Q60770 · STXB3_MOUSE
- ProteinSyntaxin-binding protein 3
- GeneStxbp3
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids592 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Together with STX4 and VAMP2, may play a role in insulin-dependent movement of GLUT4 and in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | apical plasma membrane | |
Cellular Component | basolateral plasma membrane | |
Cellular Component | cytosol | |
Cellular Component | phagocytic vesicle | |
Cellular Component | plasma membrane | |
Cellular Component | platelet alpha granule | |
Cellular Component | specific granule | |
Cellular Component | tertiary granule | |
Molecular Function | protein-containing complex binding | |
Molecular Function | syntaxin binding | |
Molecular Function | syntaxin-1 binding | |
Biological Process | brain development | |
Biological Process | cellular response to type II interferon | |
Biological Process | exocytosis | |
Biological Process | insulin secretion | |
Biological Process | intracellular glucose homeostasis | |
Biological Process | negative regulation of calcium ion-dependent exocytosis | |
Biological Process | negative regulation of glucose import | |
Biological Process | neutrophil degranulation | |
Biological Process | platelet aggregation | |
Biological Process | protein to membrane docking | |
Biological Process | response to insulin |
Keywords
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSyntaxin-binding protein 3
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ60770
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: In platelets, predominantly cytosolic. Low amounts membrane-associated (By similarity).
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000206286 | 1-592 | Syntaxin-binding protein 3 | ||
Post-translational modification
Phosphorylated by PKC in platelets in response to thrombin stimulation; phosphorylation inhibits binding to STX4.
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Ubiquitously expressed in all tissues tested.
Gene expression databases
Interaction
Subunit
Interacts with STX4. Interacts with DOC2B; the interaction is direct, occurs at the cell membrane, excludes interaction with STX4 and regulates glucose-stimulated insulin secretion.
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | IntAct | |
---|---|---|---|---|---|
XENO | Q60770 | Stx4 Q08850 | 4 | EBI-8430169, EBI-918243 | |
XENO | Q60770 | Vamp2 P63045 | 2 | EBI-8430169, EBI-520880 | |
BINARY | Q60770-1 | Stx4 P70452 | 3 | EBI-15639434, EBI-645716 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 1-255 | Mediates interaction with DOC2B | |||
Sequence similarities
Belongs to the STXBP/unc-18/SEC1 family.
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
Q60770-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length592
- Mass (Da)67,942
- Last updated1996-11-01 v1
- Checksum7874B71DE107871A
Q60770-2
- Name2
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A2AEC9 | A2AEC9_MOUSE | Stxbp3 | 101 | ||
A0A0G2JEI5 | A0A0G2JEI5_MOUSE | Stxbp3 | 236 | ||
A0A0G2JEQ3 | A0A0G2JEQ3_MOUSE | Stxbp3 | 146 |
Sequence caution
Features
Showing features for sequence conflict, alternative sequence.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Sequence conflict | 123 | in Ref. 3; BAE31079 | |||
Sequence conflict | 166 | in Ref. 3; BAE23717 | |||
Sequence conflict | 303 | in Ref. 3; BAE33068 | |||
Alternative sequence | VSP_037061 | 344-370 | in isoform 2 | ||
Sequence conflict | 361 | in Ref. 3; BAE33068 | |||
Sequence conflict | 467 | in Ref. 3; BAE23717 | |||
Alternative sequence | VSP_037062 | 484-511 | in isoform 2 | ||
Sequence conflict | 489 | in Ref. 3; BAE31079 | |||
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
U19521 EMBL· GenBank· DDBJ | AAA69913.1 EMBL· GenBank· DDBJ | mRNA | ||
D30798 EMBL· GenBank· DDBJ | BAA19478.1 EMBL· GenBank· DDBJ | mRNA | ||
AK138609 EMBL· GenBank· DDBJ | BAE23717.1 EMBL· GenBank· DDBJ | mRNA | ||
AK151466 EMBL· GenBank· DDBJ | BAE30424.1 EMBL· GenBank· DDBJ | mRNA | ||
AK152261 EMBL· GenBank· DDBJ | BAE31079.1 EMBL· GenBank· DDBJ | mRNA | ||
AK155133 EMBL· GenBank· DDBJ | BAE33068.1 EMBL· GenBank· DDBJ | mRNA | ||
AK169799 EMBL· GenBank· DDBJ | BAE41375.1 EMBL· GenBank· DDBJ | mRNA | Frameshift | |
AL671894 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL671917 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC062901 EMBL· GenBank· DDBJ | AAH62901.1 EMBL· GenBank· DDBJ | mRNA |