Basic and acidic residues

Domain

The Gln- and His-rich domain may mediate protein-protein interactions.

Sequence similarities

Belongs to the SRY family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    355
  • Mass (Da)
    44,260
  • Last updated
    1998-07-15 v2
  • Checksum
    0903265F7A173EFC
MEGHVKRPMNAFMVWSRGERHKLAQQNPSMQNTEISKQLGCRWKSLTEAEKRPFFQEAQRLKTLHREKYPNYKYQPHRRAKVSQRSGILQPRVASTKLYNLLQWDRNPHAITYRQDWSRAAHLYSKNQQSFYLQPVDIPTGHPQQQQQQFHNHHQQKQQFHDHHQQKQQFHDHHQQQQQFHDHQQQQQQFHDHQQQKQQFHDHQQQQQQFHDHHHQQQQQQFHDHHHHQQQQQQFHDHHQQKQQFHDHHQQQQQQQFHDHPQQQQQFHDHPQQKQQFHDHHHHQQQKQQFHDHHQQKQQFHDHHQQQQQFHDHQQQQQQQQFHDQQLTYLLTADITGEHTPYQEHLSKALWLAVS

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias135-154Polar residues
Compositional bias155-179Basic and acidic residues
Compositional bias180-205Polar residues
Compositional bias206-246Basic and acidic residues
Compositional bias247-271Polar residues
Compositional bias272-309Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U70659
EMBL· GenBank· DDBJ
AAC53449.1
EMBL· GenBank· DDBJ
Genomic DNA
AF009521
EMBL· GenBank· DDBJ
AAC53452.1
EMBL· GenBank· DDBJ
Genomic DNA
L29544
EMBL· GenBank· DDBJ
AAA40102.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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