Q5Z8Q9 · PRP2A_ORYSJ
- ProteinPoly [ADP-ribose] polymerase 2-A
- GenePARP2-A
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids660 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks (By similarity).
Catalytic activity
- L-aspartyl-[protein] + NAD+ = 4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + nicotinamide
- L-glutamyl-[protein] + NAD+ = 5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + nicotinamide
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | nucleolus | |
Molecular Function | DNA binding | |
Molecular Function | NAD+ ADP-ribosyltransferase activity | |
Molecular Function | NAD+-protein ADP-ribosyltransferase activity | |
Molecular Function | nucleotidyltransferase activity | |
Biological Process | double-strand break repair |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePoly [ADP-ribose] polymerase 2-A
- EC number
- Short namesPARP-2-A
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > Liliopsida > Poales > Poaceae > BOP clade > Oryzoideae > Oryzeae > Oryzinae > Oryza > Oryza sativa
Accessions
- Primary accessionQ5Z8Q9
- Secondary accessions
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000260503 | 1-660 | Poly [ADP-ribose] polymerase 2-A | |||
Sequence: MSARLRVEELRAELQRRGLDASGNKPVLVRRLDAAIRKEEEEEAAVSAAAKEEADAGGVVDGEGNGEDKRKRKRRGDGEDVDNSESDAAKLEGMSYRELQALAKSRGLAANGSKKEVIERLLCAPSDTDGGVQDKKKIAKGFADGDDRVEECRKEKIVTATRKGAAVLDQHIPDHIKMTYHVLQVWFLLKGDEIYDATMNQTNVGDNNNKFYIIQALESDAGGSFMVYNRWGRVGARGQDKLHGPFSSREQAIYEFEGKFHGKTNNHWSDRKSFECYARKYTWLEMDYGEADRETNKKVSPSTDQIKETKLETRIASFISLICNISMMKQQMVEIGYNSDKLPLGKLSKSTIFKGYDVLKRISNVISRADRRQLEQLTGEFYTVIPHDFGFKKMREFIIDTPQKLKAKLEMVEALGEIEIATKLLEDDSTDQDDPLYARYKQLSCDFTPLEVGSEEYSMIKTYLANTHGKTHTSYTVDVVQIFKVSRHGEMERFQKFATAGNRMLLWHGSRLTNWAGILSQGLRIAPPEAPVTGYMFGKGVYFADMFSKSANYCYASEACRSGVLLLCEVALGEMNELLNADYDANNLPKGKLSTKGVGQTEPNTAESKITDDGVVVPLGKPKAEPSKRGSLLYNEFIVYNVDQIRMRYVLHVSFNFKKR |
Keywords
- PTM
Proteomic databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias, motif.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 2-36 | SAP 1 | ||||
Sequence: SARLRVEELRAELQRRGLDASGNKPVLVRRLDAAI | ||||||
Region | 40-92 | Disordered | ||||
Sequence: EEEEAAVSAAAKEEADAGGVVDGEGNGEDKRKRKRRGDGEDVDNSESDAAKLE | ||||||
Compositional bias | 56-87 | Basic and acidic residues | ||||
Sequence: AGGVVDGEGNGEDKRKRKRRGDGEDVDNSESD | ||||||
Motif | 69-75 | Nuclear localization signal | ||||
Sequence: KRKRKRR | ||||||
Domain | 91-125 | SAP 2 | ||||
Sequence: LEGMSYRELQALAKSRGLAANGSKKEVIERLLCAP | ||||||
Domain | 179-281 | WGR | ||||
Sequence: TYHVLQVWFLLKGDEIYDATMNQTNVGDNNNKFYIIQALESDAGGSFMVYNRWGRVGARGQDKLHGPFSSREQAIYEFEGKFHGKTNNHWSDRKSFECYARKY | ||||||
Domain | 308-426 | PARP alpha-helical | ||||
Sequence: ETKLETRIASFISLICNISMMKQQMVEIGYNSDKLPLGKLSKSTIFKGYDVLKRISNVISRADRRQLEQLTGEFYTVIPHDFGFKKMREFIIDTPQKLKAKLEMVEALGEIEIATKLLE | ||||||
Domain | 434-660 | PARP catalytic | ||||
Sequence: DPLYARYKQLSCDFTPLEVGSEEYSMIKTYLANTHGKTHTSYTVDVVQIFKVSRHGEMERFQKFATAGNRMLLWHGSRLTNWAGILSQGLRIAPPEAPVTGYMFGKGVYFADMFSKSANYCYASEACRSGVLLLCEVALGEMNELLNADYDANNLPKGKLSTKGVGQTEPNTAESKITDDGVVVPLGKPKAEPSKRGSLLYNEFIVYNVDQIRMRYVLHVSFNFKKR |
Sequence similarities
Belongs to the ARTD/PARP family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length660
- Mass (Da)74,297
- Last updated2006-11-28 v2
- Checksum94FA8F38B72470A9
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A0N7KCX5 | A0A0N7KCX5_ORYSJ | Os01g0351200 | 650 |
Sequence caution
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 56-87 | Basic and acidic residues | ||||
Sequence: AGGVVDGEGNGEDKRKRKRRGDGEDVDNSESD |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AP003258 EMBL· GenBank· DDBJ | BAD52929.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
AP003764 EMBL· GenBank· DDBJ | BAD53855.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
AP008207 EMBL· GenBank· DDBJ | BAF04898.2 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
AP014957 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |