Q609V0 · BIOH_METCA
- ProteinPimeloyl-[acyl-carrier protein] methyl ester esterase
- GenebioH
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids254 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters.
Catalytic activity
- 6-carboxyhexanoyl-[ACP] methyl ester + H2O = 6-carboxyhexanoyl-[ACP] + H+ + methanol
Pathway
Cofactor biosynthesis; biotin biosynthesis.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 20 | substrate | ||||
Sequence: W | ||||||
Active site | 80 | Nucleophile | ||||
Sequence: S | ||||||
Binding site | 80-81 | substrate | ||||
Sequence: SL | ||||||
Binding site | 141-145 | substrate | ||||
Sequence: FLALQ | ||||||
Active site | 205 | |||||
Sequence: D | ||||||
Active site | 233 | |||||
Sequence: H | ||||||
Binding site | 233 | substrate | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | carboxylic ester hydrolase activity | |
Biological Process | biotin biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended namePimeloyl-[acyl-carrier protein] methyl ester esterase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Methylococcales > Methylococcaceae > Methylococcus
Accessions
- Primary accessionQ609V0
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000204481 | 1-254 | Pimeloyl-[acyl-carrier protein] methyl ester esterase | |||
Sequence: MGLFIETSGRGPEVVLIHGWGMHGGIWSGFVPWLTDRFRVTRIDLPGHGHSPMLADWSLETVAGAVLEAVPRPAHWVGWSLGAMVALEAARMAPGAVASLTLLCGTPRFVAEPGWPGMEAVTLMRFADGFLSDYEDACRRFLALQAWGMPNERELLRGVRSQLSGRPPPERPALLAGLEVLRHADLRGVLRELPQPVQALLGRRDRLVPVELGDALARLKTGLVSHRIDDAPHVPFLTHGERTARLIHEFIASS |
Interaction
Structure
Sequence
- Sequence statusComplete
- Length254
- Mass (Da)27,807
- Last updated2004-11-23 v1
- ChecksumD9F08F78ABCC8922
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AE017282 EMBL· GenBank· DDBJ | AAU92555.1 EMBL· GenBank· DDBJ | Genomic DNA |