Cloning and mapping of murine Nfe2l1.McKie J., Johnstone K., Mattei M.-G., Scambler P.View abstractCited forNUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)TissueEmbryoCategorySequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCGenomics 25:716-719 (1995)Cited in1Mapped to11
A novel splice variant of the transcription factor Nrf1 interacts with the TNFalpha promoter and stimulates transcription.Prieschl E.E., Novotny V., Csonga R., Jaksche D., Elbe-Buerger A., Thumb W., Auer M., Stingl G., Baumruker T.View abstractCited forNUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 3), FUNCTION, PHOSPHORYLATION BY CKIICategoriesFunction, PTM / Processing, SequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCNucleic Acids Res. 26:2291-2297 (1998)Cited in1
Lineage-specific biology revealed by a finished genome assembly of the mouse.Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L.[...], Ponting C.P.View abstractCited forNUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]StrainC57BL/6JCategorySequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCPLoS Biol. 7:E1000112-E1000112 (2009)Cited in99+99+
The bZIP transcription factor LCR-F1 is essential for mesoderm formation in mouse development.Farmer S.C., Sun C.W., Winnier G.E., Hogan B.L., Townes T.M.View abstractCited forDISRUPTION PHENOTYPECategoryPhenotypes & VariantsSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCGenes Dev. 11:786-798 (1997)Cited in1Mapped to15
Targeted disruption of the ubiquitous CNC-bZIP transcription factor, Nrf- 1, results in anemia and embryonic lethality in mice.Chan J.Y., Kwong M., Lu R., Chang J., Wang B., Yen T.S., Kan Y.W.View abstractCited forFUNCTION, DISRUPTION PHENOTYPECategoriesFunction, Phenotypes & VariantsSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCEMBO J. 17:1779-1787 (1998)Cited in1Mapped to11
The CNC basic leucine zipper factor, Nrf1, is essential for cell survival in response to oxidative stress-inducing agents. Role for Nrf1 in gamma- gcs(l) and gss expression in mouse fibroblasts.Kwong M., Kan Y.W., Chan J.Y.View abstractCited forFUNCTION, DNA-BINDINGCategoryFunctionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Biol. Chem. 274:37491-37498 (1999)Cited in1Mapped to11
TCF11/Nrf1 overexpression increases the intracellular glutathione level and can transactivate the gamma-glutamylcysteine synthetase (GCS) heavy subunit promoter.Myhrstad M.C., Husberg C., Murphy P., Nordstroem O., Blomhoff R., Moskaug J.O., Kolstoe A.B.View abstractCited forFUNCTION, DNA-BINDING, INTERACTION WITH MAFGCategoriesFunction, InteractionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCBiochim. Biophys. Acta 1517:212-219 (2001)Cited in1Mapped to13
Deficiency of the Nrf1 and Nrf2 transcription factors results in early embryonic lethality and severe oxidative stress.Leung L., Kwong M., Hou S., Lee C., Chan J.Y.View abstractCited forFUNCTION, DISRUPTION PHENOTYPECategoriesFunction, Phenotypes & VariantsSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Biol. Chem. 278:48021-48029 (2003)Cited in2Mapped to12
Nrf1 is critical for redox balance and survival of liver cells during development.Chen L., Kwong M., Lu R., Ginzinger D., Lee C., Leung L., Chan J.Y.View abstractCited forFUNCTIONCategoryFunctionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCMol. Cell. Biol. 23:4673-4686 (2003)Cited in1Mapped to25
Liver-specific inactivation of the Nrf1 gene in adult mouse leads to nonalcoholic steatohepatitis and hepatic neoplasia.Xu Z., Chen L., Leung L., Yen T.S., Lee C., Chan J.Y.View abstractCited forFUNCTION, DISRUPTION PHENOTYPECategoriesFunction, Phenotypes & VariantsSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCProc. Natl. Acad. Sci. U.S.A. 102:4120-4125 (2005)Cited in1Mapped to11
Negative regulation of the Nrf1 transcription factor by its N-terminal domain is independent of Keap1: Nrf1, but not Nrf2, is targeted to the endoplasmic reticulum.Zhang Y., Crouch D.H., Yamamoto M., Hayes J.D.View abstractCited forFUNCTION, SUBCELLULAR LOCATIONCategoriesFunction, Subcellular LocationSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCBiochem. J. 399:373-385 (2006)Cited in1Mapped to18
The NHB1 (N-terminal homology box 1) sequence in transcription factor Nrf1 is required to anchor it to the endoplasmic reticulum and also to enable its asparagine-glycosylation.Zhang Y., Lucocq J.M., Yamamoto M., Hayes J.D.View abstractCited forSUBCELLULAR LOCATION, GLYCOSYLATIONCategoriesPTM / Processing, Subcellular LocationSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCBiochem. J. 408:161-172 (2007)Cited in1Mapped to25
Nuclear factor-E2-related factor-1 mediates ascorbic acid induction of osterix expression via interaction with antioxidant-responsive element in bone cells.Xing W., Singgih A., Kapoor A., Alarcon C.M., Baylink D.J., Mohan S.View abstractCited forFUNCTIONCategoryFunctionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Biol. Chem. 282:22052-22061 (2007)Cited in2Mapped to11
Nrf1 and Nrf2 play distinct roles in activation of antioxidant response element-dependent genes.Ohtsuji M., Katsuoka F., Kobayashi A., Aburatani H., Hayes J.D., Yamamoto M.View abstractCited forFUNCTION, DISRUPTION PHENOTYPECategoriesFunction, Phenotypes & VariantsSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Biol. Chem. 283:33554-33562 (2008)Cited in1Mapped to32
The Nrf1 CNC/bZIP protein is a nuclear envelope-bound transcription factor that is activated by t-butyl hydroquinone but not by endoplasmic reticulum stressors.Zhang Y., Lucocq J.M., Hayes J.D.View abstractCited forSUBCELLULAR LOCATION, GLYCOSYLATION, SUBUNITCategoriesPTM / Processing, Interaction, Subcellular LocationSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCBiochem. J. 418:293-310 (2009)Cited in1Mapped to14
Identification of topological determinants in the N-terminal domain of transcription factor Nrf1 that control its orientation in the endoplasmic reticulum membrane.Zhang Y., Hayes J.D.View abstractCited forSUBCELLULAR LOCATION, TOPOLOGYCategorySubcellular LocationSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCBiochem. J. 430:497-510 (2010)Cited in1Mapped to6
Transcription factor Nrf1 mediates the proteasome recovery pathway after proteasome inhibition in mammalian cells.Radhakrishnan S.K., Lee C.S., Young P., Beskow A., Chan J.Y., Deshaies R.J.View abstractCited forFUNCTIONCategoryFunctionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCMol. Cell 38:17-28 (2010)Cited in1Mapped to31
Central nervous system-specific deletion of transcription factor Nrf1 causes progressive motor neuronal dysfunction.Kobayashi A., Tsukide T., Miyasaka T., Morita T., Mizoroki T., Saito Y., Ihara Y., Takashima A., Noguchi N.[...], Yamamoto M.View abstractCited forDISRUPTION PHENOTYPECategoryPhenotypes & VariantsSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCGenes Cells 16:692-703 (2011)Cited in1Mapped to25
The Fbw7 tumor suppressor regulates nuclear factor E2-related factor 1 transcription factor turnover through proteasome-mediated proteolysis.Biswas M., Phan D., Watanabe M., Chan J.Y.View abstractCited forUBIQUITINATION, INTERACTION WITH FBXW7, MUTAGENESIS OF 350-SER--GLU-354CategoriesPTM / Processing, Interaction, Phenotypes & VariantsSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Biol. Chem. 286:39282-39289 (2011)Cited in2Mapped to29
Dual regulation of the transcriptional activity of Nrf1 by beta-TrCP- and Hrd1-dependent degradation mechanisms.Tsuchiya Y., Morita T., Kim M., Iemura S., Natsume T., Yamamoto M., Kobayashi A.View abstractCited forFUNCTION, SUBCELLULAR LOCATION, UBIQUITINATION, INTERACTION WITH BTRC AND SYVN1, MUTAGENESIS OF 448-SER--SER-451CategoriesFunction, PTM / Processing, Interaction, Phenotypes & Variants, Subcellular LocationSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCMol. Cell. Biol. 31:4500-4512 (2011)Cited in3Mapped to36
Loss of nuclear factor E2-related factor 1 in the brain leads to dysregulation of proteasome gene expression and neurodegeneration.Lee C.S., Lee C., Hu T., Nguyen J.M., Zhang J., Martin M.V., Vawter M.P., Huang E.J., Chan J.Y.View abstractCited forFUNCTION, DISRUPTION PHENOTYPECategoriesFunction, Phenotypes & VariantsSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCProc. Natl. Acad. Sci. U.S.A. 108:8408-8413 (2011)Cited in1Mapped to25
NF-E2-related factor 1 (Nrf1) serves as a novel regulator of hepatic lipid metabolism through regulation of the Lipin1 and PGC-1beta genes.Hirotsu Y., Hataya N., Katsuoka F., Yamamoto M.View abstractCited forFUNCTIONCategoryFunctionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCMol. Cell. Biol. 32:2760-2770 (2012)Cited in1Mapped to44
Characterization of Nrf1b, a novel isoform of the nuclear factor- erythroid-2 related transcription factor-1 that activates antioxidant response element-regulated genes.Kwong E.K., Kim K.M., Penalosa P.J., Chan J.Y.View abstractCited forALTERNATIVE PROMOTER USAGE, IDENTIFICATION OF ISOFORM 2, FUNCTION, INTERACTION WITH MAFG, SUBCELLULAR LOCATION, TISSUE SPECIFICITYCategoriesFunction, Sequences, Expression, Interaction, Subcellular LocationSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCPLoS ONE 7:E48404-E48404 (2012)Cited in1Mapped to31
The casein kinase 2-nrf1 axis controls the clearance of ubiquitinated proteins by regulating proteasome gene expression.Tsuchiya Y., Taniguchi H., Ito Y., Morita T., Karim M.R., Ohtake N., Fukagai K., Ito T., Okamuro S.[...], Kobayashi A.View abstractCited forFUNCTION, PHOSPHORYLATION AT SER-497, MUTAGENESIS OF SER-496; SER-497; SER-499 AND THR-501CategoriesFunction, PTM / Processing, Phenotypes & VariantsSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCMol. Cell. Biol. 33:3461-3472 (2013)Cited in1Mapped to30
Transcription factor NF-E2-related factor 1 impairs glucose metabolism in mice.Hirotsu Y., Higashi C., Fukutomi T., Katsuoka F., Tsujita T., Yagishita Y., Matsuyama Y., Motohashi H., Uruno A., Yamamoto M.View abstractCited forFUNCTIONCategoryFunctionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCGenes Cells 19:650-665 (2014)Cited in1Mapped to25