Q61XX9 · RNC_CAEBR
- ProteinRibonuclease 3
- Genedrsh-1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids1061 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Executes the initial step of microRNA (miRNA) processing in the nucleus, that is the cleavage of pri-miRNA to release pre-miRNA. Involved in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in fertility. Required for the function or synthesis of the let-7 miRNA (By similarity).
Catalytic activity
Cofactor
Mn2+ (UniProtKB | Rhea| CHEBI:29035 )
Features
Showing features for binding site, site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | microprocessor complex | |
Cellular Component | nucleus | |
Molecular Function | metal ion binding | |
Molecular Function | ribonuclease III activity | |
Molecular Function | RNA binding | |
Biological Process | cell differentiation | |
Biological Process | gonadal mesoderm development | |
Biological Process | pre-miRNA processing | |
Biological Process | primary miRNA processing | |
Biological Process | rRNA processing | |
Biological Process | sexual reproduction |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameRibonuclease 3
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis
Accessions
- Primary accessionQ61XX9
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000309457 | 1-1061 | Ribonuclease 3 | |||
Sequence: MDFTEIHKRSRRKKFQQIHQDRKDEMIQQLGRRFHNQPSTSATYPSAVEDIPLPSEVPNVFGAPPPLTNADFHRNFLVDPDVVVSHSASLIRSNRHIVKAEDAEQYMMVSRERVGTTAERVLEDFNSRVIKPLKAKRRLQIDVPYIDHPLHSMRSKTPERKENEEDSDSEIRSSDSSSDAEYGSDVEEEPDSCRRKKRTHKIQKADSSQTKVEEKERQNTLLRMGIERKRNHPNAIDPHISYNEKGLGNDSPECRCPFPIRNRGLKHGYYAGENQVLKCSKNDRANLHYYTLHVTPAPNESQIQKTQMLINGMEYHFEGFTMVTHAPLPDCMTRRPVFKYSIDYEFQLIEEFMPTECFDPEDCNSIFEYIFHDIFELLDFDLYPKHLPPGTASCPTIHIVPRFVAMENNTTFIWSSKTVLAFFLLHGKNNMFSPEDVEKNCAMSDDAFGRTIAKLKQSIVLNPMKKPSALRADWFSRDLENKEMFLIQNTIRSQNFASPFLPQIAALEKKMSRLKQEKKDSGNKNPHYENLKAELIVLKDKHREARQLKLKLPVKDYIDTGLKPDVVAHVAMAIIASHHIRYNFSLSVFEKVIEYKFNDRRIVELALIHSSFRSYYGTTPDHVKNMISNCGYRKKYGAEERREKKKGIISLFNIMGGETSGGEPILHNERLEYLGDAVVELIASHHLFFILNHHFEGGLATYRTALVQNRNLAKLAMNCRIDEMLQFAHGADLINEAEWKHALANAFEALMAGVFLDSGIAPCDAIFSKAMYGKDPEMKKVWDHLNEHELKIEDPLGDRDLSRITPALTDFHRLEQIIGIEFNNIRLLAKAFTRRNVPFNDLTKGHNQRLEWLGDSVLQLIISDYLYRNFPLHHEGHMSLLRTSLVSNQTQSVVCDDLGFQEFVIKAPHRKNDLKMKDKADLVEAFIGALYVDKGLEYCRSFIRTVFCPRLKHFINSEKWNDAKSHLQQWCLAIRDSRNPNPAMPEYRLLGIQGPTNNRIFRVAVYFRGERLSSAAASNMHTAELKAAENALAALEKASFSRMREKYMSGRQHRLHRIFFS |
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-20 | Disordered | ||||
Sequence: MDFTEIHKRSRRKKFQQIHQ | ||||||
Region | 149-244 | Disordered | ||||
Sequence: PLHSMRSKTPERKENEEDSDSEIRSSDSSSDAEYGSDVEEEPDSCRRKKRTHKIQKADSSQTKVEEKERQNTLLRMGIERKRNHPNAIDPHISYNE | ||||||
Compositional bias | 152-175 | Basic and acidic residues | ||||
Sequence: SMRSKTPERKENEEDSDSEIRSSD | ||||||
Compositional bias | 203-235 | Basic and acidic residues | ||||
Sequence: QKADSSQTKVEEKERQNTLLRMGIERKRNHPNA | ||||||
Domain | 586-759 | RNase III 1 | ||||
Sequence: LSVFEKVIEYKFNDRRIVELALIHSSFRSYYGTTPDHVKNMISNCGYRKKYGAEERREKKKGIISLFNIMGGETSGGEPILHNERLEYLGDAVVELIASHHLFFILNHHFEGGLATYRTALVQNRNLAKLAMNCRIDEMLQFAHGADLINEAEWKHALANAFEALMAGVFLDSG | ||||||
Domain | 811-935 | RNase III 2 | ||||
Sequence: FHRLEQIIGIEFNNIRLLAKAFTRRNVPFNDLTKGHNQRLEWLGDSVLQLIISDYLYRNFPLHHEGHMSLLRTSLVSNQTQSVVCDDLGFQEFVIKAPHRKNDLKMKDKADLVEAFIGALYVDKG | ||||||
Domain | 962-1037 | DRBM | ||||
Sequence: DAKSHLQQWCLAIRDSRNPNPAMPEYRLLGIQGPTNNRIFRVAVYFRGERLSSAAASNMHTAELKAAENALAALEK |
Sequence similarities
Belongs to the ribonuclease III family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,061
- Mass (Da)122,481
- Last updated2004-11-23 v1
- Checksum796401EAD0B5138E
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 152-175 | Basic and acidic residues | ||||
Sequence: SMRSKTPERKENEEDSDSEIRSSD | ||||||
Compositional bias | 203-235 | Basic and acidic residues | ||||
Sequence: QKADSSQTKVEEKERQNTLLRMGIERKRNHPNA |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
HE600906 EMBL· GenBank· DDBJ | CAP24627.1 EMBL· GenBank· DDBJ | Genomic DNA |