Q60MJ0 · GPA1_CAEBR
- ProteinGuanine nucleotide-binding protein alpha-1 subunit
- Genegpa-1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids357 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 40-47 | GTP (UniProtKB | ChEBI) | |||
Binding site | 47 | Mg2+ (UniProtKB | ChEBI) | |||
Binding site | 176-182 | GTP (UniProtKB | ChEBI) | |||
Binding site | 182 | Mg2+ (UniProtKB | ChEBI) | |||
Binding site | 201-205 | GTP (UniProtKB | ChEBI) | |||
Binding site | 270-273 | GTP (UniProtKB | ChEBI) | |||
Binding site | 329 | GTP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | heterotrimeric G-protein complex | |
Molecular Function | G protein-coupled receptor binding | |
Molecular Function | G-protein beta/gamma-subunit complex binding | |
Molecular Function | GTP binding | |
Molecular Function | GTPase activity | |
Molecular Function | metal ion binding | |
Biological Process | adenylate cyclase-modulating G protein-coupled receptor signaling pathway |
Keywords
- Molecular function
- Ligand
Names & Taxonomy
Protein names
- Recommended nameGuanine nucleotide-binding protein alpha-1 subunit
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis
Accessions
- Primary accessionQ60MJ0
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for initiator methionine, lipidation, chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Initiator methionine | 1 | Removed | |||
Lipidation | 2 | N-myristoyl glycine | |||
Chain | PRO_0000203628 | 2-357 | Guanine nucleotide-binding protein alpha-1 subunit | ||
Lipidation | 4 | S-palmitoyl cysteine | |||
Keywords
- PTM
Interaction
Subunit
G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 32-357 | G-alpha | |||
Region | 35-48 | G1 motif | |||
Region | 174-182 | G2 motif | |||
Region | 197-206 | G3 motif | |||
Region | 266-273 | G4 motif | |||
Region | 327-332 | G5 motif | |||
Sequence similarities
Belongs to the G-alpha family. G(q) subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length357
- Mass (Da)40,702
- Last updated2004-11-23 v1
- MD5 Checksum9206E82F3D0B1823C4F1C2E63E87A8B3
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY634287 EMBL· GenBank· DDBJ | AAW02893.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HE601533 EMBL· GenBank· DDBJ | CAP39847.3 EMBL· GenBank· DDBJ | Genomic DNA |