Q61441 · Q61441_MOUSE
- ProteinC-AMP-responsive-element binding protein gamma
- GeneCreb1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids
- Protein existencePredicted
- Annotation score1/5
Publications for Q61441
Phosphorylated CREB binds specifically to the nuclear protein CBP.
- CategoriesFunction, Interaction
- SourceMGI: 88494
Cited inMapped toNuclear protein CBP is a coactivator for the transcription factor CREB.
- CategoriesInteraction
- SourceMGI: 88494
Jacob-induced transcriptional inactivation of CREB promotes Abeta-induced synapse loss in Alzheimer's disease.
- AnnotationJacob-induced transcriptional inactivation of CREB promotes Abeta-induced synapse loss in Alzheimer's disease.
- CategoriesFunction, Interaction
PER2 mediates CREB-dependent light induction of the clock gene Per1.
- AnnotationPER2 mediates CREB-dependent light induction of the clock gene Per1.
- CategoriesFunction, Interaction
Roles of constitutive and signal-dependent protein phosphatase 2A docking motifs in burst attenuation of the cyclic AMP response element-binding protein.
- CategoriesPTM / Processing, Interaction
- SourceMGI: 88494
Tolerance to sustained activation of the cAMP/Creb pathway activity in osteoblastic cells is enabled by loss of p53.
- AnnotationThe cAMP/Creb axis as a potentially actionable therapeutic vulnerability in p53-deficient tumors such as OS.
- CategoriesFunction, Interaction
- SourceGeneRif: 12912
Farnesoid X Receptor (FXR) Interacts with Camp Response Element Binding Protein (CREB) to Modulate Glucagon-Like Peptide-1 (7-36) Amide (GLP-1) Secretion by Intestinal L Cell.
- AnnotationFXR exerts its function in L cells through interacting with CREB a crucial transcriptional regulator of cAMP-CREB signaling pathway to inhibit its transcriptional activity. Targeting FXR to rescue GLP-1 secretion may be a promising strategy for type II diabetes.
- CategoriesFunction, Interaction
- SourceGeneRif: 12912
Nuclear TRAF3 is a negative regulator of CREB in B cells.
- CategoriesInteraction
- SourceMGI: 88494
Palmitoyl acyltransferase Aph2 in cardiac function and the development of cardiomyopathy.
- CategoriesInteraction
- SourceMGI: 88494
FHL3 differentially regulates the expression of MyHC isoforms through interactions with MyoD and pCREB.
- Annotationestablished a model in which FHL3 promotes the expression of MyHC 2a through CREB-mediated transcription and inhibits the expression of MyHC 1/slow by inhibiting MyoD transcription activity during myogenesis
- CategoriesInteraction
- SourceGeneRif: 12912
Genome-wide map of nuclear protein degradation shows NCoR1 turnover as a key to mitochondrial gene regulation.
- CategoriesInteraction
- SourceMGI: 88494
Tmem64 modulates calcium signaling during RANKL-mediated osteoclast differentiation.
- CategoriesInteraction
- SourceMGI: 88494
CREBL2, interacting with CREB, induces adipogenesis in 3T3-L1 adipocytes.
- AnnotationResults of the present study indicate that CREBL2 plays a critical role in adipogenesis and lipogenesis via interaction with CREB.
- CategoriesInteraction
SIK2 is a key regulator for neuronal survival after ischemia via TORC1- CREB.
- AnnotationThese findings suggest that SIK2 plays critical roles in neuronal survival is modulated by CaMK I/IV and regulates CREB via TORC1.
- CategoriesFunction, Interaction
- SourceGeneRif: 12912
Coactivation of the CLOCK-BMAL1 complex by CBP mediates resetting of the circadian clock.
- CategoriesInteraction
- SourceMGI: 88494
Transcriptional activation by MEIS1A in response to protein kinase A signaling requires the transducers of regulated CREB family of CREB co- activators.
- AnnotationMEIS1A transactivation in response to protein kinase A signaling requires the transducers of regulated CREB family of CREB co-activators
- CategoriesInteraction
- SourceGeneRif: 12912
Notch2 integrates signaling by the transcription factors RBP-J and CREB1 to promote T cell cytotoxicity.
- Annotationthe highly regulated dynamic control of T cell cytotoxicity depends on the integration of Notch2 and CREB1 signals.
- CategoriesFunction, Interaction
Deregulated protein kinase A signaling and myospryn expression in muscular dystrophy.
- CategoriesInteraction
- SourceMGI: 88494
Individual CREB-target genes dictate usage of distinct cAMP-responsive coactivation mechanisms.
- Annotationindividual CREB-target gene context dictates the relative contribution of at least two different cAMP-responsive coactivation mechanisms
- CategoriesInteraction
p38 and a p38-interacting protein are critical for downregulation of E- cadherin during mouse gastrulation.
- CategoriesInteraction
- SourceMGI: 88494
Importance of cAMP-response element-binding protein in regulation of expression of the murine cyclic nucleotide phosphodiesterase 3B (Pde3b) gene in differentiating 3T3-L1 preadipocytes.
- AnnotationcAMP-response element-binding protein has a role in regulation of expression of the murine Pde3b gene in differentiating 3T3-L1 preadipocytes
- CategoriesFunction, Interaction