Q60665 · SKIL_MOUSE

  • Protein
    Ski-like protein
  • Gene
    Skil
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

May have regulatory role in cell division or differentiation in response to extracellular signals.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentacrosomal vesicle
Cellular Componentnucleus
Cellular Componentprotein-containing complex
Molecular Functionchromatin binding
Molecular FunctionDNA-binding transcription repressor activity, RNA polymerase II-specific
Molecular FunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular FunctionSMAD binding
Biological Processblastocyst formation
Biological Processcell differentiation
Biological Processextrinsic apoptotic signaling pathway via death domain receptors
Biological Processintrinsic apoptotic signaling pathway in response to DNA damage
Biological Processlens fiber cell differentiation
Biological Processlymphocyte homeostasis
Biological Processnegative regulation of cell differentiation
Biological Processnegative regulation of transcription by RNA polymerase II
Biological Processnegative regulation of transforming growth factor beta receptor signaling pathway
Biological Processpositive regulation of axonogenesis
Biological Processpositive regulation of extrinsic apoptotic signaling pathway via death domain receptors
Biological Processpositive regulation of intrinsic apoptotic signaling pathway in response to DNA damage
Biological Processregulation of cell cycle
Biological Processresponse to cytokine
Biological Processspermatogenesis
Biological Processtransforming growth factor beta receptor signaling pathway

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Ski-like protein
  • Alternative names
    • Ski-related oncogene
    • Ski-related protein

Gene names

    • Name
      Skil
    • Synonyms
      Skir, Sno

Organism names

  • Taxonomic identifier
  • Strains
    • BALB/cJ
    • C3H/HeJ
    • FVB/N
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q60665
  • Secondary accessions
    • Q60702
    • Q78E90
    • Q80VK5

Proteomes

Organism-specific databases

PTM/Processing

Features

Showing features for chain, cross-link, modified residue.

Type
IDPosition(s)Description
ChainPRO_00001293881-675Ski-like protein
Cross-link47Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)
Cross-link67Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)
Modified residue449Phosphoserine
Cross-link486Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)
Cross-link518Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)

Post-translational modification

Ubiquitinated by RNF111 and ARK2C, promoting proteasomal degradation, leading to enhance the BMP-Smad signaling.

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Interacts with CPNE4 (via VWFA domain) (PubMed:12522145).
Interacts with SMAD2, SMAD3 and RNF111. Interacts with WWP1 (By similarity).

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for compositional bias, region, coiled coil.

Type
IDPosition(s)Description
Compositional bias1-16Polar residues
Region1-28Disordered
Region415-461Disordered
Compositional bias426-443Basic and acidic residues
Compositional bias475-496Polar residues
Region475-518Disordered
Compositional bias498-518Basic and acidic residues
Coiled coil526-669

Sequence similarities

Belongs to the SKI family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

Q60665-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    675
  • Mass (Da)
    76,359
  • Last updated
    2005-06-21 v2
  • Checksum
    CE17BBC167693869
MENLQSKFSLVQGSNKKLNGMEDDGSPPVKKMMTDIHANGKTLTKVKKEHLDDYGDASVEPDGEHAKRNRVSLPETLNLNPSLKHTLAQFHLSSQSSLGGPAAFSARYSQESMSPTVFLPLPSPQVLPGPLLIPSDSSTELTQTLLEGESISCFQVGGEKRLCLPQVLNSVLREFSLQQINTVCDELYIYCSRCTSDQLHILKVLGILPFNAPSCGLITLTDAQRLCNALLRPRTFPQNGSILPAKSSLAQLKETGSAFEVEHECLGKCQGLFAPQFYVQPDAPCIQCLECCGMFAPQTFVMHSHRSPDKRTCHWGFESAKWHCYLHVNQKYLGTPEEKKLKIILEEMKEKFSMRNGKRIQSKTDTPSGMELPSWYPVIKQEGDHVPQTHSFLHPSYYLYMCDKVVAPNVSLTSAASQSKEATKAETSKSTSKQSEKPHESSQHQKTVSYPDVSLEEQEKMDLKTSRELYSCLDSSISNNSTSRKKSESAVCSLVRGTSKRDSEDSSPLLVRDGEDDKGKIMEDVMRTYVRQQEKLNSILQRKQQLQMEVEMLSSSKAMKELTEEQQNLQKELESLQSEHAQRMEEFYIEQRDLEKKLEQVMQQKCTCDSTLEKDREAEYAAQLAELRQRLDHAEADRQELQDELRQEREARQKLEMMIKELKLQIGKSSKPSKD

Q60665-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 428-474: SKSTSKQSEKPHESSQHQKTVSYPDVSLEEQEKMDLKTSRELYSCLD → N

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
D3YYG2D3YYG2_MOUSESkil187
D3Z7C5D3Z7C5_MOUSESkil549

Features

Showing features for compositional bias, sequence conflict, alternative sequence.

Type
IDPosition(s)Description
Compositional bias1-16Polar residues
Sequence conflict63-66in Ref. 2; AAB65849
Sequence conflict130in Ref. 2; AAB65849
Sequence conflict150in Ref. 2; AAB65849
Sequence conflict205in Ref. 2; AAB65849
Sequence conflict229in Ref. 2; AAB65849
Sequence conflict302-303in Ref. 1; AAB50266/AAB50267
Compositional bias426-443Basic and acidic residues
Alternative sequenceVSP_014265428-474in isoform 2
Compositional bias475-496Polar residues
Compositional bias498-518Basic and acidic residues
Sequence conflict542in Ref. 1; AAB50266/AAB50267
Sequence conflict618in Ref. 1; AAB50266/AAB50267
Sequence conflict622in Ref. 2; AAB65849
Sequence conflict638-639in Ref. 2; AAB65849

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U10530
EMBL· GenBank· DDBJ
AAB50266.1
EMBL· GenBank· DDBJ
mRNA
U10532
EMBL· GenBank· DDBJ
AAB50267.1
EMBL· GenBank· DDBJ
mRNA
U14655
EMBL· GenBank· DDBJ
AAB65849.1
EMBL· GenBank· DDBJ
mRNA
BC049934
EMBL· GenBank· DDBJ
AAH49934.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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