Q61543 · GSLG1_MOUSE
- ProteinGolgi apparatus protein 1
- GeneGlg1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids1175 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Binds fibroblast growth factor and E-selectin (cell-adhesion lectin on endothelial cells mediating the binding of neutrophils).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | extracellular matrix | |
Cellular Component | Golgi apparatus | |
Cellular Component | Golgi medial cisterna | |
Cellular Component | Golgi membrane | |
Cellular Component | microtubule organizing center | |
Cellular Component | plasma membrane | |
Molecular Function | fibroblast growth factor binding | |
Biological Process | bone morphogenesis | |
Biological Process | negative regulation of protein processing | |
Biological Process | negative regulation of transforming growth factor beta receptor signaling pathway | |
Biological Process | protein processing | |
Biological Process | regulation of chondrocyte differentiation | |
Biological Process | transforming growth factor beta receptor signaling pathway |
Keywords
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGolgi apparatus protein 1
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ61543
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Single-pass type I membrane protein
Golgi apparatus membrane ; Single-pass type I membrane protein
Note: Golgi and microvilli on the cell surface (PubMed:9099943).
Localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, which shapes dendrite morphology by functioning as sites of acentrosomal microtubule nucleation (By similarity).
Localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, which shapes dendrite morphology by functioning as sites of acentrosomal microtubule nucleation (By similarity).
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 28-1141 | Extracellular | ||||
Sequence: QNGHGQGQGPGTNFGPFPGQGGGGSPAGQQPPQQPQLSQQQQQPPPQQQQQQQQQSLFAAGGLPARRGGAGPGGTGGGWKLAEEESCREDVTRVCPKHTWSNNLAVLECLQDVREPENEISSDCNHLLWNYKLNLTTDPKFESVAREVCKSTISEIKECAEEPVGKGYMVSCLVDHRGNITEYQCHQYITKMTAIIFSDYRLICGFMDDCKNDINLLKCGSIRLGEKDAHSQGEVVSCLEKGLVKEAEEKEPKIQVSELCKKAILRVAELSSDDFHLDRHLYFACRDDRERFCENTQAGEGRVYKCLFNHKFEESMSEKCREALTTRQKLIAQDYKVSYSLAKSCKSDLKKYRCNVENLPRSREARLSYLLMCLESAVHRGRQVSSECQGEMLDYRRMLMEDFSLSPEIILSCRGEIEHHCSGLHRKGRTLHCLMKVVRGEKGNLGMNCQQALQTLIQETDPGADYRIDRALNEACESVIQTACKHIRSGDPMILSCLMEHLYTEKMVEDCEHRLLELQYFISRDWKLDPVLYRKCQGDASRLCHTHGWNETSELMPPGAVFSCLYRHAYRTEEQGRRLSRECRAEVQRILHQRAMDVKLDPALQDKCLIDLGKWCSEKTETGQELECLQDHLDDLAVECRDIVGNLTELESEDIQIEALLMRACEPIIQNFCHDVADNQIDSGDLMECLIQNKHQKDMNEKCAIGVTHFQLVQMKDFRFSYKFKMACKEDVLKLCPNIKKKVDVVICLSTTVRNDTLQEAKEHRVSLKCRKQLRVEELEMTEDIRLEPDLYEACKSDIKNYCSTVQYGNAQIIECLKENKKQLSTRCHQKVFKLQETEMMDPELDYTLMRVCKQMIKRFCPEADSKTMLQCLKQNKNSELMDPKCKQMITKRQITQNTDYRLNPVLRKACKADIPKFCHGILTKAKDDSELEGQVISCLKLRYADQRLSSDCEDQIRIIIQESALDYRLDPQLQLHCSDEIANLCAEEAAAQEQTGQVEECLKVNLLKIKTELCKKEVLNMLKESKADIFVDPVLHTACALDIKHHCAAITPGRGRQMSCLMEALEDKRVRLQPECKKRLNDRIEMWSYAAKVAPADGFSDLAMQVMTSPSKN | ||||||
Transmembrane | 1142-1162 | Helical | ||||
Sequence: YILSVISGSICILFLIGLMCG | ||||||
Topological domain | 1163-1175 | Cytoplasmic | ||||
Sequence: RITKRVTRELKDR |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, glycosylation, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-27 | |||||
Sequence: MAVCGRVRGMFRLSAALPLLLLAAAGA | ||||||
Chain | PRO_0000011121 | 28-1175 | Golgi apparatus protein 1 | |||
Sequence: QNGHGQGQGPGTNFGPFPGQGGGGSPAGQQPPQQPQLSQQQQQPPPQQQQQQQQQSLFAAGGLPARRGGAGPGGTGGGWKLAEEESCREDVTRVCPKHTWSNNLAVLECLQDVREPENEISSDCNHLLWNYKLNLTTDPKFESVAREVCKSTISEIKECAEEPVGKGYMVSCLVDHRGNITEYQCHQYITKMTAIIFSDYRLICGFMDDCKNDINLLKCGSIRLGEKDAHSQGEVVSCLEKGLVKEAEEKEPKIQVSELCKKAILRVAELSSDDFHLDRHLYFACRDDRERFCENTQAGEGRVYKCLFNHKFEESMSEKCREALTTRQKLIAQDYKVSYSLAKSCKSDLKKYRCNVENLPRSREARLSYLLMCLESAVHRGRQVSSECQGEMLDYRRMLMEDFSLSPEIILSCRGEIEHHCSGLHRKGRTLHCLMKVVRGEKGNLGMNCQQALQTLIQETDPGADYRIDRALNEACESVIQTACKHIRSGDPMILSCLMEHLYTEKMVEDCEHRLLELQYFISRDWKLDPVLYRKCQGDASRLCHTHGWNETSELMPPGAVFSCLYRHAYRTEEQGRRLSRECRAEVQRILHQRAMDVKLDPALQDKCLIDLGKWCSEKTETGQELECLQDHLDDLAVECRDIVGNLTELESEDIQIEALLMRACEPIIQNFCHDVADNQIDSGDLMECLIQNKHQKDMNEKCAIGVTHFQLVQMKDFRFSYKFKMACKEDVLKLCPNIKKKVDVVICLSTTVRNDTLQEAKEHRVSLKCRKQLRVEELEMTEDIRLEPDLYEACKSDIKNYCSTVQYGNAQIIECLKENKKQLSTRCHQKVFKLQETEMMDPELDYTLMRVCKQMIKRFCPEADSKTMLQCLKQNKNSELMDPKCKQMITKRQITQNTDYRLNPVLRKACKADIPKFCHGILTKAKDDSELEGQVISCLKLRYADQRLSSDCEDQIRIIIQESALDYRLDPQLQLHCSDEIANLCAEEAAAQEQTGQVEECLKVNLLKIKTELCKKEVLNMLKESKADIFVDPVLHTACALDIKHHCAAITPGRGRQMSCLMEALEDKRVRLQPECKKRLNDRIEMWSYAAKVAPADGFSDLAMQVMTSPSKNYILSVISGSICILFLIGLMCGRITKRVTRELKDR | ||||||
Glycosylation | 161 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 206 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 577 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 673 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 782 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Modified residue | 957 | Phosphoserine | ||||
Sequence: S |
Post-translational modification
Fucosylation is essential for binding to E-selectin.
Contains sialic acid residues.
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Widely expressed; found in myeloid cells, fibroblasts, colon carcinoma, endothelioma, teratocarcinoma, lymphoma, myeloma.
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, repeat.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 30-83 | Disordered | ||||
Sequence: GHGQGQGPGTNFGPFPGQGGGGSPAGQQPPQQPQLSQQQQQPPPQQQQQQQQQS | ||||||
Compositional bias | 53-83 | Polar residues | ||||
Sequence: PAGQQPPQQPQLSQQQQQPPPQQQQQQQQQS | ||||||
Region | 89-108 | Disordered | ||||
Sequence: GLPARRGGAGPGGTGGGWKL | ||||||
Repeat | 112-145 | Cys-rich GLG1 1 | ||||
Sequence: ESCREDVTRVCPKHTWSNNLAVLECLQDVREPEN | ||||||
Repeat | 146-208 | Cys-rich GLG1 2 | ||||
Sequence: EISSDCNHLLWNYKLNLTTDPKFESVAREVCKSTISEIKECAEEPVGKGYMVSCLVDHRGNIT | ||||||
Repeat | 211-274 | Cys-rich GLG1 3 | ||||
Sequence: QCHQYITKMTAIIFSDYRLICGFMDDCKNDINLLKCGSIRLGEKDAHSQGEVVSCLEKGLVKEA | ||||||
Repeat | 282-342 | Cys-rich GLG1 4 | ||||
Sequence: QVSELCKKAILRVAELSSDDFHLDRHLYFACRDDRERFCENTQAGEGRVYKCLFNHKFEES | ||||||
Repeat | 343-409 | Cys-rich GLG1 5 | ||||
Sequence: MSEKCREALTTRQKLIAQDYKVSYSLAKSCKSDLKKYRCNVENLPRSREARLSYLLMCLESAVHRGR | ||||||
Repeat | 410-469 | Cys-rich GLG1 6 | ||||
Sequence: QVSSECQGEMLDYRRMLMEDFSLSPEIILSCRGEIEHHCSGLHRKGRTLHCLMKVVRGEK | ||||||
Repeat | 471-533 | Cys-rich GLG1 7 | ||||
Sequence: NLGMNCQQALQTLIQETDPGADYRIDRALNEACESVIQTACKHIRSGDPMILSCLMEHLYTEK | ||||||
Repeat | 534-600 | Cys-rich GLG1 8 | ||||
Sequence: MVEDCEHRLLELQYFISRDWKLDPVLYRKCQGDASRLCHTHGWNETSELMPPGAVFSCLYRHAYRTE | ||||||
Repeat | 605-664 | Cys-rich GLG1 9 | ||||
Sequence: RLSRECRAEVQRILHQRAMDVKLDPALQDKCLIDLGKWCSEKTETGQELECLQDHLDDLA | ||||||
Repeat | 666-724 | Cys-rich GLG1 10 | ||||
Sequence: ECRDIVGNLTELESEDIQIEALLMRACEPIIQNFCHDVADNQIDSGDLMECLIQNKHQK | ||||||
Repeat | 725-784 | Cys-rich GLG1 11 | ||||
Sequence: DMNEKCAIGVTHFQLVQMKDFRFSYKFKMACKEDVLKLCPNIKKKVDVVICLSTTVRNDT | ||||||
Repeat | 792-852 | Cys-rich GLG1 12 | ||||
Sequence: RVSLKCRKQLRVEELEMTEDIRLEPDLYEACKSDIKNYCSTVQYGNAQIIECLKENKKQLS | ||||||
Repeat | 854-907 | Cys-rich GLG1 13 | ||||
Sequence: RCHQKVFKLQETEMMDPELDYTLMRVCKQMIKRFCPEADSKTMLQCLKQNKNSE | ||||||
Repeat | 908-975 | Cys-rich GLG1 14 | ||||
Sequence: LMDPKCKQMITKRQITQNTDYRLNPVLRKACKADIPKFCHGILTKAKDDSELEGQVISCLKLRYADQR | ||||||
Repeat | 976-1031 | Cys-rich GLG1 15 | ||||
Sequence: LSSDCEDQIRIIIQESALDYRLDPQLQLHCSDEIANLCAEEAAAQEQTGQVEECLK | ||||||
Repeat | 1037-1097 | Cys-rich GLG1 16 | ||||
Sequence: IKTELCKKEVLNMLKESKADIFVDPVLHTACALDIKHHCAAITPGRGRQMSCLMEALEDKR |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length1,175
- Mass (Da)133,734
- Last updated1996-11-01 v1
- Checksum105835DD38C7338B
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 53-83 | Polar residues | ||||
Sequence: PAGQQPPQQPQLSQQQQQPPPQQQQQQQQQS |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X84037 EMBL· GenBank· DDBJ | CAA58855.1 EMBL· GenBank· DDBJ | mRNA | ||
BC021306 EMBL· GenBank· DDBJ | AAH21306.1 EMBL· GenBank· DDBJ | mRNA | ||
Y12462 EMBL· GenBank· DDBJ | CAA73066.1 EMBL· GenBank· DDBJ | Genomic DNA |