Q62422 · OSTF1_MOUSE
- ProteinOsteoclast-stimulating factor 1
- GeneOstf1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids215 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Induces bone resorption, acting probably through a signaling cascade which results in the secretion of factor(s) enhancing osteoclast formation and activity.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | SH3 domain binding | |
Biological Process | signal transduction |
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameOsteoclast-stimulating factor 1
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ62422
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for initiator methionine, modified residue, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Initiator methionine | 1 | Removed | ||||
Sequence: M | ||||||
Modified residue | 2 | N-acetylserine | ||||
Sequence: S | ||||||
Chain | PRO_0000067036 | 2-215 | Osteoclast-stimulating factor 1 | |||
Sequence: SKPPPKPVKPGQVKVFRALYTFEPRTPDELYFEEGDIIYITDMSDTSWWKGTCKGRTGLIPSNYVAEQAESIDNPLHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGHKDIVEVLFTQPNVELNQQNKLGDTALHAAAWKGYADIVQLLLAKGARTDLRNNEKKLALDMATNAACASLLKKKQQGTDGARTLSNAEDYLDDEDSD | ||||||
Modified residue | 201 | Phosphothreonine | ||||
Sequence: T | ||||||
Modified residue | 203 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 214 | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain, repeat, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 12-71 | SH3 | ||||
Sequence: GQVKVFRALYTFEPRTPDELYFEEGDIIYITDMSDTSWWKGTCKGRTGLIPSNYVAEQAE | ||||||
Repeat | 72-101 | ANK 1 | ||||
Sequence: SIDNPLHEAAKRGNLSWLRECLDNRVGVNG | ||||||
Repeat | 105-135 | ANK 2 | ||||
Sequence: AGSTALYWACHGGHKDIVEVLFTQPNVELNQ | ||||||
Repeat | 139-168 | ANK 3 | ||||
Sequence: LGDTALHAAAWKGYADIVQLLLAKGARTDL | ||||||
Region | 192-215 | Disordered | ||||
Sequence: KQQGTDGARTLSNAEDYLDDEDSD |
Domain
The SH3 domain mediates interaction with SMN1.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length215
- Mass (Da)23,783
- Last updated2000-12-01 v2
- ChecksumDAB682C371929B8A
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A494B943 | A0A494B943_MOUSE | Ostf1 | 38 | ||
A0A494BA97 | A0A494BA97_MOUSE | Ostf1 | 212 |
Sequence caution
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
U58888 EMBL· GenBank· DDBJ | AAC52641.1 EMBL· GenBank· DDBJ | mRNA | Different initiation | |
AK002899 EMBL· GenBank· DDBJ | BAB22442.1 EMBL· GenBank· DDBJ | mRNA | ||
AK005525 EMBL· GenBank· DDBJ | BAB24098.1 EMBL· GenBank· DDBJ | mRNA | ||
AK008123 EMBL· GenBank· DDBJ | BAB25477.1 EMBL· GenBank· DDBJ | mRNA | ||
AK008467 EMBL· GenBank· DDBJ | BAB25685.1 EMBL· GenBank· DDBJ | mRNA | ||
AK010074 EMBL· GenBank· DDBJ | BAB26683.1 EMBL· GenBank· DDBJ | mRNA | ||
AK145949 EMBL· GenBank· DDBJ | BAE26777.1 EMBL· GenBank· DDBJ | mRNA | ||
AK149175 EMBL· GenBank· DDBJ | BAE28756.1 EMBL· GenBank· DDBJ | mRNA | ||
AK150145 EMBL· GenBank· DDBJ | BAE29340.1 EMBL· GenBank· DDBJ | mRNA | ||
AK155028 EMBL· GenBank· DDBJ | BAE33000.1 EMBL· GenBank· DDBJ | mRNA | ||
BC060986 EMBL· GenBank· DDBJ | AAH60986.1 EMBL· GenBank· DDBJ | mRNA |