Q60484 · 5HT1D_CAVPO

Function

function

G-protein coupled receptor for 5-hydroxytryptamine (serotonin) (By similarity).
Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. HTR1D is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission by inhibiting adenylate cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity. May also play a role in regulating the release of other neurotransmitters. May play a role in vasoconstriction (By similarity).

Features

Showing features for binding site.

137650100150200250300350
TypeIDPosition(s)Description
Binding site118serotonin (UniProtKB | ChEBI)
Binding site122serotonin (UniProtKB | ChEBI)
Binding site320serotonin (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentplasma membrane
Cellular Componentsynapse
Molecular Functiondopamine neurotransmitter receptor activity, coupled via Gs
Molecular FunctionG protein-coupled serotonin receptor activity
Biological Processadenylate cyclase-activating adrenergic receptor signaling pathway
Biological Processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
Biological Processregulation of behavior
Biological Processregulation of locomotion
Biological Processsmooth muscle contraction
Biological Processvasoconstriction

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    5-hydroxytryptamine receptor 1D
  • Short names
    5-HT-1D; 5-HT1D
  • Alternative names
    • Serotonin receptor 1D

Gene names

    • Name
      HTR1D

Organism names

  • Taxonomic identifier
  • Strain
    • Hartley
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Hystricomorpha > Caviidae > Cavia

Accessions

  • Primary accession
    Q60484
  • Secondary accessions
    • O08891

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane39-64Helical; Name=1
Transmembrane76-97Helical; Name=2
Transmembrane110-134Helical; Name=3
Transmembrane155-176Helical; Name=4
Transmembrane195-218Helical; Name=5
Transmembrane300-325Helical; Name=6
Transmembrane335-358Helical; Name=7

Keywords

Phenotypes & Variants

PTM/Processing

Features

Showing features for chain, glycosylation, disulfide bond.

Type
IDPosition(s)Description
ChainPRO_00000689261-3765-hydroxytryptamine receptor 1D
Glycosylation5N-linked (GlcNAc...) asparagine
Glycosylation17N-linked (GlcNAc...) asparagine
Glycosylation21N-linked (GlcNAc...) asparagine
Disulfide bond111↔188

Keywords

PTM databases

Interaction

Subunit

Homodimer. Heterodimer with HTR1B.

Protein-protein interaction databases

Chemistry

Structure

Family & Domains

Features

Showing features for region, motif.

Type
IDPosition(s)Description
Region1-22Disordered
Motif135-137DRY motif; important for ligand-induced conformation changes
Motif351-355NPxxY motif; important for ligand-induced conformation changes and signaling

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Keywords

Phylogenomic databases

Family and domain databases

Protein family/group databases

Sequence

  • Sequence status
    Complete
  • Length
    376
  • Mass (Da)
    41,769
  • Last updated
    1997-11-01 v1
  • MD5 Checksum
    F49EAA39F2B89C8E1D0EFE720C744686
MSPPNQSEEGLPQEASNRSLNATETPGDWDPGLLQALKVSLVVVLSIITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAGAMIAAVWVISICISIPPLFWRQAQAQEEMSDCLVNTSQISYTIYSTCGAFYIPSVLLIILYSRIYRAARSRILNPPSLSGKRFTTAHLITGSAGSSLCSLNPSLHEGHMHPGSPLFFNHVRIKLADSVLERKRISAARERKATKTLGIILGAFIVCWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPIIYTVFNEDFRQAFQKVVHFRKAS

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict222in Ref. 2; AAB58499

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X94436
EMBL· GenBank· DDBJ
CAA64210.1
EMBL· GenBank· DDBJ
Genomic DNA
U82174
EMBL· GenBank· DDBJ
AAB58499.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help