Q61789 · LAMA3_MOUSE
- ProteinLaminin subunit alpha-3
- GeneLama3
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids3330 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
Laminin-5 is thought to be involved in 1 cell adhesion via integrin alpha-3/beta-1 in focal adhesion and integrin alpha-6/beta-4 in hemidesmosomes, 2 signal transduction via tyrosine phosphorylation of pp125-FAK and p80, 3 differentiation of keratinocytes.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | adherens junction | |
Cellular Component | basement membrane | |
Cellular Component | collagen-containing extracellular matrix | |
Cellular Component | endoplasmic reticulum | |
Cellular Component | extracellular region | |
Cellular Component | hemidesmosome | |
Cellular Component | laminin-3 complex | |
Cellular Component | laminin-5 complex | |
Molecular Function | extracellular matrix structural constituent | |
Molecular Function | signaling receptor binding | |
Biological Process | animal organ morphogenesis | |
Biological Process | axon guidance | |
Biological Process | cell-cell adhesion | |
Biological Process | endodermal cell differentiation | |
Biological Process | hemidesmosome assembly | |
Biological Process | regulation of cell adhesion | |
Biological Process | regulation of cell migration | |
Biological Process | regulation of embryonic development | |
Biological Process | tissue development |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameLaminin subunit alpha-3
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ61789
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: Major component.
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, glycosylation, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-31 | |||||
Sequence: MAVALGRAPRSLPLLLTLLLLLLLRMSPSWS | ||||||
Chain | PRO_0000017059 | 32-3330 | Laminin subunit alpha-3 | |||
Sequence: VVGQDHPMSSRSLHPPYFNLAQAARIWATATCGERDPEVSRPRPELFCKLVGGPAAQGSGHTIQGQFCDYCNSEDSRKAHPASHAIDGSERWWQSPPLSSGTQYNQVNLTLDLGQLFHVAYILIKFANSPRPDLWILERSVDFGSTYSPWQYFAHSRRDCVEQFGQEANMAITQDDQMLCVTEYSRIVPLENGEIVVSLINGRPGAKKFAFSDTLREFTKATNIRLRFLRTNTLLGHLISKAERDPTVTRRYYYSIKDISVGGRCVCNGHAEACSADNPEKQFRCECQHHTCGDTCNRCCAGYNQRRWQPAGQEQHNECEACNCHGHAVDCYYDPDVEHQQASLNSKGVYAGGGVCINCQHNTAGVNCEKCAKGYFRPHGVPVDALHGCIPCSCDPERADDCDQGSGHCHCKPNFSGDYCETCADGYYNFPFCLRIPVFPNYTPSPEDPVAGNIKGCDCNLEGVLPEICDDRGRCLCRPGVEGPQCDSCRSGSYSFPICQACQCSTIGSYPVPCDPGNGQCDCLPGITGRQCDRCLSGAYDFPYCQGSGSVCHPAGTLDSSLGYCQCKQHVASPTCSVCKPLYWNLAKENPRGCSECQCHEAGTLSGIGECGQEDGDCSCKAHVTGDACDTCEDGFFSLEKSNYFGCQGCQCDIGGALTTMCSGPSGVCQCREHVEGKQCQRPENNYYFPDLHHMKYEVEDGTGPNGRNLRFGFDPLVFPEFSWRGYAPMTSVQNEVRVRLSVRQSSLSLFRIVLRYISPGTEAISGRITLYSSQGDSDALQSRKITFPPSKEPAFVTVPGNGFAGPFSITPGTWIACIQVEGVLLDYLVLLPRDYYEAFTLQVPVTEPCAHTGSPQDNCLLYQHLPLTAFSCTLACEARHFLLDGELRPLAMRQPTPTHPAMVDLSGREVELQLRLRVPQVGHYVVLLEYATEVEQLFVVDVNLKSSGSALAGQVNIYSCKYSIPCRSVVIDSLSRTAVHELLADADIQLKAHMAHFLLYHICIIPAEEFSTEYLRPQVHCIASYRQHANPSASCVSLAHETPPTASILDATSRGLFSALPHEPSSPADGVTLKAPQSQVTLKGLIPHLGRHVFVIHFYQAEHPGFPTEVIVNGGRQWSGSFLASFCPHLLGCRDQVISDGQVEFDISEAEVAVTVKIPDGKSLTLVRVLVVPAENYDYQILHKTTVDKSSEFISSCGGDSFYIDPQAASGFCKNSARSLVAFYHNGAIPCECDPAGTAGHHCSPEGGQCPCRPNVIGRQCSRCATGYYGFPYCKPCNCGRRLCEEVTGKCLCPPHTVRPQCEVCEMNSFNFHPVAGCDVCNCSRKGTIEAAVSECDRDSGQCRCKPRVTGQQCDKCAPGFYQFPECVPCSCNRDGTEPSVCDPETGACMCKENVEGPQCQLCREGSFYLDPTNPKGCTKCFCFGVNTDCQSSHKQRAKFVDMMGWRLETADGVDVPVSFNPGSNSMVADLQELPPSVHSASWVAPPSYLGDKVSSYGGYLTYHAKSFGLPGDMVLLGKQPDVQLTGQHMSLIHKEPSDPRPDRLHHGRVQVIEGNFRHEGSSAPVSREELMTVLSRLERLHIRGLHFTETQRLTLGEVGLEEASDTGSGPRAHLVEMCACPPDYTGDSCQGCRPGYYWDNKSLPVGRCVPCNCNGHSNRCQDGSGICINCQHNTAGEHCERCQAGHYGNAIHGSCRVCPCPHTNSFATGCAVDGGAVRCACKPGYTGTQCERCAPGYFGNPQKFGGSCQPCNCNSNGQLGPCDPLTGDCVNQEPKDGSPAEECDDCDSCVMTLLNDLASMGEELRLVKSKLQGLSVSTGALEQIRHMETQAKDLRNQLLGFRSATSSHGSKMDDLEKELSHLNREFETLQEKAQVNSRKAQTLYNNIDQTIQSAKELDMKIKNIVQNVHILLKQMARPGGEGTDLPVGDWSRELAEAQRMMRDLRSRDFKKHLQEAEAEKMEAQLLLHRIRTWLESHQVENNGLLKNIRDSLNDYEDKLQDLRSILQEAAAQAKQATGINHENEGVLGAIQRQMKEMDSLKNDFTKYLATADSSLLQTNNLLQQMDKSQKEYESLAAALNGARQELSDRVRELSRSGGKAPLVVEAEKHAQSLQELAKQLEEIKRNTSGDELVRCAVDAATAYENILNAIRAAEDAASKATSASKSAFQTVIKEDLPKRAKTLSSDSEELLNEAKMTQKRLQQVSPALNSLQQTLKTVSVQKDLLDANLTVARDDLHGIQRGDIDSVVIGAKSMVREANGITSEVLDGLNPIQTDLGRIKDSYESARREDFSKALVDANNSVKKLTRKLPDLFIKIESINQQLLPLGNISDNVDRIRELIQQARDAANKVAIPMRFNGKSGVEVRLPNDLEDLKGYTSLSLFLQRPDLRENGGTEDMFVMYLGNKDASKDYIGMAVVDGQLTCVYNLGDREAEVQIDQVLTESESQEAVMDRVKFQRIYQFAKLNYTKEATSTKPKAPGVYDMESASSNTLLNLDPENAVFYVGGYPPGFELPRRLRFPPYKGCIELDDLNENVLSLYNFKTTFNLNTTEVEPCRRRKEESDKNYFEGTGYARIPTQPNAPFPNFMQTIQTTVDRGLLFFAENQDNFISLNIEDGNLMVKYKLNSEPPKEKGIRDTINNGRDHMILISIGKSQKRMLINMNKHSIIIEGEIFDFSTYYLGGIPIAIRERFNISTPAFQGCMKNLKKTSGVVRLNDTVGVTKKCSEDWKLVRTASFSRGGQMSFTNLDVPSLDRFQLSFGFQTFQPSGTLLNHQTRTSSLLVTLEDGHIALSTRDSSSPIFKSPGTYMDGLLHHVSVISDTSGLRLLIDDQVLRRNQRLASFSNAQQSLSMGGGYFEGCISNVFVQRMSQSPEVLDMASKSTKRDAFLGGCSLNKPPFLMLFKSPKGFNKARSFNVNQLLQDAPQAARSIEAWQDGKSCLPPLNTKATHRALQFGDSPTSHLLFKLPQELLKPRLQFSLDIQTTSSRGLVFHTGTRDSFVALYLSEGHVIFALGAGGKKLRLRSKERYHDGKWHSVVFGLSGRKVHLVVDGLRAQEGSLPGNSTISPREQVYLGLSPSRKSKSLPQHSFVGCLRNFQLDSKPLDSPSARSGVSPCLGGSLEKGIYFSQGGGHVVLANSVSLEPALTLTLSIRPRSLTGVLIHIASQSGEHLSVYMEAGKVTTSMNSEAGGTVTSITPKRSLCDGQWHSVTVSIKQHTLHLELDTDNSYTAGQLSFPPNSTRGSLHIGGVPDKLKMLTLPVWNSFFGCLKNIQVNHIPVPITEATDVQGSVSLNGCPDH | ||||||
Glycosylation | 139 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 296↔305 | |||||
Sequence: CVCNGHAEAC | ||||||
Disulfide bond | 298↔316 | |||||
Sequence: CNGHAEACSADNPEKQFRC | ||||||
Disulfide bond | 318↔327 | |||||
Sequence: CQHHTCGDTC | ||||||
Disulfide bond | 330↔350 | |||||
Sequence: CCAGYNQRRWQPAGQEQHNEC | ||||||
Disulfide bond | 353↔362 | |||||
Sequence: CNCHGHAVDC | ||||||
Disulfide bond | 355↔387 | |||||
Sequence: CHGHAVDCYYDPDVEHQQASLNSKGVYAGGGVC | ||||||
Disulfide bond | 390↔399 | |||||
Sequence: CQHNTAGVNC | ||||||
Disulfide bond | 402↔420 | |||||
Sequence: CAKGYFRPHGVPVDALHGC | ||||||
Disulfide bond | 423↔433 | |||||
Sequence: CSCDPERADDC | ||||||
Disulfide bond | 425↔440 | |||||
Sequence: CDPERADDCDQGSGHC | ||||||
Disulfide bond | 442↔451 | |||||
Sequence: CKPNFSGDYC | ||||||
Glycosylation | 445 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 454↔464 | |||||
Sequence: CADGYYNFPFC | ||||||
Disulfide bond | 488↔500 | |||||
Sequence: CDCNLEGVLPEIC | ||||||
Disulfide bond | 490↔506 | |||||
Sequence: CNLEGVLPEICDDRGRC | ||||||
Disulfide bond | 508↔517 | |||||
Sequence: CRPGVEGPQC | ||||||
Disulfide bond | 520↔530 | |||||
Sequence: CRSGSYSFPIC | ||||||
Disulfide bond | 533↔545 | |||||
Sequence: CQCSTIGSYPVPC | ||||||
Disulfide bond | 535↔552 | |||||
Sequence: CSTIGSYPVPCDPGNGQC | ||||||
Disulfide bond | 554↔563 | |||||
Sequence: CLPGITGRQC | ||||||
Disulfide bond | 566↔583 | |||||
Sequence: CLSGAYDFPYCQGSGSVC | ||||||
Disulfide bond | 628↔642 | |||||
Sequence: CQCHEAGTLSGIGEC | ||||||
Disulfide bond | 630↔649 | |||||
Sequence: CHEAGTLSGIGECGQEDGDC | ||||||
Disulfide bond | 651↔660 | |||||
Sequence: CKAHVTGDAC | ||||||
Disulfide bond | 663↔678 | |||||
Sequence: CEDGFFSLEKSNYFGC | ||||||
Disulfide bond | 681↔693 | |||||
Sequence: CQCDIGGALTTMC | ||||||
Disulfide bond | 683↔700 | |||||
Sequence: CDIGGALTTMCSGPSGVC | ||||||
Disulfide bond | 702↔711 | |||||
Sequence: CREHVEGKQC | ||||||
Disulfide bond | 1309↔1316 | |||||
Sequence: CNCGRRLC | ||||||
Disulfide bond | 1311↔1323 | |||||
Sequence: CGRRLCEEVTGKC | ||||||
Disulfide bond | 1325↔1334 | |||||
Sequence: CPPHTVRPQC | ||||||
Disulfide bond | 1337↔1350 | |||||
Sequence: CEMNSFNFHPVAGC | ||||||
Disulfide bond | 1353↔1368 | |||||
Sequence: CNCSRKGTIEAAVSEC | ||||||
Glycosylation | 1354 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 1355↔1375 | |||||
Sequence: CSRKGTIEAAVSECDRDSGQC | ||||||
Disulfide bond | 1377↔1386 | |||||
Sequence: CKPRVTGQQC | ||||||
Disulfide bond | 1389↔1399 | |||||
Sequence: CAPGFYQFPEC | ||||||
Disulfide bond | 1402↔1414 | |||||
Sequence: CSCNRDGTEPSVC | ||||||
Disulfide bond | 1404↔1421 | |||||
Sequence: CNRDGTEPSVCDPETGAC | ||||||
Disulfide bond | 1423↔1432 | |||||
Sequence: CKENVEGPQC | ||||||
Disulfide bond | 1435↔1450 | |||||
Sequence: CREGSFYLDPTNPKGC | ||||||
Glycosylation | 1673 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 1684↔1693 | |||||
Sequence: CNCNGHSNRC | ||||||
Disulfide bond | 1686↔1700 | |||||
Sequence: CNGHSNRCQDGSGIC | ||||||
Disulfide bond | 1703↔1712 | |||||
Sequence: CQHNTAGEHC | ||||||
Disulfide bond | 1715↔1728 | |||||
Sequence: CQAGHYGNAIHGSC | ||||||
Disulfide bond | 1731↔1743 | |||||
Sequence: CPCPHTNSFATGC | ||||||
Disulfide bond | 1733↔1752 | |||||
Sequence: CPHTNSFATGCAVDGGAVRC | ||||||
Disulfide bond | 1754↔1763 | |||||
Sequence: CKPGYTGTQC | ||||||
Disulfide bond | 1766↔1781 | |||||
Sequence: CAPGYFGNPQKFGGSC | ||||||
Disulfide bond | 1819 | Interchain | ||||
Sequence: C | ||||||
Disulfide bond | 1822 | Interchain | ||||
Sequence: C | ||||||
Glycosylation | 2159 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 2261 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 2332 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 2361 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 2498 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 2557↔2587 | |||||
Sequence: CIELDDLNENVLSLYNFKTTFNLNTTEVEPC | ||||||
Glycosylation | 2580 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 2733↔2756 | |||||
Sequence: CMKNLKKTSGVVRLNDTVGVTKKC | ||||||
Glycosylation | 2747 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 2891↔2923 | |||||
Sequence: CISNVFVQRMSQSPEVLDMASKSTKRDAFLGGC | ||||||
Glycosylation | 3094 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 3124↔3147 | |||||
Sequence: CLRNFQLDSKPLDSPSARSGVSPC | ||||||
Glycosylation | 3270 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 3299↔3327 | |||||
Sequence: CLKNIQVNHIPVPITEATDVQGSVSLNGC |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Basal membrane of the upper alimentary tract and urinary and nasal epithelia, salivary glands and teeth (both variants). Isoform A is predominantly expressed in skin, hair follicles and developing neurons of the trigeminal ganglion. Isoform B was found in bronchi, alveoli, stomach, intestinal crypts, whisker pads, CNS, telencephalic neuroectoderm, thalamus, Rathke pouch and periventricular subependymal germinal layer.
Gene expression databases
Interaction
Subunit
Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Alpha-3 is a subunit of laminin-5 (laminin-332 or epiligrin/kalinin/nicein), laminin-6 (laminin-311 or K-laminin) and laminin-7 (laminin-321 or KS-laminin).
Protein-protein interaction databases
Miscellaneous
Family & Domains
Features
Showing features for domain, region, coiled coil, motif.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 40-295 | Laminin N-terminal | ||||
Sequence: SSRSLHPPYFNLAQAARIWATATCGERDPEVSRPRPELFCKLVGGPAAQGSGHTIQGQFCDYCNSEDSRKAHPASHAIDGSERWWQSPPLSSGTQYNQVNLTLDLGQLFHVAYILIKFANSPRPDLWILERSVDFGSTYSPWQYFAHSRRDCVEQFGQEANMAITQDDQMLCVTEYSRIVPLENGEIVVSLINGRPGAKKFAFSDTLREFTKATNIRLRFLRTNTLLGHLISKAERDPTVTRRYYYSIKDISVGGR | ||||||
Region | 295-725 | Domain V | ||||
Sequence: RCVCNGHAEACSADNPEKQFRCECQHHTCGDTCNRCCAGYNQRRWQPAGQEQHNECEACNCHGHAVDCYYDPDVEHQQASLNSKGVYAGGGVCINCQHNTAGVNCEKCAKGYFRPHGVPVDALHGCIPCSCDPERADDCDQGSGHCHCKPNFSGDYCETCADGYYNFPFCLRIPVFPNYTPSPEDPVAGNIKGCDCNLEGVLPEICDDRGRCLCRPGVEGPQCDSCRSGSYSFPICQACQCSTIGSYPVPCDPGNGQCDCLPGITGRQCDRCLSGAYDFPYCQGSGSVCHPAGTLDSSLGYCQCKQHVASPTCSVCKPLYWNLAKENPRGCSECQCHEAGTLSGIGECGQEDGDCSCKAHVTGDACDTCEDGFFSLEKSNYFGCQGCQCDIGGALTTMCSGPSGVCQCREHVEGKQCQRPENNYYFPDLHH | ||||||
Domain | 296-350 | Laminin EGF-like 1 | ||||
Sequence: CVCNGHAEACSADNPEKQFRCECQHHTCGDTCNRCCAGYNQRRWQPAGQEQHNEC | ||||||
Domain | 353-420 | Laminin EGF-like 2 | ||||
Sequence: CNCHGHAVDCYYDPDVEHQQASLNSKGVYAGGGVCINCQHNTAGVNCEKCAKGYFRPHGVPVDALHGC | ||||||
Domain | 423-464 | Laminin EGF-like 3 | ||||
Sequence: CSCDPERADDCDQGSGHCHCKPNFSGDYCETCADGYYNFPFC | ||||||
Domain | 488-530 | Laminin EGF-like 4 | ||||
Sequence: CDCNLEGVLPEICDDRGRCLCRPGVEGPQCDSCRSGSYSFPIC | ||||||
Domain | 533-576 | Laminin EGF-like 5 | ||||
Sequence: CQCSTIGSYPVPCDPGNGQCDCLPGITGRQCDRCLSGAYDFPYC | ||||||
Domain | 582-625 | Laminin EGF-like 6 | ||||
Sequence: VCHPAGTLDSSLGYCQCKQHVASPTCSVCKPLYWNLAKENPRGC | ||||||
Domain | 628-678 | Laminin EGF-like 7 | ||||
Sequence: CQCHEAGTLSGIGECGQEDGDCSCKAHVTGDACDTCEDGFFSLEKSNYFGC | ||||||
Domain | 681-725 | Laminin EGF-like 8 | ||||
Sequence: CQCDIGGALTTMCSGPSGVCQCREHVEGKQCQRPENNYYFPDLHH | ||||||
Region | 793-1262 | Domain IV 1 (domain IV B) | ||||
Sequence: TEAISGRITLYSSQGDSDALQSRKITFPPSKEPAFVTVPGNGFAGPFSITPGTWIACIQVEGVLLDYLVLLPRDYYEAFTLQVPVTEPCAHTGSPQDNCLLYQHLPLTAFSCTLACEARHFLLDGELRPLAMRQPTPTHPAMVDLSGREVELQLRLRVPQVGHYVVLLEYATEVEQLFVVDVNLKSSGSALAGQVNIYSCKYSIPCRSVVIDSLSRTAVHELLADADIQLKAHMAHFLLYHICIIPAEEFSTEYLRPQVHCIASYRQHANPSASCVSLAHETPPTASILDATSRGLFSALPHEPSSPADGVTLKAPQSQVTLKGLIPHLGRHVFVIHFYQAEHPGFPTEVIVNGGRQWSGSFLASFCPHLLGCRDQVISDGQVEFDISEAEVAVTVKIPDGKSLTLVRVLVVPAENYDYQILHKTTVDKSSEFISSCGGDSFYIDPQAASGFCKNSARSLVAFYHNGAIP | ||||||
Region | 1263-1462 | Domain III B | ||||
Sequence: CECDPAGTAGHHCSPEGGQCPCRPNVIGRQCSRCATGYYGFPYCKPCNCGRRLCEEVTGKCLCPPHTVRPQCEVCEMNSFNFHPVAGCDVCNCSRKGTIEAAVSECDRDSGQCRCKPRVTGQQCDKCAPGFYQFPECVPCSCNRDGTEPSVCDPETGACMCKENVEGPQCQLCREGSFYLDPTNPKGCTKCFCFGVNTDC | ||||||
Domain | 1309-1352 | Laminin EGF-like 9 | ||||
Sequence: CNCGRRLCEEVTGKCLCPPHTVRPQCEVCEMNSFNFHPVAGCDV | ||||||
Domain | 1353-1401 | Laminin EGF-like 10 | ||||
Sequence: CNCSRKGTIEAAVSECDRDSGQCRCKPRVTGQQCDKCAPGFYQFPECVP | ||||||
Domain | 1402-1452 | Laminin EGF-like 11 | ||||
Sequence: CSCNRDGTEPSVCDPETGACMCKENVEGPQCQLCREGSFYLDPTNPKGCTK | ||||||
Domain | 1453-1462 | Laminin EGF-like 12; first part | ||||
Sequence: CFCFGVNTDC | ||||||
Domain | 1466-1650 | Laminin IV type A | ||||
Sequence: HKQRAKFVDMMGWRLETADGVDVPVSFNPGSNSMVADLQELPPSVHSASWVAPPSYLGDKVSSYGGYLTYHAKSFGLPGDMVLLGKQPDVQLTGQHMSLIHKEPSDPRPDRLHHGRVQVIEGNFRHEGSSAPVSREELMTVLSRLERLHIRGLHFTETQRLTLGEVGLEEASDTGSGPRAHLVEM | ||||||
Domain | 1651-1683 | Laminin EGF-like 12; second part | ||||
Sequence: CACPPDYTGDSCQGCRPGYYWDNKSLPVGRCVP | ||||||
Region | 1651-1818 | Domain III A | ||||
Sequence: CACPPDYTGDSCQGCRPGYYWDNKSLPVGRCVPCNCNGHSNRCQDGSGICINCQHNTAGEHCERCQAGHYGNAIHGSCRVCPCPHTNSFATGCAVDGGAVRCACKPGYTGTQCERCAPGYFGNPQKFGGSCQPCNCNSNGQLGPCDPLTGDCVNQEPKDGSPAEECDD | ||||||
Domain | 1684-1730 | Laminin EGF-like 13 | ||||
Sequence: CNCNGHSNRCQDGSGICINCQHNTAGEHCERCQAGHYGNAIHGSCRV | ||||||
Domain | 1731-1783 | Laminin EGF-like 14 | ||||
Sequence: CPCPHTNSFATGCAVDGGAVRCACKPGYTGTQCERCAPGYFGNPQKFGGSCQP | ||||||
Domain | 1784-1818 | Laminin EGF-like 15; truncated | ||||
Sequence: CNCNSNGQLGPCDPLTGDCVNQEPKDGSPAEECDD | ||||||
Region | 1819-2385 | Domain II and I | ||||
Sequence: CDSCVMTLLNDLASMGEELRLVKSKLQGLSVSTGALEQIRHMETQAKDLRNQLLGFRSATSSHGSKMDDLEKELSHLNREFETLQEKAQVNSRKAQTLYNNIDQTIQSAKELDMKIKNIVQNVHILLKQMARPGGEGTDLPVGDWSRELAEAQRMMRDLRSRDFKKHLQEAEAEKMEAQLLLHRIRTWLESHQVENNGLLKNIRDSLNDYEDKLQDLRSILQEAAAQAKQATGINHENEGVLGAIQRQMKEMDSLKNDFTKYLATADSSLLQTNNLLQQMDKSQKEYESLAAALNGARQELSDRVRELSRSGGKAPLVVEAEKHAQSLQELAKQLEEIKRNTSGDELVRCAVDAATAYENILNAIRAAEDAASKATSASKSAFQTVIKEDLPKRAKTLSSDSEELLNEAKMTQKRLQQVSPALNSLQQTLKTVSVQKDLLDANLTVARDDLHGIQRGDIDSVVIGAKSMVREANGITSEVLDGLNPIQTDLGRIKDSYESARREDFSKALVDANNSVKKLTRKLPDLFIKIESINQQLLPLGNISDNVDRIRELIQQARDAANKVAI | ||||||
Coiled coil | 1851-1980 | |||||
Sequence: TGALEQIRHMETQAKDLRNQLLGFRSATSSHGSKMDDLEKELSHLNREFETLQEKAQVNSRKAQTLYNNIDQTIQSAKELDMKIKNIVQNVHILLKQMARPGGEGTDLPVGDWSRELAEAQRMMRDLRSR | ||||||
Coiled coil | 2012-2057 | |||||
Sequence: VENNGLLKNIRDSLNDYEDKLQDLRSILQEAAAQAKQATGINHENE | ||||||
Coiled coil | 2088-2165 | |||||
Sequence: LLQTNNLLQQMDKSQKEYESLAAALNGARQELSDRVRELSRSGGKAPLVVEAEKHAQSLQELAKQLEEIKRNTSGDEL | ||||||
Coiled coil | 2211-2238 | |||||
Sequence: KRAKTLSSDSEELLNEAKMTQKRLQQVS | ||||||
Motif | 2274-2276 | Cell attachment site | ||||
Sequence: RGD | ||||||
Coiled coil | 2318-2383 | |||||
Sequence: SARREDFSKALVDANNSVKKLTRKLPDLFIKIESINQQLLPLGNISDNVDRIRELIQQARDAANKV | ||||||
Domain | 2386-2587 | Laminin G-like 1 | ||||
Sequence: PMRFNGKSGVEVRLPNDLEDLKGYTSLSLFLQRPDLRENGGTEDMFVMYLGNKDASKDYIGMAVVDGQLTCVYNLGDREAEVQIDQVLTESESQEAVMDRVKFQRIYQFAKLNYTKEATSTKPKAPGVYDMESASSNTLLNLDPENAVFYVGGYPPGFELPRRLRFPPYKGCIELDDLNENVLSLYNFKTTFNLNTTEVEPC | ||||||
Domain | 2594-2756 | Laminin G-like 2 | ||||
Sequence: SDKNYFEGTGYARIPTQPNAPFPNFMQTIQTTVDRGLLFFAENQDNFISLNIEDGNLMVKYKLNSEPPKEKGIRDTINNGRDHMILISIGKSQKRMLINMNKHSIIIEGEIFDFSTYYLGGIPIAIRERFNISTPAFQGCMKNLKKTSGVVRLNDTVGVTKKC | ||||||
Domain | 2763-2923 | Laminin G-like 3 | ||||
Sequence: VRTASFSRGGQMSFTNLDVPSLDRFQLSFGFQTFQPSGTLLNHQTRTSSLLVTLEDGHIALSTRDSSSPIFKSPGTYMDGLLHHVSVISDTSGLRLLIDDQVLRRNQRLASFSNAQQSLSMGGGYFEGCISNVFVQRMSQSPEVLDMASKSTKRDAFLGGC | ||||||
Domain | 2983-3147 | Laminin G-like 4 | ||||
Sequence: ALQFGDSPTSHLLFKLPQELLKPRLQFSLDIQTTSSRGLVFHTGTRDSFVALYLSEGHVIFALGAGGKKLRLRSKERYHDGKWHSVVFGLSGRKVHLVVDGLRAQEGSLPGNSTISPREQVYLGLSPSRKSKSLPQHSFVGCLRNFQLDSKPLDSPSARSGVSPC | ||||||
Domain | 3154-3327 | Laminin G-like 5 | ||||
Sequence: KGIYFSQGGGHVVLANSVSLEPALTLTLSIRPRSLTGVLIHIASQSGEHLSVYMEAGKVTTSMNSEAGGTVTSITPKRSLCDGQWHSVTVSIKQHTLHLELDTDNSYTAGQLSFPPNSTRGSLHIGGVPDKLKMLTLPVWNSFFGCLKNIQVNHIPVPITEATDVQGSVSLNGC |
Domain
The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure.
Domains IV and G are globular.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
This entry describes 2 isoforms produced by Alternative splicing.
Q61789-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- NameB
- Length3,330
- Mass (Da)366,227
- Last updated2013-10-16 v4
- Checksum993EB20BACDD6C59
MAVALGRAPRSLPLLLTLLLLLLLRMSPSWSVVGQDHPMSSRSLHPPYFNLAQAARIWATATCGERDPEVSRPRPELFCKLVGGPAAQGSGHTIQGQFCDYCNSEDSRKAHPASHAIDGSERWWQSPPLSSGTQYNQVNLTLDLGQLFHVAYILIKFANSPRPDLWILERSVDFGSTYSPWQYFAHSRRDCVEQFGQEANMAITQDDQMLCVTEYSRIVPLENGEIVVSLINGRPGAKKFAFSDTLREFTKATNIRLRFLRTNTLLGHLISKAERDPTVTRRYYYSIKDISVGGRCVCNGHAEACSADNPEKQFRCECQHHTCGDTCNRCCAGYNQRRWQPAGQEQHNECEACNCHGHAVDCYYDPDVEHQQASLNSKGVYAGGGVCINCQHNTAGVNCEKCAKGYFRPHGVPVDALHGCIPCSCDPERADDCDQGSGHCHCKPNFSGDYCETCADGYYNFPFCLRIPVFPNYTPSPEDPVAGNIKGCDCNLEGVLPEICDDRGRCLCRPGVEGPQCDSCRSGSYSFPICQACQCSTIGSYPVPCDPGNGQCDCLPGITGRQCDRCLSGAYDFPYCQGSGSVCHPAGTLDSSLGYCQCKQHVASPTCSVCKPLYWNLAKENPRGCSECQCHEAGTLSGIGECGQEDGDCSCKAHVTGDACDTCEDGFFSLEKSNYFGCQGCQCDIGGALTTMCSGPSGVCQCREHVEGKQCQRPENNYYFPDLHHMKYEVEDGTGPNGRNLRFGFDPLVFPEFSWRGYAPMTSVQNEVRVRLSVRQSSLSLFRIVLRYISPGTEAISGRITLYSSQGDSDALQSRKITFPPSKEPAFVTVPGNGFAGPFSITPGTWIACIQVEGVLLDYLVLLPRDYYEAFTLQVPVTEPCAHTGSPQDNCLLYQHLPLTAFSCTLACEARHFLLDGELRPLAMRQPTPTHPAMVDLSGREVELQLRLRVPQVGHYVVLLEYATEVEQLFVVDVNLKSSGSALAGQVNIYSCKYSIPCRSVVIDSLSRTAVHELLADADIQLKAHMAHFLLYHICIIPAEEFSTEYLRPQVHCIASYRQHANPSASCVSLAHETPPTASILDATSRGLFSALPHEPSSPADGVTLKAPQSQVTLKGLIPHLGRHVFVIHFYQAEHPGFPTEVIVNGGRQWSGSFLASFCPHLLGCRDQVISDGQVEFDISEAEVAVTVKIPDGKSLTLVRVLVVPAENYDYQILHKTTVDKSSEFISSCGGDSFYIDPQAASGFCKNSARSLVAFYHNGAIPCECDPAGTAGHHCSPEGGQCPCRPNVIGRQCSRCATGYYGFPYCKPCNCGRRLCEEVTGKCLCPPHTVRPQCEVCEMNSFNFHPVAGCDVCNCSRKGTIEAAVSECDRDSGQCRCKPRVTGQQCDKCAPGFYQFPECVPCSCNRDGTEPSVCDPETGACMCKENVEGPQCQLCREGSFYLDPTNPKGCTKCFCFGVNTDCQSSHKQRAKFVDMMGWRLETADGVDVPVSFNPGSNSMVADLQELPPSVHSASWVAPPSYLGDKVSSYGGYLTYHAKSFGLPGDMVLLGKQPDVQLTGQHMSLIHKEPSDPRPDRLHHGRVQVIEGNFRHEGSSAPVSREELMTVLSRLERLHIRGLHFTETQRLTLGEVGLEEASDTGSGPRAHLVEMCACPPDYTGDSCQGCRPGYYWDNKSLPVGRCVPCNCNGHSNRCQDGSGICINCQHNTAGEHCERCQAGHYGNAIHGSCRVCPCPHTNSFATGCAVDGGAVRCACKPGYTGTQCERCAPGYFGNPQKFGGSCQPCNCNSNGQLGPCDPLTGDCVNQEPKDGSPAEECDDCDSCVMTLLNDLASMGEELRLVKSKLQGLSVSTGALEQIRHMETQAKDLRNQLLGFRSATSSHGSKMDDLEKELSHLNREFETLQEKAQVNSRKAQTLYNNIDQTIQSAKELDMKIKNIVQNVHILLKQMARPGGEGTDLPVGDWSRELAEAQRMMRDLRSRDFKKHLQEAEAEKMEAQLLLHRIRTWLESHQVENNGLLKNIRDSLNDYEDKLQDLRSILQEAAAQAKQATGINHENEGVLGAIQRQMKEMDSLKNDFTKYLATADSSLLQTNNLLQQMDKSQKEYESLAAALNGARQELSDRVRELSRSGGKAPLVVEAEKHAQSLQELAKQLEEIKRNTSGDELVRCAVDAATAYENILNAIRAAEDAASKATSASKSAFQTVIKEDLPKRAKTLSSDSEELLNEAKMTQKRLQQVSPALNSLQQTLKTVSVQKDLLDANLTVARDDLHGIQRGDIDSVVIGAKSMVREANGITSEVLDGLNPIQTDLGRIKDSYESARREDFSKALVDANNSVKKLTRKLPDLFIKIESINQQLLPLGNISDNVDRIRELIQQARDAANKVAIPMRFNGKSGVEVRLPNDLEDLKGYTSLSLFLQRPDLRENGGTEDMFVMYLGNKDASKDYIGMAVVDGQLTCVYNLGDREAEVQIDQVLTESESQEAVMDRVKFQRIYQFAKLNYTKEATSTKPKAPGVYDMESASSNTLLNLDPENAVFYVGGYPPGFELPRRLRFPPYKGCIELDDLNENVLSLYNFKTTFNLNTTEVEPCRRRKEESDKNYFEGTGYARIPTQPNAPFPNFMQTIQTTVDRGLLFFAENQDNFISLNIEDGNLMVKYKLNSEPPKEKGIRDTINNGRDHMILISIGKSQKRMLINMNKHSIIIEGEIFDFSTYYLGGIPIAIRERFNISTPAFQGCMKNLKKTSGVVRLNDTVGVTKKCSEDWKLVRTASFSRGGQMSFTNLDVPSLDRFQLSFGFQTFQPSGTLLNHQTRTSSLLVTLEDGHIALSTRDSSSPIFKSPGTYMDGLLHHVSVISDTSGLRLLIDDQVLRRNQRLASFSNAQQSLSMGGGYFEGCISNVFVQRMSQSPEVLDMASKSTKRDAFLGGCSLNKPPFLMLFKSPKGFNKARSFNVNQLLQDAPQAARSIEAWQDGKSCLPPLNTKATHRALQFGDSPTSHLLFKLPQELLKPRLQFSLDIQTTSSRGLVFHTGTRDSFVALYLSEGHVIFALGAGGKKLRLRSKERYHDGKWHSVVFGLSGRKVHLVVDGLRAQEGSLPGNSTISPREQVYLGLSPSRKSKSLPQHSFVGCLRNFQLDSKPLDSPSARSGVSPCLGGSLEKGIYFSQGGGHVVLANSVSLEPALTLTLSIRPRSLTGVLIHIASQSGEHLSVYMEAGKVTTSMNSEAGGTVTSITPKRSLCDGQWHSVTVSIKQHTLHLELDTDNSYTAGQLSFPPNSTRGSLHIGGVPDKLKMLTLPVWNSFFGCLKNIQVNHIPVPITEATDVQGSVSLNGCPDH
Q61789-2
- NameA
- Differences from canonical
- 1-1619: Missing
- 1620-1662: FTETQRLTLGEVGLEEASDTGSGPRAHLVEMCACPPDYTGDSC → MLPAVRWSAWSTGWLWIFGAALGQCLGYGSEQQRVAFLQRPSQNHLQASYMELRPS
Sequence caution
Features
Showing features for alternative sequence, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_003038 | 1-1619 | in isoform A | |||
Sequence: Missing | ||||||
Sequence conflict | 982 | in Ref. 1; CAA58837 | ||||
Sequence: A → R | ||||||
Sequence conflict | 1150 | in Ref. 1; CAA58837 | ||||
Sequence: W → R | ||||||
Sequence conflict | 1224 | in Ref. 1; CAA58837 | ||||
Sequence: E → K | ||||||
Sequence conflict | 1272 | in Ref. 1; CAA58837 | ||||
Sequence: G → GH | ||||||
Sequence conflict | 1291 | in Ref. 1; CAA58837 | ||||
Sequence: R → S | ||||||
Sequence conflict | 1398 | in Ref. 1; CAA58837 | ||||
Sequence: E → K | ||||||
Sequence conflict | 1466 | in Ref. 1; CAA58837 | ||||
Sequence: H → R | ||||||
Sequence conflict | 1479 | in Ref. 1; CAA58837 | ||||
Sequence: R → V | ||||||
Sequence conflict | 1488 | in Ref. 1; CAA58837 | ||||
Sequence: V → F | ||||||
Sequence conflict | 1527-1528 | in Ref. 1; CAA58837 | ||||
Sequence: SS → II | ||||||
Sequence conflict | 1608 | in Ref. 1; CAA58837 | ||||
Sequence: S → P | ||||||
Alternative sequence | VSP_003039 | 1620-1662 | in isoform A | |||
Sequence: FTETQRLTLGEVGLEEASDTGSGPRAHLVEMCACPPDYTGDSC → MLPAVRWSAWSTGWLWIFGAALGQCLGYGSEQQRVAFLQRPSQNHLQASYMELRPS | ||||||
Sequence conflict | 1983-1984 | in Ref. 1; CAA58836/CAA58837 and 6; AAA68091 | ||||
Sequence: KK → QN | ||||||
Sequence conflict | 1987 | in Ref. 1; CAA58836/CAA58837 and 6; AAA68091 | ||||
Sequence: Q → G | ||||||
Sequence conflict | 2463 | in Ref. 1; CAA58836/CAA58837 and 6; AAA68091 | ||||
Sequence: R → G | ||||||
Sequence conflict | 2488 | in Ref. 1; CAA58836/CAA58837 and 6; AAA68091 | ||||
Sequence: F → S | ||||||
Sequence conflict | 2617-2620 | in Ref. 1; CAA58836/CAA58837 | ||||
Sequence: NFMQ → KLSW | ||||||
Sequence conflict | 2724-2725 | in Ref. 1; CAA58836/CAA58837 | ||||
Sequence: NI → PL | ||||||
Sequence conflict | 3257 | in Ref. 1; CAA58836/CAA58837 | ||||
Sequence: D → Y |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X84013 EMBL· GenBank· DDBJ | CAA58836.1 EMBL· GenBank· DDBJ | mRNA | ||
X84014 EMBL· GenBank· DDBJ | CAA58837.1 EMBL· GenBank· DDBJ | mRNA | Frameshift | |
AC102131 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC102248 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC139027 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC157909 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AJ293592 EMBL· GenBank· DDBJ | CAB99254.2 EMBL· GenBank· DDBJ | mRNA | ||
U88353 EMBL· GenBank· DDBJ | AAC53179.1 EMBL· GenBank· DDBJ | mRNA | ||
L20478 EMBL· GenBank· DDBJ | AAA68091.1 EMBL· GenBank· DDBJ | mRNA |