Q62422 · OSTF1_MOUSE

  • Protein
    Osteoclast-stimulating factor 1
  • Gene
    Ostf1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    3/5

Function

function

Induces bone resorption, acting probably through a signaling cascade which results in the secretion of factor(s) enhancing osteoclast formation and activity.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Molecular FunctionSH3 domain binding
Biological Processsignal transduction

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Osteoclast-stimulating factor 1
  • Alternative names
    • SH3 domain protein 3

Gene names

    • Name
      Ostf1
    • Synonyms
      Sh3d3, Sh3p2

Organism names

  • Taxonomic identifier
  • Strains
    • C57BL/6J
    • NOD
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q62422
  • Secondary accessions
    • Q3UF05

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for initiator methionine, modified residue, chain.

TypeIDPosition(s)Description
Initiator methionine1Removed
Modified residue2N-acetylserine
ChainPRO_00000670362-215Osteoclast-stimulating factor 1
Modified residue201Phosphothreonine
Modified residue203Phosphoserine
Modified residue214Phosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Interacts with C-SRC and SMN1. Interacts with FASLG (By similarity).

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for domain, repeat, region.

TypeIDPosition(s)Description
Domain12-71SH3
Repeat72-101ANK 1
Repeat105-135ANK 2
Repeat139-168ANK 3
Region192-215Disordered

Domain

The SH3 domain mediates interaction with SMN1.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    215
  • Mass (Da)
    23,783
  • Last updated
    2000-12-01 v2
  • Checksum
    DAB682C371929B8A
MSKPPPKPVKPGQVKVFRALYTFEPRTPDELYFEEGDIIYITDMSDTSWWKGTCKGRTGLIPSNYVAEQAESIDNPLHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGHKDIVEVLFTQPNVELNQQNKLGDTALHAAAWKGYADIVQLLLAKGARTDLRNNEKKLALDMATNAACASLLKKKQQGTDGARTLSNAEDYLDDEDSD

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A494B943A0A494B943_MOUSEOstf138
A0A494BA97A0A494BA97_MOUSEOstf1212

Sequence caution

The sequence AAC52641.1 differs from that shown. Reason: Erroneous initiation

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U58888
EMBL· GenBank· DDBJ
AAC52641.1
EMBL· GenBank· DDBJ
mRNA Different initiation
AK002899
EMBL· GenBank· DDBJ
BAB22442.1
EMBL· GenBank· DDBJ
mRNA
AK005525
EMBL· GenBank· DDBJ
BAB24098.1
EMBL· GenBank· DDBJ
mRNA
AK008123
EMBL· GenBank· DDBJ
BAB25477.1
EMBL· GenBank· DDBJ
mRNA
AK008467
EMBL· GenBank· DDBJ
BAB25685.1
EMBL· GenBank· DDBJ
mRNA
AK010074
EMBL· GenBank· DDBJ
BAB26683.1
EMBL· GenBank· DDBJ
mRNA
AK145949
EMBL· GenBank· DDBJ
BAE26777.1
EMBL· GenBank· DDBJ
mRNA
AK149175
EMBL· GenBank· DDBJ
BAE28756.1
EMBL· GenBank· DDBJ
mRNA
AK150145
EMBL· GenBank· DDBJ
BAE29340.1
EMBL· GenBank· DDBJ
mRNA
AK155028
EMBL· GenBank· DDBJ
BAE33000.1
EMBL· GenBank· DDBJ
mRNA
BC060986
EMBL· GenBank· DDBJ
AAH60986.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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