Q62087 · PON3_MOUSE

  • Protein
    Serum paraoxonase/lactonase 3
  • Gene
    Pon3
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents (By similarity).

Catalytic activity

Cofactor

Ca2+ (UniProtKB | Rhea| CHEBI:29108 )

Note: Binds 2 calcium ions per subunit.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site53Ca2+ 1 (UniProtKB | ChEBI); catalytic
Binding site54Ca2+ 2 (UniProtKB | ChEBI)
Active site114Proton acceptor
Binding site116Ca2+ 2 (UniProtKB | ChEBI)
Binding site167Ca2+ 1 (UniProtKB | ChEBI); catalytic
Binding site168Ca2+ 2 (UniProtKB | ChEBI)
Binding site223Ca2+ 1 (UniProtKB | ChEBI); catalytic
Binding site268Ca2+ 1 (UniProtKB | ChEBI); catalytic
Binding site269Ca2+ 1 (UniProtKB | ChEBI); catalytic

GO annotations

AspectTerm
Cellular Componentextracellular space
Molecular Function3,4-dihydrocoumarin hydrolase activity
Molecular Functionacyl-L-homoserine-lactone lactonohydrolase activity
Molecular Functionaryldialkylphosphatase activity
Molecular Functionarylesterase activity
Molecular Functionmetal ion binding
Molecular Functionprotein homodimerization activity
Biological Processcoumarin catabolic process
Biological Processestablishment of localization in cell
Biological Processnegative regulation of superoxide anion generation
Biological Processphenylacetate catabolic process
Biological Processrenal sodium ion transport
Biological Processresponse to toxic substance

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

Gene names

    • Name
      Pon3

Organism names

  • Taxonomic identifier
  • Strains
    • BALB/cJ
    • NOD
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q62087
  • Secondary accessions
    • Q4FZK0
    • Q8C2I7

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for signal, chain, disulfide bond, glycosylation, modified residue.

TypeIDPosition(s)Description
Signal1-?Not cleaved
ChainPRO_00002232911-354Serum paraoxonase/lactonase 3
Disulfide bond42↔352
Glycosylation50N-linked (GlcNAc...) asparagine
Modified residue165Phosphoserine
Glycosylation269N-linked (GlcNAc...) asparagine
Glycosylation323N-linked (GlcNAc...) asparagine

Post-translational modification

Glycosylated.
The signal sequence is not cleaved.

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Sequence similarities

Belongs to the paraoxonase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    354
  • Mass (Da)
    39,351
  • Last updated
    2004-07-19 v2
  • Checksum
    D66534EAA4EB10F2
MGKLVALTLLGACLALIGERLLNFRERVSTTREIKATEPQNCHLIEGLENGSEDIDILPSGLAFISTGLKYPGMPAFAPDKPGRIFLMDLNEQNPEAQALEISGGLDQESLNPHGISTFIDKDNTAYLYVVNHPNMDSTVEIFKFEEQQRSLIHLKTLKHELLKSVNDIVVLGPEQFYATRDHYFTSYFLVLLEMILDPHWTSVVFYSPKEVKVVAQGFSSANGITVSLDQKFVYVADVTAKNIHIMKKHDNWDLTPVKVIQLGTLVDNLTVDPATGDILAGCHPNPMKLLIYNPEDPPGSEVLRIQDSLSDKPRVSTLYANNGSVLQGSTVASVYHKRMLIGTIFHKALYCDL

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
D6RJ12D6RJ12_MOUSEPon374
H3BL07H3BL07_MOUSEPon3135

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict3in Ref. 1; AAC42090
Sequence conflict8in Ref. 1; AAC42090
Sequence conflict248in Ref. 1; AAC42090
Sequence conflict273in Ref. 1; AAC42090
Sequence conflict297in Ref. 1; AAC42090

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
L76193
EMBL· GenBank· DDBJ
AAC42090.1
EMBL· GenBank· DDBJ
mRNA
AK088572
EMBL· GenBank· DDBJ
BAC40430.1
EMBL· GenBank· DDBJ
mRNA
CH466533
EMBL· GenBank· DDBJ
EDL13970.1
EMBL· GenBank· DDBJ
Genomic DNA
BC099416
EMBL· GenBank· DDBJ
AAH99416.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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