Q60MJ0 · GPA1_CAEBR

  • Protein
    Guanine nucleotide-binding protein alpha-1 subunit
  • Gene
    gpa-1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.

Features

Showing features for binding site.

135750100150200250300350
TypeIDPosition(s)Description
Binding site40-47GTP (UniProtKB | ChEBI)
Binding site47Mg2+ (UniProtKB | ChEBI)
Binding site176-182GTP (UniProtKB | ChEBI)
Binding site182Mg2+ (UniProtKB | ChEBI)
Binding site201-205GTP (UniProtKB | ChEBI)
Binding site270-273GTP (UniProtKB | ChEBI)
Binding site329GTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentheterotrimeric G-protein complex
Molecular FunctionG protein-coupled receptor binding
Molecular FunctionG-protein beta/gamma-subunit complex binding
Molecular FunctionGTP binding
Molecular FunctionGTPase activity
Molecular Functionmetal ion binding
Biological Processadenylate cyclase-modulating G protein-coupled receptor signaling pathway

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Guanine nucleotide-binding protein alpha-1 subunit

Gene names

    • Name
      gpa-1
    • ORF names
      CBG23127

Organism names

  • Taxonomic identifier
  • Strain
    • AF16
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis

Accessions

  • Primary accession
    Q60MJ0
  • Secondary accessions
    • A8Y4M7

Proteomes

Organism-specific databases

Subcellular Location

PTM/Processing

Features

Showing features for initiator methionine, lipidation, chain.

Type
IDPosition(s)Description
Initiator methionine1Removed
Lipidation2N-myristoyl glycine
ChainPRO_00002036282-357Guanine nucleotide-binding protein alpha-1 subunit
Lipidation4S-palmitoyl cysteine

Keywords

Interaction

Subunit

G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, region.

Type
IDPosition(s)Description
Domain32-357G-alpha
Region35-48G1 motif
Region174-182G2 motif
Region197-206G3 motif
Region266-273G4 motif
Region327-332G5 motif

Sequence similarities

Belongs to the G-alpha family. G(q) subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    357
  • Mass (Da)
    40,702
  • Last updated
    2004-11-23 v1
  • MD5 Checksum
    9206E82F3D0B1823C4F1C2E63E87A8B3
MGNCDSRELAEQTKQSKKINTELAIAKKDDENVIKLLLLGAGESGKSTVLKQMRIIHNSGFSQEESMTKRNVVCANTIQAMGALIEGMRQLRIDFVNRICNAHEKLIRETLSENTEYNPFNDAMYTALSDLWADKGIQSAYGKRELFYLADSAKYFFDSLARINEPNYIPTENDILHTRVPTMGVIEVKFQMKGKVFRVFDVGGQRSQRKKWIHCFDDAKALIYVASLSEYDQVLLEDNTTNRMQESLQLFKQVVNNKYFVNTSVILFLNKVDLFEEKIIIKKRSLTIAFDAYTGPQEDVEAAITFIDSKYRAMADNKDKNIYVHKTCATDTHQVQYVLDAVLDTILSSKLKGCGLF

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY634287
EMBL· GenBank· DDBJ
AAW02893.1
EMBL· GenBank· DDBJ
Genomic DNA
HE601533
EMBL· GenBank· DDBJ
CAP39847.3
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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