Q601Z4 · Q601Z4_MESH2

Function

function

Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation.

Catalytic activity

  • Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).
    EC:3.1.21.10 (UniProtKB | ENZYME | Rhea)

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Features

Showing features for binding site, site.

116420406080100120140160
Type
IDPosition(s)Description
Binding site60Mg2+ (UniProtKB | ChEBI)
Binding site62Mg2+ (UniProtKB | ChEBI)
Binding site75Mg2+ (UniProtKB | ChEBI)
Site77Transition state stabilizer
Binding site93Mg2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionendonuclease activity
Molecular Functionmagnesium ion binding
Molecular Functionnucleic acid binding
Biological Processchromosome segregation
Biological ProcessDNA recombination
Biological ProcessDNA repair

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Holliday junction resolvase RecU
  • EC number
  • Alternative names
    • Recombination protein U homolog

Gene names

    • Name
      recU
    • Ordered locus names
      mhp057

Organism names

Accessions

  • Primary accession
    Q601Z4

Proteomes

Subcellular Location

Keywords

Family & Domains

Sequence similarities

Belongs to the RecU family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    164
  • Mass (Da)
    19,222
  • Last updated
    2004-11-23 v1
  • Checksum
    39572DEBCBD3FF74
MLYMNHKNRGMFLEKIINNTIEFYCENGIGIFHKKNLDISFKAVSKDLAVNDAFIFKKSTVDYYGIYKGIFVAFEAKSTNENVLNLKQIPEHQLSYLQKIREHFGCAFFIIFFKQLEKFYIVSIDKINLSWKSIPVAFLQKEGFEIPLTYPGIIDFIGYIDQMI

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE017332
EMBL· GenBank· DDBJ
AAV27381.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help