Q5Z880 · HRD1_ORYSJ

Function

function

Probable component of the HRD1 ubiquitin ligase complex that mediates the rapid degradation of misfolded endoplasmic reticulum (ER) proteins, a process called ER-associated degradation (ERAD).

Catalytic activity

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.
    EC:2.3.2.27 (UniProtKB | ENZYME | Rhea)

Pathway

Protein modification; protein ubiquitination.

GO annotations

all annotationsall molecular functionnucleotide bindingmolecular_functionnucleic acid bindingdna bindingchromatin bindingdna-binding transcription factor activityrna bindingcytoskeletal motor activitycatalytic activitynuclease activitysignaling receptor bindingstructural molecule activitytransporter activitybindingprotein bindingtranslation factor activity, rna bindinglipid bindingkinase activitytransferase activityhydrolase activityoxygen bindingenzyme regulator activitycarbohydrate bindingsignaling receptor activitytranslation regulator activitytranscription regulator activityother molecular functionall biological processcarbohydrate metabolic processgeneration of precursor metabolites and energynucleobase-containing compound metabolic processdna metabolic processtranslationlipid metabolic processtransportresponse to stresscell cyclecell communicationsignal transductioncell-cell signalingmulticellular organism developmentcircadian rhythmbiological_processmetabolic processcatabolic processbiosynthetic processresponse to light stimulusresponse to external stimulustropismresponse to biotic stimulusresponse to abiotic stimulusresponse to endogenous stimulusembryo developmentpost-embryonic developmentfruit ripeningabscissionpollinationflower developmentcellular processprogrammed cell deathphotosynthesiscellular component organizationcell growthprotein metabolic processcellular homeostasissecondary metabolic processreproductive processcell differentiationprotein modification processgrowthepigenetic regulation of gene expressionresponse to chemicalanatomical structure developmentregulation of molecular functionother biological processall cellular componentcellular_componentextracellular regioncell wallintracellular anatomical structurenucleusnuclear envelopenucleoplasmnucleoluscytoplasmmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuscytosolribosomecytoskeletonplasma membranechloroplastplastidthylakoidmembraneexternal encapsulating structureother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentendomembrane system
Cellular Componentendoplasmic reticulum membrane
Molecular Functionmetal ion binding
Molecular Functionubiquitin protein ligase activity
Biological ProcessERAD pathway
Biological Processproteasome-mediated ubiquitin-dependent protein catabolic process
Biological Processprotein ubiquitination

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ERAD-associated E3 ubiquitin-protein ligase HRD1
  • EC number
  • Alternative names
    • RING-type E3 ubiquitin transferase HRD1

Gene names

    • Name
      HRD1
    • ORF names
      OJ1217_C01.4
      , P0501G08.42
    • Ordered locus names
      Os06g0301000
      , LOC_Os06g19680

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Nipponbare
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > Liliopsida > Poales > Poaceae > BOP clade > Oryzoideae > Oryzeae > Oryzinae > Oryza > Oryza sativa

Accessions

  • Primary accession
    Q5Z880
  • Secondary accessions
    • A0A0P0WVN5

Proteomes

Genome annotation databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

Type
IDPosition(s)Description
Topological domain1-3Cytoplasmic
Transmembrane4-24Helical; Name=1
Topological domain25-40Lumenal
Transmembrane41-61Helical; Name=2
Topological domain62-98Cytoplasmic
Transmembrane99-119Helical; Name=3
Topological domain120-135Lumenal
Transmembrane136-156Helical; Name=4
Topological domain157-170Cytoplasmic
Transmembrane171-191Helical; Name=5
Topological domain192-225Lumenal
Transmembrane226-246Helical; Name=6
Topological domain247-500Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for chain, modified residue (large scale data).

Type
IDPosition(s)Source
Description
ChainPRO_00004312721-500UniProtERAD-associated E3 ubiquitin-protein ligase HRD1
Modified residue (large scale data)425PTMeXchangePhosphoserine

Proteomic databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for zinc finger, region, compositional bias.

Type
IDPosition(s)Description
Zinc finger292-330RING-type; atypical
Region337-375Disordered
Compositional bias398-431Polar residues
Region398-438Disordered

Sequence similarities

Belongs to the HRD1 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    500
  • Mass (Da)
    56,262
  • Last updated
    2004-11-23 v1
  • Checksum
    1C42744325E09277
MIRLQTYAAFSLMATATAVYYAFSSREQFYPAMVYLSTSKICFVLLLNTGLVAMCVAWQLVKRLFLGTLREAEVERLNEQAWREVVEILFAVTIFRQDFSVSFLAMVAALLLVKALHWLAQKRVEYIETTPSVPMLSHARIVSFMLFLLVVDCLFLSNSLRSLIHKREASVAIFFSFEYMILATSTVSTFVKYIFYVSDMLMEGQWEKKAVYTFYLELISDLVHLSLYMLFFIAIFLNYGVPLHLIRELYETFRNFRIRIADYVRYRKITSNMNERFPDATADELNASDATCIICREEMTTAKKLLCGHLFHVHCLRSWLERQHTCPTCRAPILPPDNGRTAARPHGVHPGVQPVPGNGTPGSERAAGENISRRQAKLEAAASAASLYGRSFAYPPANNLNRYSTPPQSTSNGPQSGEASTSNQSPKGHATADPSAPTFYARGAVSSVTTTRELESSLQKAYENAIKSQIEMLQIQLQMFQHGATSSATNNENGEHTKSD

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias398-431Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AP003524
EMBL· GenBank· DDBJ
BAD53494.1
EMBL· GenBank· DDBJ
Genomic DNA
AP004007
EMBL· GenBank· DDBJ
BAD53976.1
EMBL· GenBank· DDBJ
Genomic DNA
AP008212
EMBL· GenBank· DDBJ
BAF19368.1
EMBL· GenBank· DDBJ
Genomic DNA
AP014962
EMBL· GenBank· DDBJ
BAS97382.1
EMBL· GenBank· DDBJ
Genomic DNA
AK073960
EMBL· GenBank· DDBJ
BAG93732.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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