Q609V0 · BIOH_METCA

Function

function

The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters.

Pathway

Cofactor biosynthesis; biotin biosynthesis.

Features

Showing features for binding site, active site.

125420406080100120140160180200220240
TypeIDPosition(s)Description
Binding site20substrate
Active site80Nucleophile
Binding site80-81substrate
Binding site141-145substrate
Active site205
Active site233
Binding site233substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functioncarboxylic ester hydrolase activity
Biological Processbiotin biosynthetic process

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Pimeloyl-[acyl-carrier protein] methyl ester esterase
  • EC number
  • Alternative names
    • Biotin synthesis protein BioH
    • Carboxylesterase BioH

Gene names

    • Name
      bioH
    • Ordered locus names
      MCA1127

Organism names

Accessions

  • Primary accession
    Q609V0

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002044811-254Pimeloyl-[acyl-carrier protein] methyl ester esterase

Interaction

Subunit

Monomer.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the AB hydrolase superfamily. Carboxylesterase BioH family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    254
  • Mass (Da)
    27,807
  • Last updated
    2004-11-23 v1
  • Checksum
    D9F08F78ABCC8922
MGLFIETSGRGPEVVLIHGWGMHGGIWSGFVPWLTDRFRVTRIDLPGHGHSPMLADWSLETVAGAVLEAVPRPAHWVGWSLGAMVALEAARMAPGAVASLTLLCGTPRFVAEPGWPGMEAVTLMRFADGFLSDYEDACRRFLALQAWGMPNERELLRGVRSQLSGRPPPERPALLAGLEVLRHADLRGVLRELPQPVQALLGRRDRLVPVELGDALARLKTGLVSHRIDDAPHVPFLTHGERTARLIHEFIASS

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE017282
EMBL· GenBank· DDBJ
AAU92555.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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