Q5ZM65 · PTSS1_CHICK
- ProteinPhosphatidylserine synthase 1
- GenePTDSS1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids473 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine (By similarity).
Catalyzes mainly the conversion of phosphatidylcholine but also converts, in vitro and to a lesser extent, phosphatidylethanolamine (By similarity).
Catalyzes mainly the conversion of phosphatidylcholine but also converts, in vitro and to a lesser extent, phosphatidylethanolamine (By similarity).
Catalytic activity
- a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + ethanolamineThis reaction proceeds in the forward direction.
- a 1,2-diacyl-sn-glycero-3-phosphocholine + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + cholineThis reaction proceeds in the forward direction.
Pathway
Phospholipid metabolism; phosphatidylserine biosynthesis.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Molecular Function | L-serine-phosphatidylcholine phosphatidyltransferase activity | |
Molecular Function | L-serine-phosphatidylethanolamine phosphatidyltransferase activity | |
Biological Process | phosphatidylserine biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhosphatidylserine synthase 1
- EC number
- Short namesPSS-1; PtdSer synthase 1
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Galloanserae > Galliformes > Phasianidae > Phasianinae > Gallus
Accessions
- Primary accessionQ5ZM65
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Note: Highly enriched in the mitochondria-associated membrane (MAM).
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-35 | Cytoplasmic | ||||
Sequence: MAACVGSRTLSKDDVNYRLHFRMINEQQVEDITLE | ||||||
Transmembrane | 36-56 | Helical | ||||
Sequence: FFYRPHTITLLSFTILSLMAF | ||||||
Topological domain | 57-72 | Lumenal | ||||
Sequence: AFTRDDSVPEENIWRG | ||||||
Transmembrane | 73-93 | Helical | ||||
Sequence: ILSVIFFFLIISVLAFPNGPF | ||||||
Topological domain | 94-102 | Cytoplasmic | ||||
Sequence: TRPHPAIWR | ||||||
Transmembrane | 103-123 | Helical | ||||
Sequence: MVFGLSVLYFLFLVFVLFLNF | ||||||
Topological domain | 124-186 | Lumenal | ||||
Sequence: EQVKAVMYWLDPNLRYATREADIMEYAVNCHVITWERILSHFDIFAFGHFWGWAMKALLIRSY | ||||||
Transmembrane | 187-207 | Helical | ||||
Sequence: GLCWTISITWELTELFFMHLL | ||||||
Topological domain | 208-216 | Cytoplasmic | ||||
Sequence: PNFAECWWD | ||||||
Transmembrane | 217-237 | Helical | ||||
Sequence: QVILDILLCNGGGIWLGMVVC | ||||||
Topological domain | 238-286 | Lumenal | ||||
Sequence: RFLEMRTYHWASFKDIHTTTGKIKRAVLQFTPASWTYVRWFDPKSSFQR | ||||||
Transmembrane | 287-307 | Helical | ||||
Sequence: VAGIYLFMIIWQLTELNTFFL | ||||||
Topological domain | 308-319 | Cytoplasmic | ||||
Sequence: KHIFVFQASHPL | ||||||
Transmembrane | 320-342 | Helical | ||||
Sequence: SWGRILFIGIITAPTVRQYYAYL | ||||||
Topological domain | 343-355 | Lumenal | ||||
Sequence: TDTQCKRVGTQCW | ||||||
Transmembrane | 356-376 | Helical | ||||
Sequence: VFGVIAFLEAIVCIKFGQDLF | ||||||
Topological domain | 377-380 | Cytoplasmic | ||||
Sequence: SKTQ | ||||||
Transmembrane | 381-401 | Helical | ||||
Sequence: ILYVVFWLLCVAFTTFLCLYG | ||||||
Topological domain | 402-473 | Lumenal | ||||
Sequence: MVWYAEYYGHREKTLSESEDSPYSPDASWLHSKFSKGADNSPPKHPVNSESHSSRRRNRHSRSKVTNGIGKK |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000416031 | 1-473 | Phosphatidylserine synthase 1 | |||
Sequence: MAACVGSRTLSKDDVNYRLHFRMINEQQVEDITLEFFYRPHTITLLSFTILSLMAFAFTRDDSVPEENIWRGILSVIFFFLIISVLAFPNGPFTRPHPAIWRMVFGLSVLYFLFLVFVLFLNFEQVKAVMYWLDPNLRYATREADIMEYAVNCHVITWERILSHFDIFAFGHFWGWAMKALLIRSYGLCWTISITWELTELFFMHLLPNFAECWWDQVILDILLCNGGGIWLGMVVCRFLEMRTYHWASFKDIHTTTGKIKRAVLQFTPASWTYVRWFDPKSSFQRVAGIYLFMIIWQLTELNTFFLKHIFVFQASHPLSWGRILFIGIITAPTVRQYYAYLTDTQCKRVGTQCWVFGVIAFLEAIVCIKFGQDLFSKTQILYVVFWLLCVAFTTFLCLYGMVWYAEYYGHREKTLSESEDSPYSPDASWLHSKFSKGADNSPPKHPVNSESHSSRRRNRHSRSKVTNGIGKK |
Proteomic databases
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 420-473 | Disordered | ||||
Sequence: EDSPYSPDASWLHSKFSKGADNSPPKHPVNSESHSSRRRNRHSRSKVTNGIGKK | ||||||
Compositional bias | 456-473 | Basic residues | ||||
Sequence: RRRNRHSRSKVTNGIGKK |
Sequence similarities
Belongs to the phosphatidyl serine synthase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length473
- Mass (Da)55,511
- Last updated2012-03-21 v2
- Checksum89D57ED2B2F40029
Features
Showing features for sequence conflict, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 184 | in Ref. 1; CAG31178 | ||||
Sequence: R → H | ||||||
Compositional bias | 456-473 | Basic residues | ||||
Sequence: RRRNRHSRSKVTNGIGKK |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AJ719519 EMBL· GenBank· DDBJ | CAG31178.1 EMBL· GenBank· DDBJ | mRNA | ||
AADN02024909 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |