Q60612 · AA1R_MOUSE
- ProteinAdenosine receptor A1
- GeneAdora1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids326 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score5/5
Function
function
Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAdenosine receptor A1
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ60612
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-10 | Extracellular | ||||
Sequence: MPPYISAFQA | ||||||
Transmembrane | 11-33 | Helical; Name=1 | ||||
Sequence: AYIGIEVLIALVSVPGNVLVIWA | ||||||
Topological domain | 34-46 | Cytoplasmic | ||||
Sequence: VKVNQALRDATFC | ||||||
Transmembrane | 47-69 | Helical; Name=2 | ||||
Sequence: FIVSLAVADVAVGALVIPLAILI | ||||||
Topological domain | 70-80 | Extracellular | ||||
Sequence: NIGPQTYFHTC | ||||||
Transmembrane | 81-102 | Helical; Name=3 | ||||
Sequence: LMVACPVLILTQSSILALLAIA | ||||||
Topological domain | 103-123 | Cytoplasmic | ||||
Sequence: VDRYLRVKIPLRYKTVVTQRR | ||||||
Transmembrane | 124-146 | Helical; Name=4 | ||||
Sequence: AAVAIAGCWILSLVVGLTPMFGW | ||||||
Topological domain | 147-176 | Extracellular | ||||
Sequence: NNLSEVEQAWIANGSVGEPVIKCEFEKVIS | ||||||
Transmembrane | 177-201 | Helical; Name=5 | ||||
Sequence: MEYMVYFNFFVWVLPPLLLMVLIYL | ||||||
Topological domain | 202-235 | Cytoplasmic | ||||
Sequence: EVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKS | ||||||
Transmembrane | 236-259 | Helical; Name=6 | ||||
Sequence: LALILFLFALSWLPLHILNCITLF | ||||||
Topological domain | 260-267 | Extracellular | ||||
Sequence: CPTCQKPS | ||||||
Transmembrane | 268-292 | Helical; Name=7 | ||||
Sequence: ILIYIAIFLTHGNSAMNPIVYAFRI | ||||||
Topological domain | 293-326 | Cytoplasmic | ||||
Sequence: HKFRVTFLKIWNDHFRCQPKPPIEEDIPEEKADD |
Keywords
- Cellular component
Phenotypes & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 22 variants from UniProt as well as other sources including ClinVar and dbSNP.
Chemistry
PTM/Processing
Features
Showing features for chain, disulfide bond, glycosylation, lipidation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000068992 | 1-326 | Adenosine receptor A1 | |||
Sequence: MPPYISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNNLSEVEQAWIANGSVGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPTCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTFLKIWNDHFRCQPKPPIEEDIPEEKADD | ||||||
Disulfide bond | 80↔169 | |||||
Sequence: CLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNNLSEVEQAWIANGSVGEPVIKC | ||||||
Glycosylation | 148 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 159 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Lipidation | 309 | S-palmitoyl cysteine | ||||
Sequence: C |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Gene expression databases
Structure
Family & Domains
Sequence
- Sequence statusComplete
- Length326
- Mass (Da)36,638
- Last updated2011-07-27 v4
- Checksum6E5AC2D94447963C
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A087WRW7 | A0A087WRW7_MOUSE | Adora1 | 178 |
Sequence caution
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 10 | in Ref. 1 | ||||
Sequence: A → G | ||||||
Sequence conflict | 107 | in Ref. 4; AAD31843 | ||||
Sequence: L → P | ||||||
Sequence conflict | 325 | in Ref. 1; AAA18999 | ||||
Sequence: D → E |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
U05671 EMBL· GenBank· DDBJ | AAA18999.1 EMBL· GenBank· DDBJ | mRNA | Different initiation | |
AK043954 EMBL· GenBank· DDBJ | BAC31713.1 EMBL· GenBank· DDBJ | mRNA | ||
AK045729 EMBL· GenBank· DDBJ | BAC32474.1 EMBL· GenBank· DDBJ | mRNA | ||
AK134553 EMBL· GenBank· DDBJ | BAE22183.1 EMBL· GenBank· DDBJ | mRNA | ||
CH466520 EMBL· GenBank· DDBJ | EDL39623.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF133099 EMBL· GenBank· DDBJ | AAD31843.1 EMBL· GenBank· DDBJ | Genomic DNA |