Q61543 · GSLG1_MOUSE

  • Protein
    Golgi apparatus protein 1
  • Gene
    Glg1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Binds fibroblast growth factor and E-selectin (cell-adhesion lectin on endothelial cells mediating the binding of neutrophils).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular matrix
Cellular ComponentGolgi apparatus
Cellular ComponentGolgi medial cisterna
Cellular ComponentGolgi membrane
Cellular Componentmicrotubule organizing center
Cellular Componentplasma membrane
Molecular Functionfibroblast growth factor binding
Biological Processbone morphogenesis
Biological Processnegative regulation of protein processing
Biological Processnegative regulation of transforming growth factor beta receptor signaling pathway
Biological Processprotein processing
Biological Processregulation of chondrocyte differentiation
Biological Processtransforming growth factor beta receptor signaling pathway

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Golgi apparatus protein 1
  • Alternative names
    • E-selectin ligand 1
      (ESL-1
      ; Selel)
    • Golgi sialoglycoprotein MG-160

Gene names

    • Name
      Glg1
    • Synonyms
      Esl1, Mg160, Selel

Organism names

  • Taxonomic identifier
  • Strains
    • FVB/N
    • 129/Sv
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q61543
  • Secondary accessions
    • Q9QZ40

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Single-pass type I membrane protein
Golgi apparatus membrane
; Single-pass type I membrane protein
Golgi outpost
Note: Golgi and microvilli on the cell surface (PubMed:9099943).
Localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, which shapes dendrite morphology by functioning as sites of acentrosomal microtubule nucleation (By similarity).

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain28-1141Extracellular
Transmembrane1142-1162Helical
Topological domain1163-1175Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for signal, chain, glycosylation, modified residue.

TypeIDPosition(s)Description
Signal1-27
ChainPRO_000001112128-1175Golgi apparatus protein 1
Glycosylation161N-linked (GlcNAc...) asparagine
Glycosylation206N-linked (GlcNAc...) asparagine
Glycosylation577N-linked (GlcNAc...) asparagine
Glycosylation673N-linked (GlcNAc...) asparagine
Glycosylation782N-linked (GlcNAc...) asparagine
Modified residue957Phosphoserine

Post-translational modification

Fucosylation is essential for binding to E-selectin.
Contains sialic acid residues.

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Widely expressed; found in myeloid cells, fibroblasts, colon carcinoma, endothelioma, teratocarcinoma, lymphoma, myeloma.

Gene expression databases

Interaction

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for region, compositional bias, repeat.

TypeIDPosition(s)Description
Region30-83Disordered
Compositional bias53-83Polar residues
Region89-108Disordered
Repeat112-145Cys-rich GLG1 1
Repeat146-208Cys-rich GLG1 2
Repeat211-274Cys-rich GLG1 3
Repeat282-342Cys-rich GLG1 4
Repeat343-409Cys-rich GLG1 5
Repeat410-469Cys-rich GLG1 6
Repeat471-533Cys-rich GLG1 7
Repeat534-600Cys-rich GLG1 8
Repeat605-664Cys-rich GLG1 9
Repeat666-724Cys-rich GLG1 10
Repeat725-784Cys-rich GLG1 11
Repeat792-852Cys-rich GLG1 12
Repeat854-907Cys-rich GLG1 13
Repeat908-975Cys-rich GLG1 14
Repeat976-1031Cys-rich GLG1 15
Repeat1037-1097Cys-rich GLG1 16

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    1,175
  • Mass (Da)
    133,734
  • Last updated
    1996-11-01 v1
  • Checksum
    105835DD38C7338B
MAVCGRVRGMFRLSAALPLLLLAAAGAQNGHGQGQGPGTNFGPFPGQGGGGSPAGQQPPQQPQLSQQQQQPPPQQQQQQQQQSLFAAGGLPARRGGAGPGGTGGGWKLAEEESCREDVTRVCPKHTWSNNLAVLECLQDVREPENEISSDCNHLLWNYKLNLTTDPKFESVAREVCKSTISEIKECAEEPVGKGYMVSCLVDHRGNITEYQCHQYITKMTAIIFSDYRLICGFMDDCKNDINLLKCGSIRLGEKDAHSQGEVVSCLEKGLVKEAEEKEPKIQVSELCKKAILRVAELSSDDFHLDRHLYFACRDDRERFCENTQAGEGRVYKCLFNHKFEESMSEKCREALTTRQKLIAQDYKVSYSLAKSCKSDLKKYRCNVENLPRSREARLSYLLMCLESAVHRGRQVSSECQGEMLDYRRMLMEDFSLSPEIILSCRGEIEHHCSGLHRKGRTLHCLMKVVRGEKGNLGMNCQQALQTLIQETDPGADYRIDRALNEACESVIQTACKHIRSGDPMILSCLMEHLYTEKMVEDCEHRLLELQYFISRDWKLDPVLYRKCQGDASRLCHTHGWNETSELMPPGAVFSCLYRHAYRTEEQGRRLSRECRAEVQRILHQRAMDVKLDPALQDKCLIDLGKWCSEKTETGQELECLQDHLDDLAVECRDIVGNLTELESEDIQIEALLMRACEPIIQNFCHDVADNQIDSGDLMECLIQNKHQKDMNEKCAIGVTHFQLVQMKDFRFSYKFKMACKEDVLKLCPNIKKKVDVVICLSTTVRNDTLQEAKEHRVSLKCRKQLRVEELEMTEDIRLEPDLYEACKSDIKNYCSTVQYGNAQIIECLKENKKQLSTRCHQKVFKLQETEMMDPELDYTLMRVCKQMIKRFCPEADSKTMLQCLKQNKNSELMDPKCKQMITKRQITQNTDYRLNPVLRKACKADIPKFCHGILTKAKDDSELEGQVISCLKLRYADQRLSSDCEDQIRIIIQESALDYRLDPQLQLHCSDEIANLCAEEAAAQEQTGQVEECLKVNLLKIKTELCKKEVLNMLKESKADIFVDPVLHTACALDIKHHCAAITPGRGRQMSCLMEALEDKRVRLQPECKKRLNDRIEMWSYAAKVAPADGFSDLAMQVMTSPSKNYILSVISGSICILFLIGLMCGRITKRVTRELKDR

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
E9PWD8E9PWD8_MOUSEGlg1302
F8WHM5F8WHM5_MOUSEGlg11163
F6RSH1F6RSH1_MOUSEGlg1591

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias53-83Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X84037
EMBL· GenBank· DDBJ
CAA58855.1
EMBL· GenBank· DDBJ
mRNA
BC021306
EMBL· GenBank· DDBJ
AAH21306.1
EMBL· GenBank· DDBJ
mRNA
Y12462
EMBL· GenBank· DDBJ
CAA73066.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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