Q60604 · SCIN_MOUSE

  • Protein
    Scinderin
  • Gene
    Scin
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Ca2+-dependent actin filament-severing protein that has a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane (PubMed:9671468).
Severing activity is inhibited by phosphatidylinositol 4,5-bis-phosphate (PIP2) (By similarity).
In vitro, also has barbed end capping and nucleating activities in the presence of Ca2+ (PubMed:9671468).
Required for megakaryocyte differentiation, maturation, polyploidization and apoptosis with the release of platelet-like particles (By similarity).
Plays a role in osteoclastogenesis (OCG) and actin cytoskeletal organization in osteoclasts (PubMed:25275604, PubMed:25681458).
Regulates chondrocyte proliferation and differentiation (By similarity).
Inhibits cell proliferation and tumorigenesis. Signaling is mediated by MAPK, p38 and JNK pathways (By similarity).

Isoform 2

Fails to nucleate actin polymerization, although it severs and caps actin filaments in a Ca2+-dependent manner.

Features

Showing features for binding site.

1715100200300400500600700
TypeIDPosition(s)Description
Binding site112-119a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) (UniProtKB | ChEBI)
Binding site138-146a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) (UniProtKB | ChEBI)
Binding site538Ca2+ 1 (UniProtKB | ChEBI)
Binding site539Ca2+ 1 (UniProtKB | ChEBI)
Binding site562Ca2+ 1 (UniProtKB | ChEBI)
Binding site643Ca2+ 2 (UniProtKB | ChEBI)
Binding site644Ca2+ 2 (UniProtKB | ChEBI)
Binding site666Ca2+ 2 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentactin cytoskeleton
Cellular Componentanchoring junction
Cellular Componentbrush border
Cellular Componentcell projection
Cellular Componentcytoplasm
Cellular Componentpodosome
Cellular Componentprotein-containing complex
Molecular Functionactin filament binding
Molecular Functionmetal ion binding
Molecular Functionphosphatidylinositol-4,5-bisphosphate binding
Biological Processactin filament severing
Biological Processactin polymerization or depolymerization
Biological Processbarbed-end actin filament capping
Biological Processcell projection assembly
Biological Processcentral nervous system development
Biological Processnegative regulation of cell population proliferation
Biological Processpositive regulation of actin nucleation
Biological Processpositive regulation of apoptotic process
Biological Processpositive regulation of megakaryocyte differentiation
Biological Processregulation of chondrocyte differentiation
Biological Processsequestering of actin monomers

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Scinderin
  • Alternative names
    • Adseverin
    • Gelsolin-like protein

Gene names

    • Name
      Scin

Organism names

  • Taxonomic identifier
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q60604
  • Secondary accessions
    • O08988
    • O08990
    • Q6P4N8

Proteomes

Organism-specific databases

Phenotypes & Variants

Disruption phenotype

Knockdown in bone marrow monocytes protect mice from bone resorption in periodontal disease model.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 26 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00002187451-715Scinderin
Modified residue102Phosphotyrosine
Modified residue599Phosphotyrosine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Ubiquitous. Highly expressed in mature osteoclasts (at protein level) (PubMed:25275604).
Isoform 2 is expressed in blood cells (PubMed:9671468).

Developmental stage

Expression is induced during osteoclastogenesis.

Gene expression databases

Interaction

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for region, repeat.

TypeIDPosition(s)Description
Region1-363Actin-severing
Repeat27-76Gelsolin-like 1
Repeat148-188Gelsolin-like 2
Repeat265-307Gelsolin-like 3
Region364-715Ca2+-dependent actin binding
Repeat398-451Gelsolin-like 4
Repeat523-564Gelsolin-like 5
Repeat626-668Gelsolin-like 6

Sequence similarities

Belongs to the villin/gelsolin family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

Q60604-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    715
  • Mass (Da)
    80,254
  • Last updated
    2011-07-27 v3
  • Checksum
    6EF9F45FBC82E249
MAQELQHPEFARAGQQAGLQVWRVEKLELVPVPQGAYGDFYVGDAYLVLHTTKSSRGFSYRLHFWLGKECSQDESTAAAIFTVQMDDYLGGKPVQSRELQGYESTDFVGYFKGGLKYKAGGVASGLNHVLTNDLTAKRLLHVKGRRVVRATEVPLSWESFNKGDCFIIDLGTEIYQWCGSSCNKYERLKASQVAIGIRDNERKGRSQLIVVEEGSEPSELMKVLGRKPELPDGDNDDDVVADISNRKMAKLYMVSDASGSMKVTLVAEENPFSMGMLLSEECFILDHGAAKQIFVWKGKNANPQERKTAMKTAEEFLQKMKYSTNTQIQVLPEGGETPIFKQFFKDWKDKDQSDGFGKVYITEKVAQIKQIPFDASKLHSSPQMAAQHNMVDDGSGGVEIWRVENSGRVQIDPSSYGEFYGGDCYIILYTYPRGQIIYTWQGANATRDELTMSAFLTVQLDRSLGGQAVQVRVSQGKEPAHLLSLFKDKPLIIYKNGTSKKEGQAPAPPTRLFQVRRNLASITRIVEVDVDANSLNSNDTFVLKLPRNNGFIWIGKGASQEEEKGAEYVADVLKCKASRIQEGKEPEEFWNSLGGRGDYQTSPLLETRAEDHPPRLYGCSNKTGRFIIEEVPGEFTQDDLAEDDVMLLDAWEQIFIWIGKDANEVEKKESVKSAKMYLETDPSGRDKRTPIVIIKQGHEPPTFTGWFLGWDSSRW

Q60604-2

  • Name
    2
  • Synonyms
    D5
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Features

Showing features for sequence conflict, alternative sequence.

TypeIDPosition(s)Description
Sequence conflict44-45in Ref. 1; AAB61682/CAA74304
Alternative sequenceVSP_006730528-627in isoform 2

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U04354
EMBL· GenBank· DDBJ
AAB61682.1
EMBL· GenBank· DDBJ
mRNA
Y13971
EMBL· GenBank· DDBJ
CAA74304.1
EMBL· GenBank· DDBJ
mRNA
AK133484
EMBL· GenBank· DDBJ
BAE21681.1
EMBL· GenBank· DDBJ
mRNA
BC063328
EMBL· GenBank· DDBJ
AAH63328.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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