Q60899 · ELAV2_MOUSE

  • Protein
    ELAV-like protein 2
  • Gene
    Elavl2
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

function

RNA-binding protein that binds to the 3' untranslated region (3'UTR) of target mRNAs (PubMed:8668530).
Seems to recognize a GAAA motif (PubMed:8668530).
Can bind to its own 3'UTR, the FOS 3'UTR and the ID 3'UTR (PubMed:8668530).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcerebellar granule cell to Purkinje cell synapse
Cellular Componentribonucleoprotein complex
Cellular Componentsynapse
Molecular FunctionRNA binding
Biological Processcellular response to leukemia inhibitory factor
Biological Processregulation of synapse assembly

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    ELAV-like protein 2
  • Alternative names
    • ELAV-like neuronal protein 1
    • Hu-antigen B (HuB)
    • Nervous system-specific RNA-binding protein Mel-N1

Gene names

    • Name
      Elavl2
    • Synonyms
      Hub

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q60899

Proteomes

Organism-specific databases

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00000815801-360ELAV-like protein 2
Modified residue221Phosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Brain; neural-specific (PubMed:8668530).
Expressed in the hippocampus (PubMed:11573004).

Induction

Up-regulated after memory training in radial arm maze experiments.

Gene expression databases

Interaction

Subunit

Interacts with IGF2BP1 (By similarity).
Interacts with MAP1B light chain LC1 (PubMed:21288476).

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for region, domain.

TypeIDPosition(s)Description
Region1-36Disordered
Domain39-117RRM 1
Domain125-205RRM 2
Domain277-355RRM 3

Sequence similarities

Belongs to the RRM elav family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    360
  • Mass (Da)
    39,577
  • Last updated
    1996-11-01 v1
  • Checksum
    780CDD07F2E97D74
METQLSNGPTCNNTANGPTTVNNNCSSPVDSGNTEDSKTNLIVNYLPQNMTQEELKSLFGSIGEIESCKLVRDKITGQSLGYGFVNYIDPKDAEKAINTLNGLRLQTKTIKVSYARPSSASIRDANLYVSGLPKTMTQKELEQLFSQYGRIITSRILVDQVTGISRGVGFIRFDKRIEAEEAIKGLNGQKPPGATEPITVKFANNPSQKTNQAILSQLYQSPNRRYPGPLAQQAQRFRLDNLLNMAYGVKSRFSPMTIDGMTSLAGINIPGHPGTGWCIFVYNLAPDADESILWQMFGPFGAVTNVKVIRDFNTNKCKGFGFVTMTNYDEAAMAIASLNGYRLGDRVLQVSFKTNKTHKA

Computationally mapped potential isoform sequences

There are 10 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
Q80UJ0Q80UJ0_MOUSEElavl2347
B1AXZ0B1AXZ0_MOUSEElavl2346
B1AXZ3B1AXZ3_MOUSEElavl283
B1AXZ4B1AXZ4_MOUSEElavl2388
B1AXZ5B1AXZ5_MOUSEElavl2389
B1AXZ6B1AXZ6_MOUSEElavl2376
Q80Y51Q80Y51_MOUSEElavl2373
Q3UR02Q3UR02_MOUSEElavl2359
H3BLG7H3BLG7_MOUSEElavl2125
H3BJL9H3BJL9_MOUSEElavl223

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U29088
EMBL· GenBank· DDBJ
AAC52644.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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