Q62420 · SH3G2_MOUSE

  • Protein
    Endophilin-A1
  • Gene
    Sh3gl2
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature. Required for BDNF-dependent dendrite outgrowth (PubMed:21849472).
Cooperates with SH3GL2 to mediate BDNF-NTRK2 early endocytic trafficking and signaling from early endosomes (PubMed:21849472).

Caution

Was originally thought to have lysophosphatidic acid acyltransferase activity, but has since been experimentally shown not to have this activity.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentbasal dendrite
Cellular Componentcytoplasm
Cellular Componentearly endosome
Cellular Componentglutamatergic synapse
Cellular Componenthippocampal mossy fiber to CA3 synapse
Cellular Componentneuronal cell body
Cellular Componentperinuclear region of cytoplasm
Cellular Componentphotoreceptor ribbon synapse
Cellular Componentpostsynapse
Cellular Componentpresynapse
Cellular Componentpresynaptic cytosol
Cellular ComponentSchaffer collateral - CA1 synapse
Cellular Componentsynapse
Cellular Componentsynaptic vesicle membrane
Molecular Functionidentical protein binding
Molecular Functionlipid binding
Molecular Functionprotein kinase binding
Molecular Functiontransmembrane transporter binding
Biological Processcellular response to brain-derived neurotrophic factor stimulus
Biological Processdendrite extension
Biological Processlipid tube assembly
Biological Processmembrane bending
Biological Processmembrane tubulation
Biological Processneuron projection development
Biological Processpositive regulation of membrane tubulation
Biological Processpostsynaptic actin cytoskeleton organization
Biological Processregulation of clathrin-dependent endocytosis
Biological Processregulation of receptor internalization
Biological Processsynaptic vesicle endocytosis
Biological Processsynaptic vesicle uncoating
Biological Processvesicle scission

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Endophilin-A1
  • Alternative names
    • Endophilin-1
    • SH3 domain protein 2A
    • SH3 domain-containing GRB2-like protein 2
    • SH3p4

Gene names

    • Name
      Sh3gl2
    • Synonyms
      Een1
      , Sh3d2a

Organism names

  • Taxonomic identifier
  • Strains
    • C57BL/6J
    • DBA/2J
    • OF1
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q62420
  • Secondary accessions
    • Q3UTL7
    • Q3UY49
    • Q8BXS6
    • Q8VBV1

Proteomes

Organism-specific databases

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00001467481-352Endophilin-A1
Modified residue262Phosphoserine
Modified residue299Phosphotyrosine

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Monomer; in cytoplasm. Homodimer; when associated with membranes (By similarity).
Interacts with SYNJ1 (By similarity).
Interacts with DNM1 (PubMed:10490020).
Interacts with MAP4K3; the interaction appears to regulate MAP4K3-mediated JNK activation (By similarity).
Interacts with OPHN1 (PubMed:19481455).
Interacts with PDCD6IP (By similarity).
Interacts with BIN2 (By similarity).
Interacts with ATXN2 (PubMed:18602463).
Interacts with ADAM9 and ADAM15 cytoplasmic tails (PubMed:10531379).
Interacts with TMEM108 (PubMed:21849472).
Interacts with ADGRB2 (PubMed:28891236).

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q62420Dennd1a Q8K3822EBI-77971, EBI-7186684
BINARY Q62420Sh3gl2 Q624202EBI-77971, EBI-77971

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for region, domain, coiled coil, compositional bias.

TypeIDPosition(s)Description
Region1-21Membrane-binding amphipathic helix
Region1-27Disordered
Region1-125Binds and tubulates liposomes
Domain18-249BAR
Region60-87Required for dimerization upon membrane association
Coiled coil181-248
Region264-289Disordered
Compositional bias265-279Polar residues
Domain290-349SH3

Domain

An N-terminal amphipathic helix, the BAR domain and a second amphipathic helix inserted into helix 1 of the BAR domain (N-BAR domain) induce membrane curvature and bind curved membranes (By similarity).
The BAR domain dimer forms a rigid crescent shaped bundle of helices with the pair of second amphipathic helices protruding towards the membrane-binding surface

Sequence similarities

Belongs to the endophilin family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    352
  • Mass (Da)
    39,955
  • Last updated
    2007-10-23 v2
  • Checksum
    8C2B6F0FB245DCD3
MSVAGLKKQFHKATQKVSEKVGGAEGTKLDDDFKEMERKVDVTSRAVMEIMTKTIEYLQPNPASRAKLSMINTMSKIRGQEKGPGYPQAEALLAEAMLKFGRELGDDCNFGPALGEVGEAMRELSEVKDSLDMEVKQNFIDPLQNLHDKDLREIQHHLKKLEGRRLDFDYKKKRQGKIPDEELRQALEKFDESKEIAESSMFNLLEMDIEQVSQLSALVQAQLEYHKQAVQILQQVTVRLEERIRQASSQPRREYQPKPRMSLEFATGDSTQPNGGLSHTGTPKPPGVQMDQPCCRALYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHGQSGFFPINYVEILVALPH

Computationally mapped potential isoform sequences

There are 4 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A2ALV1A2ALV1_MOUSESh3gl2182
A2ALV3A2ALV3_MOUSESh3gl2431
F6ZL13F6ZL13_MOUSESh3gl2231
Q8BXU5Q8BXU5_MOUSESh3gl2245

Features

Showing features for sequence conflict, compositional bias.

TypeIDPosition(s)Description
Sequence conflict28in Ref. 3; BAC31888
Sequence conflict54in Ref. 3; BAE23963
Sequence conflict69in Ref. 3; BAE23963
Sequence conflict169in Ref. 1; AAC71774
Compositional bias265-279Polar residues
Sequence conflict301in Ref. 1; AAC71774
Sequence conflict310in Ref. 1; AAC71774

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U58886
EMBL· GenBank· DDBJ
AAC71774.1
EMBL· GenBank· DDBJ
mRNA
AF326561
EMBL· GenBank· DDBJ
AAL37407.1
EMBL· GenBank· DDBJ
mRNA
AF326562
EMBL· GenBank· DDBJ
AAL37408.1
EMBL· GenBank· DDBJ
mRNA
AK044370
EMBL· GenBank· DDBJ
BAC31888.1
EMBL· GenBank· DDBJ
mRNA
AK134970
EMBL· GenBank· DDBJ
BAE22364.1
EMBL· GenBank· DDBJ
mRNA
AK139337
EMBL· GenBank· DDBJ
BAE23963.1
EMBL· GenBank· DDBJ
mRNA
AL805970
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AL806524
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC018385
EMBL· GenBank· DDBJ
AAH18385.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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