Q5ZM65 · PTSS1_CHICK

  • Protein
    Phosphatidylserine synthase 1
  • Gene
    PTDSS1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    3/5

Function

function

Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine (By similarity).
Catalyzes mainly the conversion of phosphatidylcholine but also converts, in vitro and to a lesser extent, phosphatidylethanolamine (By similarity).

Catalytic activity

Pathway

Phospholipid metabolism; phosphatidylserine biosynthesis.

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Molecular FunctionL-serine-phosphatidylcholine phosphatidyltransferase activity
Molecular FunctionL-serine-phosphatidylethanolamine phosphatidyltransferase activity
Biological Processphosphatidylserine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphatidylserine synthase 1
  • EC number
  • Short names
    PSS-1; PtdSer synthase 1
  • Alternative names
    • Serine-exchange enzyme I

Gene names

    • Name
      PTDSS1
    • ORF names
      RCJMB04_2p18

Organism names

  • Taxonomic identifier
  • Strains
    • CB
    • Red jungle fowl
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Galloanserae > Galliformes > Phasianidae > Phasianinae > Gallus

Accessions

  • Primary accession
    Q5ZM65
  • Secondary accessions
    • F1P3L7

Proteomes

Organism-specific databases

Subcellular Location

Endoplasmic reticulum membrane
; Multi-pass membrane protein
Note: Highly enriched in the mitochondria-associated membrane (MAM).

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-35Cytoplasmic
Transmembrane36-56Helical
Topological domain57-72Lumenal
Transmembrane73-93Helical
Topological domain94-102Cytoplasmic
Transmembrane103-123Helical
Topological domain124-186Lumenal
Transmembrane187-207Helical
Topological domain208-216Cytoplasmic
Transmembrane217-237Helical
Topological domain238-286Lumenal
Transmembrane287-307Helical
Topological domain308-319Cytoplasmic
Transmembrane320-342Helical
Topological domain343-355Lumenal
Transmembrane356-376Helical
Topological domain377-380Cytoplasmic
Transmembrane381-401Helical
Topological domain402-473Lumenal

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004160311-473Phosphatidylserine synthase 1

Proteomic databases

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region420-473Disordered
Compositional bias456-473Basic residues

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    473
  • Mass (Da)
    55,511
  • Last updated
    2012-03-21 v2
  • Checksum
    89D57ED2B2F40029
MAACVGSRTLSKDDVNYRLHFRMINEQQVEDITLEFFYRPHTITLLSFTILSLMAFAFTRDDSVPEENIWRGILSVIFFFLIISVLAFPNGPFTRPHPAIWRMVFGLSVLYFLFLVFVLFLNFEQVKAVMYWLDPNLRYATREADIMEYAVNCHVITWERILSHFDIFAFGHFWGWAMKALLIRSYGLCWTISITWELTELFFMHLLPNFAECWWDQVILDILLCNGGGIWLGMVVCRFLEMRTYHWASFKDIHTTTGKIKRAVLQFTPASWTYVRWFDPKSSFQRVAGIYLFMIIWQLTELNTFFLKHIFVFQASHPLSWGRILFIGIITAPTVRQYYAYLTDTQCKRVGTQCWVFGVIAFLEAIVCIKFGQDLFSKTQILYVVFWLLCVAFTTFLCLYGMVWYAEYYGHREKTLSESEDSPYSPDASWLHSKFSKGADNSPPKHPVNSESHSSRRRNRHSRSKVTNGIGKK

Features

Showing features for sequence conflict, compositional bias.

TypeIDPosition(s)Description
Sequence conflict184in Ref. 1; CAG31178
Compositional bias456-473Basic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AJ719519
EMBL· GenBank· DDBJ
CAG31178.1
EMBL· GenBank· DDBJ
mRNA
AADN02024909
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp