A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled.Wang Y., Macke J.P., Abella B.S., Andreasson K., Worley P., Gilbert D.J., Copeland N.G., Jenkins N.A., Nathans J.View abstractCited forNUCLEOTIDE SEQUENCE [MRNA]CategoriesSequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Biol. Chem. 271:4468-4476 (1996)Cited in710Mapped to99+
Protein kinase C is differentially stimulated by Wnt and Frizzled homologs in a G-protein-dependent manner.Sheldahl L.C., Park M., Malbon C.C., Moon R.T.View abstractCited forWNT-MEDIATED PKC ACTIVATIONCategoriesFunctionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCCurr. Biol. 9:695-698 (1999)Cited in7Mapped to1
Biochemical characterization of Wnt-frizzled interactions using a soluble, biologically active vertebrate Wnt protein.Hsieh J.C., Rattner A., Smallwood P.M., Nathans J.View abstractCited forSUBCELLULAR LOCATIONCategoriesSubcellular LocationSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCProc. Natl. Acad. Sci. U.S.A. 96:3546-3551 (1999)Cited in7Mapped to33
A tissue-specific atlas of mouse protein phosphorylation and expression.Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.View abstractCited forPHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-656, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]TissueKidneyCategoriesPTM / Processing, SequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCCell 143:1174-1189 (2010)Cited in99+99+Mapped to6
Mutations in Frizzled 6 cause isolated autosomal-recessive nail dysplasia.Frojmark A.S., Schuster J., Sobol M., Entesarian M., Kilander M.B., Gabrikova D., Nawaz S., Baig S.M., Schulte G.[...], Dahl N.View abstractCited forDISRUPTION PHENOTYPECategoriesPhenotypes & VariantsSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCAm. J. Hum. Genet. 88:852-860 (2011)Cited in2Mapped to12
The role of Frizzled3 and Frizzled6 in neural tube closure and in the planar polarity of inner-ear sensory hair cells.Wang Y., Guo N., Nathans J.View abstractCited forFUNCTION, DISRUPTION PHENOTYPE, SUBCELLULAR LOCATION, TISSUE SPECIFICITYCategoriesFunction, Expression, Phenotypes & Variants, Subcellular LocationSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Neurosci. 26:2147-2156 (2006)Cited in3Mapped to21
LMBR1L regulates lymphopoiesis through Wnt/beta-catenin signaling.Choi J.H., Zhong X., McAlpine W., Liao T.C., Zhang D., Fang B., Russell J., Ludwig S., Nair-Gill E.[...], Beutler B.View abstractCited forINTERACTION WITH LMBR1L, SUBCELLULAR LOCATIONCategoriesInteraction, Subcellular LocationSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCScience 364:0-0 (2019)Cited in22Mapped to72
A role for the Wnt gene family in hematopoiesis: expansion of multilineage progenitor cells.Austin T.W., Solar G.P., Ziegler F.C., Liem L., Matthews W.View abstractCategoriesSequences, ExpressionSourceMGI: 108474PubMedEurope PMCBlood 89:3624-3635 (1997)Mapped to28
A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors.Rattner A., Hsieh J.-C., Smallwood P.M., Gilbert D.J., Copeland N.G., Jenkins N.A., Nathans J.View abstractCategoriesSequencesSourceMGI: 108474PubMedEurope PMCProc. Natl. Acad. Sci. U.S.A. 94:2859-2863 (1997)Cited in4Mapped to77
ASH2L Mediates Epidermal Differentiation and Hair Follicle Morphogenesis through H3K4me3 Modification.Wang Q., Zeng S., Liang Y., Zhou R., Wang D.View abstractSourceMGI: 108474PubMedEurope PMCJ Invest Dermatol 0:S0022-202X (24)Mapped to93
Vangl-dependent mesenchymal thinning shapes the distal lung during murine sacculation.Paramore S.V., Trenado-Yuste C., Sharan R., Nelson C.M., Devenport D.View abstractSourceMGI: 108474PubMedEurope PMCDev Cell 59:1302-1316.e5 (2024)Mapped to53
Genetic determinants of micronucleus formation in vivo.Adams D.J., Barlas B., McIntyre R.E., Salguero I., van der Weyden L., Barros A., Vicente J.R., Karimpour N., Haider A.[...], White J.K.View abstractCategoriesFunctionSourceMGI: 108474PubMedEurope PMCNature 627:130-136 (2024)Mapped to99+
Region-specific reversal of epidermal planar polarity in the rosette fancy mouse.Cetera M., Sharan R., Hayward-Lara G., Phillips B., Biswas A., Halley M., Beall E., vonHoldt B., Devenport D.View abstractCategoriesFunctionSourceMGI: 108474PubMedEurope PMCDevelopment 150:dev202078-dev202078 (2023)Mapped to15
Celsr1 and Celsr2 exhibit distinct adhesive interactions and contributions to planar cell polarity.Basta L.P., Sil P., Jones R.A., Little K.A., Hayward-Lara G., Devenport D.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 108474PubMedEurope PMCFront Cell Dev Biol 10:1064907-1064907 (2022)Mapped to47
FZD6 Promotes Melanoma Cell Invasion but Not Proliferation by Regulating Canonical Wnt Signaling and Epithelial‒Mesenchymal Transition.Dong B., Simonson L., Vold S., Oldham E., Barten L., Ahmad N., Chang H.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 108474PubMedEurope PMCJ Invest Dermatol 143:621-629.e6 (2023)Mapped to29
Overactive Wnt5a signaling disrupts hair follicle polarity during mouse skin development.Simonson L., Oldham E., Chang H.View abstractCategoriesFunctionSourceMGI: 108474PubMedEurope PMCDevelopment 149:dev200816-dev200816 (2022)Mapped to99+
Distinct overlapping functions for Prickle1 and Prickle2 in the polarization of the airway epithelium.Kunimoto K., Weiner A.T., Axelrod J.D., Vladar E.K.View abstractCategoriesFunctionSourceMGI: 108474PubMedEurope PMCFront Cell Dev Biol 10:976182-976182 (2022)Mapped to16
Frizzled-6 promotes hematopoietic stem/progenitor cell mobilization and survival during LPS-induced emergency myelopoiesis.Nguyen T.H., Abidin B.M., Heinonen K.M.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 108474PubMedEurope PMCStem Cell Reports 17:2303-2317 (2022)Mapped to6
Identification of a Novel Functional Non-synonymous Single Nucleotide Polymorphism in Frizzled Class Receptor 6 Gene for Involvement in Depressive Symptoms.Han H., Xu M., Wen L., Chen J., Liu Q., Wang J., Li M.D., Yang Z.View abstractCategoriesPhenotypes & VariantsSourceMGI: 108474PubMedEurope PMCFront Mol Neurosci 15:882396-882396 (2022)Mapped to6
Integrated analysis of Wnt signalling system component gene expression.Murphy P., Armit C., Hill B., Venkataraman S., Frankel P., Baldock R.A., Davidson D.R.View abstractCategoriesExpressionSourceMGI: 108474PubMedEurope PMCDevelopment 149:dev200312-dev200312 (2022)Mapped to99+
New mouse models for high resolution and live imaging of planar cell polarity proteins in vivo.Basta L.P., Hill-Oliva M., Paramore S.V., Sharan R., Goh A., Biswas A., Cortez M., Little K.A., Posfai E., Devenport D.View abstractCategoriesSubcellular LocationSourceMGI: 108474PubMedEurope PMCDevelopment 148:dev199695-dev199695 (2021)Mapped to26
Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.Bedogni F., Hevner R.F.View abstractSourceMGI: 108474PubMedEurope PMCFront Mol Neurosci 14:686034-686034 (2021)Mapped to99+
EMX2-GPR156-Galphai reverses hair cell orientation in mechanosensory epithelia.Kindt K.S., Akturk A., Jarysta A., Day M., Beirl A., Flonard M., Tarchini B.View abstractCategoriesFunctionSourceMGI: 108474PubMedEurope PMCNat. Commun. 12:2861-2861 (2021)Cited in2Mapped to99+
Planar cell polarity induces local microtubule bundling for coordinated ciliary beating.Nakayama S., Yano T., Namba T., Konishi S., Takagishi M., Herawati E., Nishida T., Imoto Y., Ishihara S.[...], Tsukita S.View abstractCategoriesFunctionSourceMGI: 108474PubMedEurope PMCJ Cell Biol 220:e202010034-e202010034 (2021)Mapped to47
Celsr1 adhesive interactions mediate the asymmetric organization of planar polarity complexes.Stahley S.N., Basta L.P., Sharan R., Devenport D.View abstractCategoriesFunction, InteractionSourceMGI: 108474PubMedEurope PMCElife 10:e62097-e62097 (2021)Mapped to21