Q5ZKL9 · PARI_CHICK

  • Protein
    PCNA-interacting partner
  • Gene
    PARPBP
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    3/5

Function

function

Required to suppress inappropriate homologous recombination, thereby playing a central role DNA repair and in the maintenance of genomic stability.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentchromatin
Cellular Componentcytoplasm
Cellular Componentnucleus
Molecular FunctionDNA binding
Biological ProcessDNA repair
Biological Processnegative regulation of double-strand break repair via homologous recombination

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    PCNA-interacting partner
  • Short names
    PARI
  • Alternative names
    • PARP-1 binding protein
    • PARP1-binding protein (PARPBP)

Gene names

    • Name
      PARPBP
    • Synonyms
      PARI
    • ORF names
      RCJMB04_10b14

Organism names

  • Taxonomic identifier
  • Strains
    • CB
    • Red jungle fowl
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Galloanserae > Galliformes > Phasianidae > Phasianinae > Gallus

Accessions

  • Primary accession
    Q5ZKL9
  • Secondary accessions
    • F1NVQ1

Proteomes

Organism-specific databases

Subcellular Location

Cytoplasm
Nucleus
Note: Localizes to chromatin.

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002802721-580PCNA-interacting partner

Proteomic databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region525-565Disordered
Compositional bias540-556Basic and acidic residues

Sequence similarities

Belongs to the PARI family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    580
  • Mass (Da)
    65,151
  • Last updated
    2012-02-22 v3
  • Checksum
    0D2496740CEA7529
MISFQQKILNLIKCFRRQWPLFSNSERTTVCGADRMLTALQLSMAEVNKQHHGDFAVSPSDVMETWKYLLHDKLGLSYENMEEPENYAAFKEAYHTFLASSNMLDIIDIYQKCCALALLSEDERIAPIQLLEFISGAMNVSESNGSVLPSTPVNRQDQSSVKVMLFAKNCFYSYLSLLVNSKDDLALACILNVPDRGLGREAFTKLKHASRERKMSIFLMATSFIRTVEHGGKGCAASLFDPLRVHVKELSNFINFIDKLGEIVGEIPDPRVAGGQILSTVKMHLMKGQSNGDPFYQAVEKVVQDLDLKIKNIIDSQHEVLTASTTGVSPTRPKLHSINHGTAYCGRDTIKVLLVLLDEEAVSAPTQNKAELLYDDVNLNMFGITSVLTLFRSPAQSKESSPKPSRQRIQKPVNEKIIKMKRSSIKSQFACTYKNELSKIRSQHFLSSSQVPACMHPAPKQHLQGKYFTEGMNSCLDIPVLGTISENVHQNRNYREMGKLSCQPRNKNSKNEQMDLNNDNVIHDEESETSLPKNAKKLKTSNNPQKELDSKIGGKRKNNRTASKNKLIVGQAKLTQFFKL

Sequence caution

The sequence CAG31724.1 differs from that shown. Reason: Erroneous termination Extended C-terminus.

Features

Showing features for sequence conflict, compositional bias.

TypeIDPosition(s)Description
Sequence conflict117in Ref. 1; CAG31724
Sequence conflict189in Ref. 1; CAG31724
Sequence conflict247in Ref. 1; CAG31724
Sequence conflict442in Ref. 1; CAG31724
Sequence conflict464in Ref. 1; CAG31724
Compositional bias540-556Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AJ720065
EMBL· GenBank· DDBJ
CAG31724.1
EMBL· GenBank· DDBJ
mRNA Sequence problems.
AADN02006329
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AADN02006330
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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