Q5ZU17 · LYPGN_LEGPH

Function

function

Specifically hydrolyzes the vinyl ether bond of lysoplasmenylcholine (pLPC) and lysoplasmenylethanolamine (pLPE) to release a fatty aldehyde and glycerophospho-choline or glycerophospho-ethanolamine (PubMed:25445671).
Has no activity on diradyl plasmalogen, 1-alkenyl-glycerol, and monoacylglycerophospho-ethanolamine or monoacylglycerophospho-choline (PubMed:25445671).
May serve to protect the bacterium from lysis by lysoplasmalogen derived from plasmalogens of the host (PubMed:25445671).

Catalytic activity

Activity regulation

Competitively inhibited by lysophosphatidic acid.

Kinetics

KM SUBSTRATE pH TEMPERATURE[C] NOTES EVIDENCE
45 μMlysoplasmenylcholine
45 μMlysoplasmenylethanolamine
Vmax pH TEMPERATURE[C] NOTES EVIDENCE
12 μmol/min/mgwith lysoplasmenylcholine as substrate
11 μmol/min/mgwith lysoplasmenylethanolamine as substrate

pH Dependence

Optimum pH is 6.5-7.0.

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Functionhydrolase activity
Biological Processlipid metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Lysoplasmalogenase
  • EC number
  • Alternative names
    • LpYhhN

Gene names

    • Ordered locus names
      lpg1991

Organism names

Accessions

  • Primary accession
    Q5ZU17

Proteomes

Subcellular Location

Cell inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane9-29Helical
Transmembrane32-52Helical
Transmembrane58-78Helical
Transmembrane84-104Helical
Transmembrane109-129Helical
Transmembrane131-151Helical
Transmembrane163-183Helical
Transmembrane189-209Helical

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004562191-216Lysoplasmalogenase

Proteomic databases

Interaction

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the TMEM86 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    216
  • Mass (Da)
    24,536
  • Last updated
    2004-11-23 v1
  • Checksum
    9E737F88BAC2A4AF
MTYSFSKPVSWVFLFTAVIYLVSLSFIQYPATTVLKPIPIVCLIVGVFRTSLSSSAKILLILALVFSLAGDVVLTLPFSLQLELGIACFLLAHCFYITLFLKSFEFNRLHLFYYLPIFLFMGFAAFTMIPYLGNLLIPVMIYFCVLMLMVFSAFQVKKETLTISSGALFFLISDLTLALNLFIYTQADVRIFVMFTYYVAQFLLTFGLVRLYEKGG

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE017354
EMBL· GenBank· DDBJ
AAU28060.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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