This retrogenic model can be employed to define self-tolerance mechanisms restricting T and B cell responses to GUCY2C to optimize colorectal cancer immunotherapy without autoimmunity.
Relative to controls guanylate cyclase C knockout mice develop severe systemic illness following oral Salmonella infection characterized by disrupted intestinal mucus layer elevated cytokines and organ bacterial load and reduced animal survival.
These findings demonstrate increased radiosensitivity of intestinal epithelial cells in guanylate cyclase C (GCC) knockout mice and establish a role for GCC in preventing apoptosis.
guanylin uroguanylin and E coli enterotoxin act on the mouse kidney in part through a cGMP-dependent GC-C-independent mechanism causing significant natriuresis by renal tubular processes
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.