Q62420 · SH3G2_MOUSE
- ProteinEndophilin-A1
- GeneSh3gl2
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids352 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature. Required for BDNF-dependent dendrite outgrowth (PubMed:21849472).
Cooperates with SH3GL2 to mediate BDNF-NTRK2 early endocytic trafficking and signaling from early endosomes (PubMed:21849472).
Cooperates with SH3GL2 to mediate BDNF-NTRK2 early endocytic trafficking and signaling from early endosomes (PubMed:21849472).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Keywords
- Biological process
- Ligand
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameEndophilin-A1
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ62420
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000146748 | 1-352 | Endophilin-A1 | |||
Sequence: MSVAGLKKQFHKATQKVSEKVGGAEGTKLDDDFKEMERKVDVTSRAVMEIMTKTIEYLQPNPASRAKLSMINTMSKIRGQEKGPGYPQAEALLAEAMLKFGRELGDDCNFGPALGEVGEAMRELSEVKDSLDMEVKQNFIDPLQNLHDKDLREIQHHLKKLEGRRLDFDYKKKRQGKIPDEELRQALEKFDESKEIAESSMFNLLEMDIEQVSQLSALVQAQLEYHKQAVQILQQVTVRLEERIRQASSQPRREYQPKPRMSLEFATGDSTQPNGGLSHTGTPKPPGVQMDQPCCRALYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHGQSGFFPINYVEILVALPH | ||||||
Modified residue | 262 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 299 | Phosphotyrosine | ||||
Sequence: Y |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Gene expression databases
Interaction
Subunit
Monomer; in cytoplasm. Homodimer; when associated with membranes (By similarity).
Interacts with SYNJ1 (By similarity).
Interacts with DNM1 (PubMed:10490020).
Interacts with MAP4K3; the interaction appears to regulate MAP4K3-mediated JNK activation (By similarity).
Interacts with OPHN1 (PubMed:19481455).
Interacts with PDCD6IP (By similarity).
Interacts with BIN2 (By similarity).
Interacts with ATXN2 (PubMed:18602463).
Interacts with ADAM9 and ADAM15 cytoplasmic tails (PubMed:10531379).
Interacts with TMEM108 (PubMed:21849472).
Interacts with ADGRB2 (PubMed:28891236).
Interacts with SYNJ1 (By similarity).
Interacts with DNM1 (PubMed:10490020).
Interacts with MAP4K3; the interaction appears to regulate MAP4K3-mediated JNK activation (By similarity).
Interacts with OPHN1 (PubMed:19481455).
Interacts with PDCD6IP (By similarity).
Interacts with BIN2 (By similarity).
Interacts with ATXN2 (PubMed:18602463).
Interacts with ADAM9 and ADAM15 cytoplasmic tails (PubMed:10531379).
Interacts with TMEM108 (PubMed:21849472).
Interacts with ADGRB2 (PubMed:28891236).
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q62420 | Dennd1a Q8K382 | 2 | EBI-77971, EBI-7186684 | |
BINARY | Q62420 | Sh3gl2 Q62420 | 2 | EBI-77971, EBI-77971 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for region, domain, coiled coil, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-21 | Membrane-binding amphipathic helix | ||||
Sequence: MSVAGLKKQFHKATQKVSEKV | ||||||
Region | 1-27 | Disordered | ||||
Sequence: MSVAGLKKQFHKATQKVSEKVGGAEGT | ||||||
Region | 1-125 | Binds and tubulates liposomes | ||||
Sequence: MSVAGLKKQFHKATQKVSEKVGGAEGTKLDDDFKEMERKVDVTSRAVMEIMTKTIEYLQPNPASRAKLSMINTMSKIRGQEKGPGYPQAEALLAEAMLKFGRELGDDCNFGPALGEVGEAMRELS | ||||||
Domain | 18-249 | BAR | ||||
Sequence: SEKVGGAEGTKLDDDFKEMERKVDVTSRAVMEIMTKTIEYLQPNPASRAKLSMINTMSKIRGQEKGPGYPQAEALLAEAMLKFGRELGDDCNFGPALGEVGEAMRELSEVKDSLDMEVKQNFIDPLQNLHDKDLREIQHHLKKLEGRRLDFDYKKKRQGKIPDEELRQALEKFDESKEIAESSMFNLLEMDIEQVSQLSALVQAQLEYHKQAVQILQQVTVRLEERIRQASS | ||||||
Region | 60-87 | Required for dimerization upon membrane association | ||||
Sequence: PNPASRAKLSMINTMSKIRGQEKGPGYP | ||||||
Coiled coil | 181-248 | |||||
Sequence: EELRQALEKFDESKEIAESSMFNLLEMDIEQVSQLSALVQAQLEYHKQAVQILQQVTVRLEERIRQAS | ||||||
Region | 264-289 | Disordered | ||||
Sequence: EFATGDSTQPNGGLSHTGTPKPPGVQ | ||||||
Compositional bias | 265-279 | Polar residues | ||||
Sequence: FATGDSTQPNGGLSH | ||||||
Domain | 290-349 | SH3 | ||||
Sequence: MDQPCCRALYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHGQSGFFPINYVEILVA |
Domain
An N-terminal amphipathic helix, the BAR domain and a second amphipathic helix inserted into helix 1 of the BAR domain (N-BAR domain) induce membrane curvature and bind curved membranes (By similarity).
The BAR domain dimer forms a rigid crescent shaped bundle of helices with the pair of second amphipathic helices protruding towards the membrane-binding surface
The BAR domain dimer forms a rigid crescent shaped bundle of helices with the pair of second amphipathic helices protruding towards the membrane-binding surface
Sequence similarities
Belongs to the endophilin family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length352
- Mass (Da)39,955
- Last updated2007-10-23 v2
- Checksum8C2B6F0FB245DCD3
Computationally mapped potential isoform sequences
There are 4 potential isoforms mapped to this entry
Features
Showing features for sequence conflict, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 28 | in Ref. 3; BAC31888 | ||||
Sequence: K → N | ||||||
Sequence conflict | 54 | in Ref. 3; BAE23963 | ||||
Sequence: T → K | ||||||
Sequence conflict | 69 | in Ref. 3; BAE23963 | ||||
Sequence: S → G | ||||||
Sequence conflict | 169 | in Ref. 1; AAC71774 | ||||
Sequence: D → G | ||||||
Compositional bias | 265-279 | Polar residues | ||||
Sequence: FATGDSTQPNGGLSH | ||||||
Sequence conflict | 301 | in Ref. 1; AAC71774 | ||||
Sequence: F → L | ||||||
Sequence conflict | 310 | in Ref. 1; AAC71774 | ||||
Sequence: G → A |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
U58886 EMBL· GenBank· DDBJ | AAC71774.1 EMBL· GenBank· DDBJ | mRNA | ||
AF326561 EMBL· GenBank· DDBJ | AAL37407.1 EMBL· GenBank· DDBJ | mRNA | ||
AF326562 EMBL· GenBank· DDBJ | AAL37408.1 EMBL· GenBank· DDBJ | mRNA | ||
AK044370 EMBL· GenBank· DDBJ | BAC31888.1 EMBL· GenBank· DDBJ | mRNA | ||
AK134970 EMBL· GenBank· DDBJ | BAE22364.1 EMBL· GenBank· DDBJ | mRNA | ||
AK139337 EMBL· GenBank· DDBJ | BAE23963.1 EMBL· GenBank· DDBJ | mRNA | ||
AL805970 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL806524 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC018385 EMBL· GenBank· DDBJ | AAH18385.1 EMBL· GenBank· DDBJ | mRNA |