our results demonstrate the importance of AMPK-mediated phosphorylation of beta1Pix at Ser(71) which promotes 14-3-3 interactions with beta1Pix and Nedd4-2 to form a tripartite ENaC inhibitory complex in the mechanism of ENaC regulation by AMPK
S340E mutation enhances Nox1 activation (Kaito et al. 2014) the present study suggests that betaPix can also play an inhibitory role in O2(-) production depending on the sites of phosphorylation.
Induced association of beta-PIX with GIT1 is essential for the stimulation of intestinal epithelial restitution by activating Rac1 and this signaling pathway is tightly regulated by cellular polyamines.
Data suggest that Scribble PDZ-domain-1 and PDZ-domain-3 are major domains that interact with beta-PIX and exhibit distinct binding hierarchy in interactions between individual Scribble PDZ domains and beta-PIX. (Scribble = scribbled planar cell polarity protein; beta-PIX = Rho guanine nucleotide exchange factor 7)
Traction forces generated by beta-PIX knockdown cells are increased relative to those in control cells a result consistent with an unexpected enhancement in the migration of single beta-PIX knockdown cells and monolayers of such cells. Authors propose that targeting beta-PIX might be a means of promoting epithelialization of wounds in vivo.
we discuss recent findings in key physiological systems that exemplify current understanding of the function of this important regulatory complex. Further we draw attention to gaps in crucial information that remain to be filled to allow a better understanding of the many roles of the GIT-PIX complex in health and disease
Data show association of G protein-coupled receptor kinase-interacting protein 1 (GIT1) p21-activated kinase interacting exchange factor (betaPIX) and p21 protein (Cdc42/Rac)-activated kinase 1 (PAK1) with centrosomes.
Data show the role of Rho guanine nucleotide exchange factor 7 (beta-PIX) to the regulation of high mobility of lung adenocarcinoma cell line H1299 via regulation of focal adhesions dynamics changes in actin cytoskeleton organization and cell polarity.
Conversely increased expression of betaPIX in breast cancer cell lines re-couples the Hippo kinase cassette to Yap/Taz promoting localization of Yap/Taz to the cytoplasm and inhibiting cell migration and proliferation.
GIT1/betaPIX/Rac1/PAK pathway plays a crucial role in regulating GABA(A)R synaptic stability and hence inhibitory synaptic transmission with important implications for inhibitory plasticity and information processing in the brain.
Data indicate that suppression of c-Cbl protein by rho guanine nucleotide exchange factor 7 (Cool-1) may be critical for generation of at least a subset of glioblastoma (GBM).
beta1Pix functions as a transcriptional regulator of beta-catenin signaling through direct interaction with beta-catenin an action that may be functionally relevant to colon cancer biology.
It has identified and characterized a novel interaction between CaM and beta-p21-activated kinase interacting exchange factor (beta-PIX) a putative guanine exchange factor implicated in cell signaling.
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