Q5ZKF9 · Q5ZKF9_CHICK
- ProteinLow-density lipoprotein receptor-related protein
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1616 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | Wnt receptor activity | |
Molecular Function | Wnt-protein binding | |
Biological Process | canonical Wnt signaling pathway | |
Biological Process | endocytosis |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameLow-density lipoprotein receptor-related protein
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Galloanserae > Galliformes > Phasianidae > Phasianinae > Gallus
Accessions
- Primary accessionQ5ZKF9
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Single-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 1387-1407 | Helical | ||||
Sequence: AIGPVIGIILSLFVMGGMYFV |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-22 | |||||
Sequence: MEAAPPLPLLLLLRLLAASVLR | ||||||
Chain | PRO_5014212513 | 23-1616 | Low-density lipoprotein receptor-related protein | |||
Sequence: CEPGSAGASPFLLFANRRDVRLVDAGGTKLESTVVVSGLEDAAAVDFQYSQGIVFWTDVSEEAIKQTYINQTGNVVQNVIISGLVSPDGLACDWIGKKLYWTDSETNRIEVANLNGTSRKVLFWQDLDQPRAIALDPAHGYMYWTDWGETPRIERAGMDSSTRKIIVDSDIYWPNGLTIDLDEQKLYWADAKLSFIHRANLDGSFRQKVVEGSLTHPFALTLSGDTLYWTDWQTRSIHACNKRTGEKRREILSALYSPMDIQVLSPDRQPYFHTPCEENNGGCSHLCLLSPRDPFYSCACPTGVQLEDDGRTCKSGAEEVLLLARRTDLRRISLDMPDFTDIILQIDNIRHAIAIDYDPVEGYIYWTDDDVRAIRRAYLDGSGAQTLVTTEINHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTSRKILISENLDEPRAIVLNPVMGYMYWTDWGESPKIECAYLDGSERRVLVNTSLGWPNGLALDLEEDKLYWGDAKTDKIEVINVDGTMRKTLLEDKLPHIFGFTLLGDYIYWTDWQRRSIERVHKIRASRDIIIDQLPDLMGLKATSVTKVFGTNPCAENNGGCSHLCFFTPQETRCACPIGLELLSDMKTCIIPEAFLVFTSRAAIHRISLETNNNDVAIPLTGVKEASALDFDVSDNRIYWTDVSLKTISRAFMNGSSVEHVIEFGLDYPEGMAVDWMGKNLYWADTGTNRIEVARLDGQYRQVLVWKDLDNPRSLALDPTKGYMYWTEWGGKPRIVRAYMDGTNSITLVDKVGRANDLTIDYADQRLYWTDLDTSMIESSNMLGQEREIIADDLPHPFGLTQYSDYIYWTDWNLHSIERADKTSGKNRTLIQGHLDFVMDILVFHSSRQDGLNDCVQNNGHCGHLCLAIPNGFRCGCAAHYTLDPNSRNCSSPTSFLLFSQKSAISRMIPDDQQSPDIILPMHGLRNVKAIDYDPLDKLIYWVDGRQNIIKRAKDDGTQPFTVMSSPNQSQNPEKQPHDLSIDIYSHTLYWTCEATNSVNVHRLNGESIGMVLRGDHDKPRAIVVNAERGYMYFTNMQERAPKIERAALDGTEREVLFTTGLIRPVALVIDNKLGKLFWVDADLKRIESCDLSGANRVTLEDSNILQPMGLTVLGNHLYWIDRQQQMIERVEKTNGYKRTRIQGRIAHLTGIHAVEELDMEEFSAHPCSRDNGGCSHICIAKGDGTPRCSCPEHLVLLQNLLTCGEPPTCSPDQFTCATGEIDCIPMAWRCDGFPECDDQSDEDSCPICSASQFQCEKGQCIDAHLRCNGEIDCQDKSDEVDCDTICLLNQFRCASGQCILLKQQCDSFPDCIDGSDELMCEKSKPSSDEPQPHSSAIGPVIGIILSLFVMGGMYFVCQRVVCQRYAGPNSPFPHEYVSGTPHVPLNFIAPGSSQHGTFTGISCGKSMISSMSLMGGSSGAPLYDRNHVTGASSSSSSSTKATFYPQILNPPPSPATDRSLYNAEMFYSSNIPSTTRSYRPYLIRGTAPPTTPCSTDVCDSDYTTSRWKANKYYIDLNSDSDPYPPPPTPRSQYMSAEESCPPSPATERSYFHLYPPPPSPCTDSS | ||||||
Disulfide bond | 1281↔1296 | |||||
Sequence: CDGFPECDDQSDEDSC | ||||||
Disulfide bond | 1299↔1311 | |||||
Sequence: CSASQFQCEKGQC | ||||||
Disulfide bond | 1306↔1324 | |||||
Sequence: CEKGQCIDAHLRCNGEIDC | ||||||
Disulfide bond | 1318↔1333 | |||||
Sequence: CNGEIDCQDKSDEVDC | ||||||
Disulfide bond | 1337↔1349 | |||||
Sequence: CLLNQFRCASGQC | ||||||
Disulfide bond | 1344↔1362 | |||||
Sequence: CASGQCILLKQQCDSFPDC | ||||||
Disulfide bond | 1356↔1371 | |||||
Sequence: CDSFPDCIDGSDELMC |
Keywords
- PTM
Interaction
Subunit
Homodimer; disulfide-linked. Forms phosphorylated oligomer aggregates on Wnt-signaling.
Structure
Family & Domains
Features
Showing features for repeat, domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Repeat | 119-161 | LDL-receptor class B | ||||
Sequence: KKLYWTDSETNRIEVANLNGTSRKVLFWQDLDQPRAIALDPAH | ||||||
Repeat | 162-205 | LDL-receptor class B | ||||
Sequence: GYMYWTDWGETPRIERAGMDSSTRKIIVDSDIYWPNGLTIDLDE | ||||||
Repeat | 206-248 | LDL-receptor class B | ||||
Sequence: QKLYWADAKLSFIHRANLDGSFRQKVVEGSLTHPFALTLSGDT | ||||||
Domain | 297-336 | EGF-like | ||||
Sequence: PCEENNGGCSHLCLLSPRDPFYSCACPTGVQLEDDGRTCK | ||||||
Repeat | 384-426 | LDL-receptor class B | ||||
Sequence: GYIYWTDDDVRAIRRAYLDGSGAQTLVTTEINHPDGIAVDWVA | ||||||
Repeat | 427-469 | LDL-receptor class B | ||||
Sequence: RNLYWTDTGTDRIEVTRLNGTSRKILISENLDEPRAIVLNPVM | ||||||
Repeat | 470-513 | LDL-receptor class B | ||||
Sequence: GYMYWTDWGESPKIECAYLDGSERRVLVNTSLGWPNGLALDLEE | ||||||
Repeat | 514-556 | LDL-receptor class B | ||||
Sequence: DKLYWGDAKTDKIEVINVDGTMRKTLLEDKLPHIFGFTLLGDY | ||||||
Domain | 603-640 | EGF-like | ||||
Sequence: PCAENNGGCSHLCFFTPQETRCACPIGLELLSDMKTCI | ||||||
Repeat | 686-728 | LDL-receptor class B | ||||
Sequence: NRIYWTDVSLKTISRAFMNGSSVEHVIEFGLDYPEGMAVDWMG | ||||||
Repeat | 729-771 | LDL-receptor class B | ||||
Sequence: KNLYWADTGTNRIEVARLDGQYRQVLVWKDLDNPRSLALDPTK | ||||||
Repeat | 772-814 | LDL-receptor class B | ||||
Sequence: GYMYWTEWGGKPRIVRAYMDGTNSITLVDKVGRANDLTIDYAD | ||||||
Repeat | 815-856 | LDL-receptor class B | ||||
Sequence: QRLYWTDLDTSMIESSNMLGQEREIIADDLPHPFGLTQYSDY | ||||||
Domain | 904-941 | EGF-like | ||||
Sequence: DCVQNNGHCGHLCLAIPNGFRCGCAAHYTLDPNSRNCS | ||||||
Region | 1005-1027 | Disordered | ||||
Sequence: DDGTQPFTVMSSPNQSQNPEKQP | ||||||
Compositional bias | 1009-1027 | Polar residues | ||||
Sequence: QPFTVMSSPNQSQNPEKQP | ||||||
Repeat | 1080-1124 | LDL-receptor class B | ||||
Sequence: GYMYFTNMQERAPKIERAALDGTEREVLFTTGLIRPVALVIDNKL | ||||||
Repeat | 1125-1167 | LDL-receptor class B | ||||
Sequence: GKLFWVDADLKRIESCDLSGANRVTLEDSNILQPMGLTVLGNH | ||||||
Domain | 1217-1255 | EGF-like | ||||
Sequence: PCSRDNGGCSHICIAKGDGTPRCSCPEHLVLLQNLLTCG | ||||||
Compositional bias | 1479-1497 | Polar residues | ||||
Sequence: VTGASSSSSSSTKATFYPQ | ||||||
Region | 1479-1500 | Disordered | ||||
Sequence: VTGASSSSSSSTKATFYPQILN | ||||||
Region | 1567-1616 | Disordered | ||||
Sequence: LNSDSDPYPPPPTPRSQYMSAEESCPPSPATERSYFHLYPPPPSPCTDSS | ||||||
Compositional bias | 1602-1616 | Pro residues | ||||
Sequence: FHLYPPPPSPCTDSS |
Sequence similarities
Belongs to the LDLR family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,616
- Mass (Da)180,883
- Last updated2004-11-23 v1
- Checksum83A9C75DBF7EEA72
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1009-1027 | Polar residues | ||||
Sequence: QPFTVMSSPNQSQNPEKQP | ||||||
Compositional bias | 1479-1497 | Polar residues | ||||
Sequence: VTGASSSSSSSTKATFYPQ | ||||||
Compositional bias | 1602-1616 | Pro residues | ||||
Sequence: FHLYPPPPSPCTDSS |
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AJ720125 EMBL· GenBank· DDBJ | CAG31784.1 EMBL· GenBank· DDBJ | mRNA |