Q60770 · STXB3_MOUSE

  • Protein
    Syntaxin-binding protein 3
  • Gene
    Stxbp3
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Together with STX4 and VAMP2, may play a role in insulin-dependent movement of GLUT4 and in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentapical plasma membrane
Cellular Componentbasolateral plasma membrane
Cellular Componentcytosol
Cellular Componentphagocytic vesicle
Cellular Componentplasma membrane
Cellular Componentplatelet alpha granule
Cellular Componentspecific granule
Cellular Componenttertiary granule
Molecular Functionprotein-containing complex binding
Molecular Functionsyntaxin binding
Molecular Functionsyntaxin-1 binding
Biological Processbrain development
Biological Processcellular response to type II interferon
Biological Processexocytosis
Biological Processinsulin secretion
Biological Processintracellular glucose homeostasis
Biological Processnegative regulation of calcium ion-dependent exocytosis
Biological Processnegative regulation of glucose import
Biological Processneutrophil degranulation
Biological Processplatelet aggregation
Biological Processprotein to membrane docking
Biological Processresponse to insulin

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Syntaxin-binding protein 3
  • Alternative names
    • MUNC-18-3
    • Mammalian homolog of Unc-18c (Munc-18c)
    • Protein unc-18 homolog 3 (Unc18-3)
    • Protein unc-18 homolog C (Unc-18C)

Gene names

    • Name
      Stxbp3
    • Synonyms
      Stxbp3a, Unc18c

Organism names

  • Taxonomic identifier
  • Strains
    • BALB/cJ
    • C57BL/6J
    • NOD
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q60770
  • Secondary accessions
    • Q3TE73
    • Q3U2S2
    • Q3U8D9
    • Q3UA91
    • Q3UUB0

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002062861-592Syntaxin-binding protein 3

Post-translational modification

Phosphorylated by PKC in platelets in response to thrombin stimulation; phosphorylation inhibits binding to STX4.

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Ubiquitously expressed in all tissues tested.

Gene expression databases

Interaction

Subunit

Interacts with STX4. Interacts with DOC2B; the interaction is direct, occurs at the cell membrane, excludes interaction with STX4 and regulates glucose-stimulated insulin secretion.

Binary interactions

Type
Entry 1
Entry 2Number of experimentsIntAct
XENO Q60770Stx4 Q088504EBI-8430169, EBI-918243
XENO Q60770Vamp2 P630452EBI-8430169, EBI-520880
BINARY Q60770-1Stx4 P704523EBI-15639434, EBI-645716

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region1-255Mediates interaction with DOC2B

Sequence similarities

Belongs to the STXBP/unc-18/SEC1 family.

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

Q60770-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    592
  • Mass (Da)
    67,942
  • Last updated
    1996-11-01 v1
  • Checksum
    7874B71DE107871A
MAPPVSERGLKSVVWRKIKTAVFDDCRKEGEWKIMLLDEFTTKLLSSCCKMTDLLEEGITVIENIYKNREPVRQMKALYFISPTPKSVDCFLRDFGSKSEKKYKAAYIYFTDFCPDSLFNKIKASCSKSIRRCKEINISFIPQESQVYTLDVPDAFYYCYSPDPSNASRKEVVMEAMAEQIVTVCATLDENPGVRYKSKPLDNASKLAQLVEKKLEDYYKIDEKGLIKGKTQSQLLIIDRGFDPVSTVLHELTFQAMAYDLLPIENDTYKYKTDGKEKEAVLEEDDDLWVRVRHRHIAVVLEEIPKLMKEISSTKKATEGKTSLSALTQLMKKMPHFRKQISKQVVHLNLAEDCMNKFKLNIEKLCKTEQDLALGTDAEGQRVKDSMLVLLPVLLNKNHDNCDKIRAVLLYIFGINGTTEENLDRLIHNVKIEDDSDMIRNWSHLGVPIVPPSQQAKPLRKDRSAEETFQLSRWTPFIKDIMEDAIDNRLDSKEWPYCSRCPAVWNGSGAVSARQKPRTNYLELDRKNGSRLIIFVIGGITYSEMRCAYEVSQAHKSCEVIIGSTHILTPRKLLDDIKMLNKSKDKVSFKDE

Q60770-2

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A2AEC9A2AEC9_MOUSEStxbp3101
A0A0G2JEI5A0A0G2JEI5_MOUSEStxbp3236
A0A0G2JEQ3A0A0G2JEQ3_MOUSEStxbp3146

Sequence caution

The sequence BAE41375.1 differs from that shown. Reason: Frameshift

Features

Showing features for sequence conflict, alternative sequence.

Type
IDPosition(s)Description
Sequence conflict123in Ref. 3; BAE31079
Sequence conflict166in Ref. 3; BAE23717
Sequence conflict303in Ref. 3; BAE33068
Alternative sequenceVSP_037061344-370in isoform 2
Sequence conflict361in Ref. 3; BAE33068
Sequence conflict467in Ref. 3; BAE23717
Alternative sequenceVSP_037062484-511in isoform 2
Sequence conflict489in Ref. 3; BAE31079

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U19521
EMBL· GenBank· DDBJ
AAA69913.1
EMBL· GenBank· DDBJ
mRNA
D30798
EMBL· GenBank· DDBJ
BAA19478.1
EMBL· GenBank· DDBJ
mRNA
AK138609
EMBL· GenBank· DDBJ
BAE23717.1
EMBL· GenBank· DDBJ
mRNA
AK151466
EMBL· GenBank· DDBJ
BAE30424.1
EMBL· GenBank· DDBJ
mRNA
AK152261
EMBL· GenBank· DDBJ
BAE31079.1
EMBL· GenBank· DDBJ
mRNA
AK155133
EMBL· GenBank· DDBJ
BAE33068.1
EMBL· GenBank· DDBJ
mRNA
AK169799
EMBL· GenBank· DDBJ
BAE41375.1
EMBL· GenBank· DDBJ
mRNA Frameshift
AL671894
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AL671917
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC062901
EMBL· GenBank· DDBJ
AAH62901.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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