Q60612 · AA1R_MOUSE

  • Protein
    Adenosine receptor A1
  • Gene
    Adora1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    5/5

Function

function

Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentasymmetric synapse
Cellular Componentaxolemma
Cellular Componentbasolateral plasma membrane
Cellular Componentcalyx of Held
Cellular Componentcell body
Cellular Componentdendrite
Cellular Componentdendritic spine
Cellular Componentneuronal cell body
Cellular Componentplasma membrane
Cellular Componentpostsynaptic membrane
Cellular Componentpresynaptic active zone
Cellular Componentpresynaptic membrane
Cellular Componentsynapse
Cellular Componentterminal bouton
Molecular FunctionG protein-coupled adenosine receptor activity
Molecular FunctionG protein-coupled receptor binding
Molecular FunctionG-protein beta/gamma-subunit complex binding
Molecular Functionheat shock protein binding
Molecular Functionheterotrimeric G-protein binding
Molecular Functionprotein heterodimerization activity
Molecular Functionprotein-containing complex binding
Molecular Functionpurine nucleoside binding
Biological Processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
Biological Processcognition
Biological Processdetection of temperature stimulus involved in sensory perception of pain
Biological Processexcitatory postsynaptic potential
Biological Processfatty acid homeostasis
Biological ProcessG protein-coupled receptor signaling pathway
Biological Processinhibition of non-skeletal tissue mineralization
Biological Processleukocyte migration
Biological Processlipid catabolic process
Biological Processlong-term synaptic depression
Biological Processmucus secretion
Biological Processnegative regulation of acute inflammatory response
Biological Processnegative regulation of apoptotic process
Biological Processnegative regulation of blood pressure
Biological Processnegative regulation of cell population proliferation
Biological Processnegative regulation of circadian sleep/wake cycle, non-REM sleep
Biological Processnegative regulation of circadian sleep/wake cycle, sleep
Biological Processnegative regulation of glutamate secretion
Biological Processnegative regulation of hormone secretion
Biological Processnegative regulation of inflammatory response
Biological Processnegative regulation of leukocyte migration
Biological Processnegative regulation of lipid catabolic process
Biological Processnegative regulation of long-term synaptic depression
Biological Processnegative regulation of long-term synaptic potentiation
Biological Processnegative regulation of mucus secretion
Biological Processnegative regulation of neurotrophin production
Biological Processnegative regulation of synaptic transmission, GABAergic
Biological Processnegative regulation of synaptic transmission, glutamatergic
Biological Processnegative regulation of systemic arterial blood pressure
Biological Processpositive regulation of blood pressure
Biological Processpositive regulation of lipid catabolic process
Biological Processpositive regulation of MAPK cascade
Biological Processpositive regulation of nucleoside transport
Biological Processpositive regulation of peptide secretion
Biological Processpositive regulation of potassium ion transport
Biological Processpositive regulation of protein dephosphorylation
Biological Processpositive regulation of systemic arterial blood pressure
Biological Processprotein targeting to membrane
Biological Processregulation of cardiac muscle cell contraction
Biological Processregulation of cardiac muscle contraction
Biological Processregulation of glomerular filtration
Biological Processregulation of presynaptic cytosolic calcium ion concentration
Biological Processregulation of respiratory gaseous exchange by nervous system process
Biological Processregulation of sensory perception of pain
Biological Processresponse to hypoxia
Biological Processresponse to purine-containing compound
Biological Processtemperature homeostasis
Biological Processtriglyceride homeostasis
Biological Processvasodilation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Adenosine receptor A1

Gene names

    • Name
      Adora1

Organism names

  • Taxonomic identifier
  • Strains
    • BALB/cJ
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q60612
  • Secondary accessions
    • Q8BGU7
    • Q9WUF9

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-10Extracellular
Transmembrane11-33Helical; Name=1
Topological domain34-46Cytoplasmic
Transmembrane47-69Helical; Name=2
Topological domain70-80Extracellular
Transmembrane81-102Helical; Name=3
Topological domain103-123Cytoplasmic
Transmembrane124-146Helical; Name=4
Topological domain147-176Extracellular
Transmembrane177-201Helical; Name=5
Topological domain202-235Cytoplasmic
Transmembrane236-259Helical; Name=6
Topological domain260-267Extracellular
Transmembrane268-292Helical; Name=7
Topological domain293-326Cytoplasmic

Keywords

Phenotypes & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 22 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Chemistry

PTM/Processing

Features

Showing features for chain, disulfide bond, glycosylation, lipidation.

TypeIDPosition(s)Description
ChainPRO_00000689921-326Adenosine receptor A1
Disulfide bond80↔169
Glycosylation148N-linked (GlcNAc...) asparagine
Glycosylation159N-linked (GlcNAc...) asparagine
Lipidation309S-palmitoyl cysteine

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Chemistry

Miscellaneous

Structure

Family & Domains

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Keywords

Phylogenomic databases

Family and domain databases

Protein family/group databases

Sequence

  • Sequence status
    Complete
  • Length
    326
  • Mass (Da)
    36,638
  • Last updated
    2011-07-27 v4
  • Checksum
    6E5AC2D94447963C
MPPYISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNNLSEVEQAWIANGSVGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPTCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTFLKIWNDHFRCQPKPPIEEDIPEEKADD

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A087WRW7A0A087WRW7_MOUSEAdora1178

Sequence caution

The sequence AAA18999.1 differs from that shown. Reason: Erroneous initiation

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict10in Ref. 1
Sequence conflict107in Ref. 4; AAD31843
Sequence conflict325in Ref. 1; AAA18999

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U05671
EMBL· GenBank· DDBJ
AAA18999.1
EMBL· GenBank· DDBJ
mRNA Different initiation
AK043954
EMBL· GenBank· DDBJ
BAC31713.1
EMBL· GenBank· DDBJ
mRNA
AK045729
EMBL· GenBank· DDBJ
BAC32474.1
EMBL· GenBank· DDBJ
mRNA
AK134553
EMBL· GenBank· DDBJ
BAE22183.1
EMBL· GenBank· DDBJ
mRNA
CH466520
EMBL· GenBank· DDBJ
EDL39623.1
EMBL· GenBank· DDBJ
Genomic DNA
AF133099
EMBL· GenBank· DDBJ
AAD31843.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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