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Q60843 · KLF2_MOUSE

  • Protein
    Krueppel-like factor 2
  • Gene
    Klf2
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Transcription factor that binds to the CACCC box in the promoter of target genes such as HBB/beta globin or NOV and activates their transcription. Might be involved in transcriptional regulation by modulating the binding of the RARA nuclear receptor to RARE DNA elements (By similarity).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentchromatin
Cellular Componentnucleus
Molecular FunctionDNA binding
Molecular FunctionDNA-binding transcription factor activity
Molecular FunctionDNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Functionmetal ion binding
Molecular Functionsequence-specific double-stranded DNA binding
Biological Processcell morphogenesis
Biological Processcellular response to cycloheximide
Biological Processcellular response to hydrogen peroxide
Biological Processcellular response to interleukin-1
Biological Processcellular response to laminar fluid shear stress
Biological Processcellular response to peptide
Biological Processcellular response to tumor necrosis factor
Biological Processcellular stress response to acid chemical
Biological Processepigenetic regulation of gene expression
Biological Processerythrocyte homeostasis
Biological Processerythrocyte maturation
Biological Processin utero embryonic development
Biological Processmulticellular organism growth
Biological Processnegative regulation of interleukin-6 production
Biological Processnegative regulation of sprouting angiogenesis
Biological Processnegative regulation of transcription by RNA polymerase II
Biological Processpositive regulation of DNA-templated transcription
Biological Processpositive regulation of nitric oxide biosynthetic process
Biological Processpositive regulation of protein metabolic process
Biological Processpositive regulation of retinoic acid receptor signaling pathway
Biological Processpositive regulation of transcription by RNA polymerase II
Biological Processtype I pneumocyte differentiation
Biological Processvasodilation

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Krueppel-like factor 2
  • Alternative names
    • Lung krueppel-like factor

Gene names

    • Name
      Klf2
    • Synonyms
      Lklf

Organism names

  • Taxonomic identifier
  • Strain
    • C57BL/6 X CBA
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q60843
  • Secondary accessions
    • B2RS60

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Phenotypes & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis121Greatly impairs polyubiquitination. Abolishes polyubiquitination; when associated with R-146.
Mutagenesis146Abolishes polyubiquitination; when associated with R-121.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 3 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain, modified residue.

Type
IDPosition(s)Description
ChainPRO_00000471631-354Krueppel-like factor 2
Modified residue171Phosphothreonine
Modified residue243Phosphothreonine
Modified residue246Phosphoserine

Post-translational modification

Ubiquitinated. Polyubiquitination involves WWP1 and leads to proteasomal degradation of this protein.

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Predominant expression in the lungs and spleen.

Gene expression databases

Interaction

Subunit

Interacts with WWP1.

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for motif, region, compositional bias, zinc finger.

Type
IDPosition(s)Description
Motif42-509aaTAD
Region52-111Disordered
Compositional bias58-84Pro residues
Region110-267Interaction with WWP1
Region145-208Disordered
Compositional bias161-208Pro residues
Zinc finger271-295C2H2-type 1
Zinc finger301-325C2H2-type 2
Zinc finger331-353C2H2-type 3

Domain

The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    354
  • Mass (Da)
    37,657
  • Last updated
    2011-07-27 v2
  • MD5 Checksum
    D9A77799E5F61BECF88F3D9669078588
MALSEPILPSFATFASPCERGLQERWPRNEPEAGGTDEDLNNVLDFILSMGLDGLGAENPPEPPPQPPPPAFYYPEPGAPPPYSIPAASLGTELLRPDLDPPQGPALHGRFLLAPPGRLVKAEPPEVDGGGYGCAPGLAHGPRGLKLEGAPGATGACMRGPAGRPPPPPDTPPLSPDGPLRIPASGPRNPFPPPFGPGPSFGGPGPALHYGPPAPGAFGLFEDAAAAAAALGLAPPATRGLLTPPSSPLELLEAKPKRGRRSWPRKRAATHTCSYTNCGKTYTKSSHLKAHLRTHTGEKPYHCNWEGCGWKFARSDELTRHYRKHTGHRPFQCHLCDRAFSRSDHLALHMKRHM

Features

Showing features for compositional bias, sequence conflict.

Type
IDPosition(s)Description
Compositional bias58-84Pro residues
Sequence conflict88in Ref. 1; AAA86728
Compositional bias161-208Pro residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U25096
EMBL· GenBank· DDBJ
AAA86728.1
EMBL· GenBank· DDBJ
mRNA
BC138737
EMBL· GenBank· DDBJ
AAI38738.1
EMBL· GenBank· DDBJ
mRNA
BC138738
EMBL· GenBank· DDBJ
AAI38739.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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